News

Gladstone in the News March 30, 2022

Obesity Can Turn a Helpful Immunotherapy into a Harmful One, Mouse Study Shows

STAT News—Alexander Marson, director of the Gladstone-UCSF Institute of Genomic Immunology, describes new research from his group showing that the immune response in a mouse model of atopic dermatitis is altered by obesity. This difference rendered first-line therapies ineffective in mice, indicating that treatments for inflammatory disorders may need to be tailored to work in individual patients, depending on their metabolic state.

Gladstone Experts Genomic Immunology Marson Lab Disease Models Metabolism

Article August 27, 2020

Cellular Energy Audit Reveals Energy Producers and Consumers

A team at Gladstone Institutes screened the human genome for genes that play a role in making or consuming cellular energy

News Release Research (Publication) Parkinson’s Disease Heart Failure Neurological Disease Nakamura Lab Disease Models Genomics Metabolism

Article January 17, 2017

Scientists Discover Drug that Increases “Good” Fat Mass and Function

Anti-cancer drug prevented less weight gain and caused mice to burn more calories thanks to higher levels of metabolism-boosting brown fat.

Ding Lab Metabolism Diabetes

Article January 11, 2016

Brain Receptor Regulates Fat Burning in Cells

Scientists at the Gladstone Institutes have discovered an unusual regulator of body weight and the metabolic syndrome: a molecular mechanism more commonly associated with brain cells.

Diabetes Neurological Disease Akassoglou Lab Basic Science Metabolism

November 22, 2015

Gene Identified that Produces the Benefits of Steroids, but Without the Detrimental Side Effects

Scientists have revealed that glucocorticoids, a class of steroid hormones that are commonly prescribed as drugs, enhance muscle endurance and alleviate muscular dystrophy through activation of the gene KLF15.

Haldar Lab Cardiovascular Disease Basic Science Metabolism

Article September 13, 2015

Loss of Cellular Energy Leads to Neuronal Dysfunction in a Model of Neurodegenerative Disease

A new study from the Gladstone Institutes shows for the first time that impairments in mitochondria—the brain’s cellular power plants—can deplete cellular energy levels and cause neuronal dysfunction in a model of neurodegenerative disease.

Parkinson’s Disease Neurological Disease Nakamura Lab Basic Science Metabolism

June 17, 2013

Key Protein is Linked to Circadian Clocks; Helps Regulate Metabolism

SAN FRANCISCO, CA—Inside each of us is our own internal timing device. It drives everything from sleep cycles to metabolism, but the inner-workings of this so-called “circadian clock” are complex, and the molecular processes behind it have long eluded scientists.

Akassoglou Lab Metabolism

March 27, 2012

Gladstone Scientists Identify Key Mechanism Involved in Type 2 Diabetes

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have discovered a key protein that regulates insulin resistance—the diminished ability of cells to respond to the action of insulin and which sets the stage for the development of the most common form of diabetes.

Akassoglou Lab Diabetes Metabolism

August 17, 2011

Gladstone Scientist Identifies Gene that Exacerbates Risk Factors for Heart Disease and Diabetes

SAN FRANCISCO, CA—A scientist at the Gladstone Institutes has discovered how a gene known as SIRT3 contributes to a suite of health problems sweeping across America, offering new insight into how to combat these potentially fatal conditions.

Diabetes Metabolism

March 14, 2009

Gladstone Scientists Reveal Key Enzyme in Fat Absorption

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes of Cardiovascular Disease (GICD) have found that a key enzyme involved in absorbing fat may also be a key to reducing it.

Metabolism