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New research shows low oxygen can help alleviate disease caused by defects in a mitochondrial quality control machinery.
News Release Research (Publication) Jain Lab Metabolism
Leveraging modern scientific tools and techniques, Jain intends to transform our understanding of the critical roles that vitamins play in health and disease.
Awards News Release Cardiovascular Disease Jain Lab Metabolism
STAT News—Alexander Marson, director of the Gladstone-UCSF Institute of Genomic Immunology, describes new research from his group showing that the immune response in a mouse model of atopic dermatitis is altered by obesity. This difference rendered first-line therapies ineffective in mice, indicating that treatments for inflammatory disorders may need to be tailored to work in individual patients, depending on their metabolic state.
Gladstone Experts Genomic Immunology Marson Lab Disease Models Metabolism
A team at Gladstone Institutes screened the human genome for genes that play a role in making or consuming cellular energy
News Release Research (Publication) Parkinson’s Disease Heart Failure Neurological Disease Nakamura Lab Disease Models Genomics Metabolism
Anti-cancer drug prevented less weight gain and caused mice to burn more calories thanks to higher levels of metabolism-boosting brown fat.
Ding Lab Metabolism Diabetes
Scientists at the Gladstone Institutes have discovered an unusual regulator of body weight and the metabolic syndrome: a molecular mechanism more commonly associated with brain cells.
Diabetes Neurological Disease Akassoglou Lab Basic Science Metabolism
Scientists have revealed that glucocorticoids, a class of steroid hormones that are commonly prescribed as drugs, enhance muscle endurance and alleviate muscular dystrophy through activation of the gene KLF15.
Haldar Lab Cardiovascular Disease Basic Science Metabolism
A new study from the Gladstone Institutes shows for the first time that impairments in mitochondria—the brain’s cellular power plants—can deplete cellular energy levels and cause neuronal dysfunction in a model of neurodegenerative disease.
Parkinson’s Disease Neurological Disease Nakamura Lab Basic Science Metabolism
SAN FRANCISCO, CA—Inside each of us is our own internal timing device. It drives everything from sleep cycles to metabolism, but the inner-workings of this so-called “circadian clock” are complex, and the molecular processes behind it have long eluded scientists.
Akassoglou Lab Metabolism
SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have discovered a key protein that regulates insulin resistance—the diminished ability of cells to respond to the action of insulin and which sets the stage for the development of the most common form of diabetes.
Akassoglou Lab Diabetes Metabolism
SAN FRANCISCO, CA—A scientist at the Gladstone Institutes has discovered how a gene known as SIRT3 contributes to a suite of health problems sweeping across America, offering new insight into how to combat these potentially fatal conditions.
Diabetes Metabolism
SAN FRANCISCO, CA—Scientists at the Gladstone Institutes of Cardiovascular Disease (GICD) have found that a key enzyme involved in absorbing fat may also be a key to reducing it.
Metabolism
