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June 17, 2013

Key Protein is Linked to Circadian Clocks; Helps Regulate Metabolism

SAN FRANCISCO, CA—Inside each of us is our own internal timing device. It drives everything from sleep cycles to metabolism, but the inner-workings of this so-called “circadian clock” are complex, and the molecular processes behind it have long eluded scientists.

Akassoglou Lab Metabolism

June 8, 2013

Gladstone Scientists Map Process by which Brain Cells Form Long-Term Memories

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have deciphered how a protein called Arc regulates the activity of neurons—providing much-needed clues into the brain’s ability to form long-lasting memories.

Finkbeiner Lab

May 14, 2013

Gladstone’s Lennart Mucke Wins MetLife Foundation Award

SAN FRANCISCO, CA—Lennart Mucke, MD, who directs neurological research at the Gladstone Institutes, today received the MetLife Foundation’s 2013 Award for Medical Research in Alzheimer’s Disease at a scientific briefing and awards ceremony in New York.

Alzheimer’s Disease Mucke Lab

Article March 24, 2013

Gladstone Investigator Shinya Yamanaka to Receive “Commitment to a Cure” Award from the ALS Community

SAN FRANCISCO, CA—Shinya Yamanaka, MD, PhD, a senior investigator at the Gladstone Institutes, next month will receive the Essey Award for his “Commitment to a Cure” from The ALS Association Golden West Chapter. This annual award represents the exceptional determination, spirit and dedication to the fight against amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease.

ALS Yamanaka Lab Stem Cells/iPSCs

March 23, 2013

Gladstone Scientists Discover that DNA Damage Occurs as Part of Normal Brain Activity

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have discovered that a certain type of DNA damage long thought to be particularly detrimental to brain cells can actually be part of a regular, non-harmful process.

Alzheimer’s Disease Mucke Lab

February 19, 2013

Gladstone Scientist Named Inaugural Winner of Breakthrough Prize in Life Sciences

SAN FRANCISCO, CA—Gladstone Institutes’ Senior Investigator Shinya Yamanaka, MD, PhD, is one of 11 medical researchers to win a new, high-profile $3 million award from a group of high-tech sponsors, including the founders of Facebook and Google.

Stem Cells/iPSCs Yamanaka Lab Stem Cells/iPSCs

January 6, 2013

Unique Protein Interaction May Drive Most Common Genetic Cause of Parkinson’s Disease

San Francisco, CA—The most devastating aspect of Parkinson’s disease may not be its debilitating symptoms, which rob its victims of their ability to control their own movement. It may not be the millions around the world and their families who suffer each day from the disease’s harmful effects.

Finkbeiner Lab

December 19, 2012

Gladstone Scientists Identify Powerful Infection Strategy of Widespread and Potentially Lethal Virus

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have mapped the molecular mechanism by which a virus known as cytomegalovirus (CMV) so successfully infects its hosts.

Weinberger Lab

December 5, 2012

Gladstone Scientists Discover Novel Mechanism by Which Calorie Restriction Influences Longevity

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have identified a novel mechanism by which a type of low-carb, low-calorie diet—called a “ketogenic diet”—could delay the effects of aging.

Aging

December 4, 2012

Gladstone Scientists: “ApoE Is an Ideal Target for Halting Progression of Alzheimer’s Disease”

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes are recommending a shift in efforts to treat Alzheimer’s disease by developing drugs that target the apoE4 protein, which has long been associated with an increased risk for the disease.

Alzheimer’s Disease Huang Lab Mahley Lab

December 3, 2012

ALS Therapy Development Institute and Gladstone Institutes Collaborate to Discover Potential ALS Treatments

CAMBRIDGE, MA and SAN FRANCISCO, CA—The ALS Therapy Development Institute (ALS TDI) and the Gladstone Institutes today announced the formation of a research collaboration to speed the discovery of potential treatments for ALS through the preclinical drug development process.

ALS Finkbeiner Lab

November 26, 2012

Gladstone Scientists Identify Key Biological Mechanism in Multiple Sclerosis

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have defined for the first time a key underlying process implicated in multiple sclerosis (MS)—a disease that causes progressive and irreversible damage to nerve cells in the brain and spinal cord.

Akassoglou Lab Multiple Sclerosis

October 28, 2012

Gladstone President to Receive Prestigious Pacesetter Award

SAN FRANCISCO, CA—Gladstone President R. Sanders "Sandy" Williams, MD, will receive the ARCS Foundation’s 2012 Pacesetter Award next week for his lifelong dedication to furthering education and his extensive contributions to science and medicine.

October 27, 2012

Gladstone, Stanford Scientists Collaborate to Block Toxic Protein that Plays Key Role in Lou Gehrig’s Disease

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes and the Stanford University School of Medicine have discovered how modifying a gene halts the toxic buildup of a protein found in nerve cells. These findings point to a potential new tactic for treating a variety of neurodegenerative conditions, including amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease)—a fatal disease for which there is no cure.

ALS

October 7, 2012

Gladstone Scientists Discover Gene “Bursting” Plays Key Role in Protein Production

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have mapped the precise frequency by which genes get turned on across the human genome, providing new insight into the most fundamental of cellular processes—and revealing new clues as to what happens when this process goes awry.

Basic Science Weinberger Lab

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Congrats to Jennifer Doudna, winner of the 2020 Nobel Prize in Chemistry!