Through collaborative interactions and consultations, the Behavioral Core serves researchers at Gladstone, UC San Francisco, other nonprofit research institutions, and for-profit entities.

Together with colleagues in clinical programs, we are investigating the relation between impairments in patients with brain disorders and in rodent models simulating these conditions. These studies aim to promote the development of suitable tests and novel treatment strategies to improve cognition and other neural functions in patients suffering from devastating diseases of the nervous system.


Our Process

Initiate Project

  • Selection of tests to validate specific hypotheses based on careful review of the pertinent literature and the core database.
  • Behavioral test battery customized according to specific experimental or therapeutic interventions and mouse models.

Behavioral Testing

  • Battery of 60+ behavioral tests covering diverse behavioral domains including sensorimotor functions, emotional and social behaviors, and cognitive functions such as learning and memory.
  • State-of-the-art equipment not typically seen in individual labs.
  • Experienced personnel ensures conclusive design and reliable execution of experiments.

Data Analysis

  • Rigorous statistical analyses and expert interpretation of data.
  • Presentation-ready data package delivered on completion of project.


  • Assistance with manuscript and report preparation.

Services Provided

We offer nearly 70 different assessments covering diverse behavioral domains, including sensorimotor functions, emotional and social behaviors, and cognitive functions such as learning and memory.

View List of Tests Offered


Jeff Simms, MA
Core Director

Core Members

Elise Deng
Research Technologist I

Linsey Dinh
Research Technologist I

Lane Domke
Research Technologist I

Julia Holtzman
Research Technologist III

Iris Lo
Associate Core Director

Jeff Simms
Core Director


Our core offers nearly 70 different assessments.

Anxiety/Depression-Related Tests

  • Chronic Intermittent Stress
  • Elevated Plus Maze
  • Forced Swim Test
  • Light/Dark Box
  • Novelty-Suppressed Feeding
  • Restraint Stress
  • Social Defeat Stress
  • Sucrose Preference
  • Tail Suspension

Cognitive Tests

  • Barnes Maze
  • Conditioned Place Aversion
  • Conditioned Place Preference
  • Contextual Fear Conditioning
  • Cued Fear Conditioning
  • Five Choice Serial Reaction Time
  • Hole Board Task
  • Interactive Place Avoidance
  • Morris Water Maze
  • Novel Arm Recognition
  • Novel Object Recognition
  • Novel Place Recognition
  • Object/Context Congruence
  • Olfactory Discrimination
  • Operant/Instrumental Conditioning
  • Operant Self Administration
  • Pattern Separation
  • Paired Associates Learning
  • Passive/Active Avoidance
  • Pavlovian Conditioned Approach
  • Repeated Open Field Activity
  • Response Learning
  • Spontaneous Alternation
  • Visual Discrimination
  • Water Cross Maze

Innate Behaviors

  • Burrowing
  • Developmental Milestones
  • Marble Burying
  • Nesting
  • Self-Grooming
  • Ultrasonic Vocalization

Sensorimotor Tests

  • Balance Beam
  • Climbing Cylinder
  • Forced Exercise
  • Gait Analysis
  • Grip Strength
  • Hot Plate
  • Inverted Grid Hang
  • Olfactory Habituation
  • Open Field Activity
  • Pole Test
  • Rotarod
  • Running Wheels (Wireless/Manual)
  • Startle/Prepulse Inhibition
  • Tail Flick
  • Visual Cliff

Social Tests

  • Direct Social Interaction
  • Emotional Contagion
  • Resident Intruder
  • Mating Behavior
  • Pup Retrieval
  • Social Approach
  • Social Memory
  • Social Novelty
  • Social Recognition
  • Transmission of Food Preference


  • Seizure Thresholds
  • Custom Designs

As a part of Gladstone, an independent nonprofit entity, the Behavioral Core offers prices that are lower than market and compare favorably with other service providers in the Bay Area. Recharge rates are based on the cost of services rendered.

For more information, contact Jeff Simms.


Projects are scheduled through iLab. Contact Jeff Simms to register for iLab.

Once a project is submitted, the core management team will schedule the desired assessments.


Neurons require glucose uptake and glycolysis in vivo. Li H, Guglielmetti C, Sei YJ, et al. (2023) Cell Reports. Apr 6;42(4):112335. doi: 10.1016/j.celrep.2023.112335.

Enhancing GAT-3 in thalamic astrocytes promotes resilience to brain injury in rodents. Cho FS, Vainchtein ID, Voskobiynyk Y, et al. (2022) Sci Transl Med. Jul 6;14(652):eabj4310. doi: 10.1126/scitranslmed.abj4310.

TAU ablation in excitatory neurons and postnatal TAU knockdown reduce epilepsy, SUDEP, and autism behaviors in a Dravet syndrome model. Shao E, Chang CW, Li Z et al. (2022) Sci Transl Med. Apr 27, 14(642) doi: 10.1126/scitranslmed.abm5527

Kv1.1 preserves the neural stem cell pool and facilitates neuron maturation during adult hippocampal neurogenesis. Lin King YH, Chen C, Lin King JV, et al. (2022) PNAS. May 31;119(22):e2118240119. doi: 10.1073/pnas.2118240119.

Mouse midbrain dopaminergic neurons survive loss of the PD-associated mitochondrial protein CHCHD2. Nguyen MK, McAvoy K, Liao SC, et al. (2022) Hum Mol Genet. May 4;31(9):1500-1518. doi: 10.1093/hmg/ddab329.

Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome. Arguello A, Meisner R, Thomsen ER, et al. (2021) JCI Insight. Oct 8;6(19):e145445. doi: 10.1172/jci.insight.145445

Interdependence of neural network dysfunction and microglial alterations in Alzheimer's disease-related models. Das M, Mao W, Shao E, et al. (2021) iScience. Oct 7;24(11):103245. doi: 10.1016/j.isci.2021.103245.

Phenotypic Differences between the Alzheimer's Disease-Related hAPP-J20 Model and Heterozygous Zbtb20 Knock-Out Mice. Gulbranson DR, Ho K, Yu GQ, et al. (2021) eNeuro. May 13;8(3):ENEURO.0089-21.2021. doi: 10.1523/ENEURO.0089-21.2021.

Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity. Shields LY, Li H, Nguyen K, et al. (2021) J Biol Chem. Jan-Jun;296:100469. doi: 10.1016/j.jbc.2021.100469. Epub 2021 Feb 25.

Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1. Johnson ECB, Ho K, Yu GQ, et al. (2020) Mol Neurodegener. Sep 14;15(1):53. doi: 10.1186/s13024-020-00393-5.

Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit. Diaz-Alonso J, Morishita W, Incontro S, et al. (2020) eLife. 2020;9:e58042 doi: 10.7554/eLife.58042

Tau Reduction Prevents Key Features of Autism in Mouse Models. Tai C, Chang CW, Yu GQ, et al. (2020) Neuron. 106(3):421–437.e11. doi:10.1016/j.neuron.2020.01.038

GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models. Hanson JE, Ma K, Elstrott J, et al. (2020) Cell Rep. 30(2):381–396.e4. doi:10.1016/j.celrep.2019.12.030

TMEM16B Calcium-Activated Chloride Channels Regulate Action Potential Firing in Lateral Septum and Aggression in Male Mice. Wang L, Simms J, Peters CJ, et al. (2019) J Neurosci. 39(36):7102–7117. doi:10.1523/JNEUROSCI.3137–18.2019

TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala. Li KX, He M, Ye W, et al. (2019) Elife. 8:e47106. Published 2019 Sep 4. doi:10.7554/eLife.47106

Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model. Merlini M, Rafalski VA, Rios Coronado PE, et al. (2019) Neuron. 101(6):1099-1108.e6. doi:10.1016/j.neuron.2019.01.014

Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer's Disease Mouse Model. Jones EA, Gillespie AK, Yoon SY, Frank LM, Huang Y. (2019) Cell Rep. 29(8):2123–2133.e4. doi:10.1016/j.celrep.2019.10.056

CX3CR1-CCR2-dependent monocyte-microglial signaling modulates neurovascular leakage and acute injury in a mouse model of childhood stroke. Faustino J, Chip S, Derugin N, et al. (2019) J Cereb Blood Flow Metab. 39(10):1919–1935. doi:10.1177/0271678X18817663

Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Vainchtein ID, Chin G, Cho FS, Kelley KW, Miller JG, Chien EC, Liddelow SA, Nguyen PT, Nakao-Inoue H, Dorman LC, Akil O, Joshita S, Barres BA, Paz JT, Molofsky AB, Molofsky AV. (2018) Science. 359(6381):1269–1273. PMID:29420261.

Nav1.1-Overexpressing interneuron transplants restore brain rhythms and cognition in a mouse model of Alzheimer’s Disease. Martinez-Losa M, Tracy TE, Ma K, Verret L, Clemente-Perez A, Khan AS, Cobos I, Ho K, Gan L, Mucke L, Alvarez-Dolado M, Palop J. (2018) Neuron. 98:75–89. PMID:29551491.

Istradefylline reduces memory deficits in aging mice with amyloid pathology. Orr AG, Lo I, Schumacher H, Ho K, Gill M, Guo W, Kim D, Knox A, Saito T, Saido TC, Simms J, Toddes C, Wang X, Yu G, Mucke L. (2018) Neurobiology of Disease. 110:29–36. PMID: 29100987.

Gastric corticotropin-releasing factor influences mast cell infiltration in a rat model of functional dyspepsia. Hagiwara S-i, Kaushal E, Paruthiyil S, Pasricha PJ, Hasdemir B, Bhargava A (2018) PLoS ONE. 13(9): e0203704. PMID:30192883.

Fast-spiking interneurons supply feedforward control of bursting, Calcium, and plasticity for efficient learning. Owen SF, Berke JD, Kreitzer AC. (2018) Cell. 172 (4):689–695. PMID:29425490.

Ovarian cycle stages modulate Alzheimer-related cognitive and brain network alterations in female mice. Broestl L, Worden K, Moreno AJ, Davis EJ, Wang D, Garay B, Singh T, Verret L, Palop JJ, Dubal DB. (2018) eNeuro. 5(6): ENEURO.0132–17.2018. PMID: 30627643.

SIRT1 deacetylates tau and reduces pathogenic tau spread in a mouse model of tauopathy. Min SW, Sohn PD, Li Y, Devidze N, Johnson JR, Krogan N, Masliah E, Mok SA, Getwicki JE, Gan L. (2018) J. Neuroci. 38(15):3680–3688. PMID:29540553.

Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson’s disease. Orr AL, Rutaganira FU, de Roulet D, Huang EJ, Hertz NT, Shokat KM, Nakamura K. (2017) Neurochemistry International. 109:106–116. PMID:28434973.

PAFAH1B1 haploinsuffieiency disrupts GABA neurons and synaptic E/I balance in the dentate gyrus. Dinday MT, Girskis KM, Lee S, Baraban SC, Hunt RF. (2017) Scientific Reports. 7:Article number:8269. PMID: 28811646.

Ketogenic diet reduces midlife mortality and improves memory in aging mice. Newman JC, Covarrubias AJ, Zhao M, Yu X, Gut P, Ng CP, Huang Y, Halder S, Verdin E. (2017) Cell Metabolism. 26(3):247–557. PMID:28877458.

Microglial NFkB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia. Krabbe G, Minami SS, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC, Sayed F, Merlini M, Ward ME, Perry DC, Lee SF, Sias S, Parkhurst CN, Gan WB, Akassoglou K, Miller BL, Fares RV Jr, Gan L. (2017) PNAS. 114(19):5029–5034. PMID: 28438992.

Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice. Leon J, Moreno AJ, Garay BI, Chalkley RJ, Burlingame AL, Wang D, Dubal D. (2017) Cell Reports. 20(6):1360–1371. PMID:28793260.

Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome. Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A. (2017) Science Signaling. 9(431):ra58. PMID:27273096.

A small molecule targeting protein translation does not rescue spatial learning and memory deficits in the hAPP-J20 mouse model of Alzheimer’s disease. Johnson ECB, Kang J. (2016) PeerJ. 4:e2565. PMID:27781164.

Serine 421 regulates mutant huntingtin toxicity and clearance in mice. Kratter IH, Zahed H, Lau A, Tsvetkov AS, Daub AC, Welberth KF, Gu X, Saudou F, Humbert S, Yang XW, Osmand A, Steffan JS, Masliah E, Finkbeiner S. (2016) J. Clin. Invest. 126:3585–3597. PMID: 27525439

Acetylated tau obstructs KIBRA-mediated signaling in synaptic plasticity and promotes tauopathy-related memory loss. Tracy TE, Sohn PD, Minami SS, Wang C, Min SW, Zhou Y, Li Y, Le D, Lo I, Ponnusamy R, Cong X, Schilling B, Ellerby L, Huganir RL, Gan L. (2016) Neuron. 90:245–260. PMID:27041503

αβ-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington’s disease. Oliveira AO, Osmand A, Outeiro TF, Muchowski PJ, Finkbeiner S. (2016) Hum. Mol. Genet. 25:1677–1689. PMID:26920069

Enhancing GABA signalling during middle adulthood prevents age-dependent GABAergic interneuron decline and learning and memory deficits in ApoE4 mice. Tong LM, Yoon SY, Andrews-Zwilling Y, Yang A, Lin V, Lei H, Huang Y. (2016) J. Neurosci. 36:2316–2322. PMCID:PMC4756160

Prenatal β-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors. Belinson H, Nakatani J, Babineau B, Bimbaum RY, Ellegood J, Bershteyn M, McEvilly RJ, Long JM, Willert K, Klein OD, Ahituv N, Lerch JP, Rosenfeld MG, Wynshaw-Boris A. (2016) Mol. Psychiatry. 21:1417–1433. PMID:26830142

Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice. Maeda S, Djukic B, Taneja P, Yu G-Q, Lo I, Davis A, Craft R, Guo W, Wang X, Kim D, Ponnusamy R, Gill TM, Masliah E, Mucke L. (2016) EMBO Rep. 17:530–551. PMID:26931567

Network dysfunction in alpha-synuclein transgenic mice and human Lewy body dementia. Morris M, Sanchez PE, Verret L, Beagle AJ, Guo W, Dubal D, Ranasinghe KG, Koyama A, Ho K, Yu GQ, Vossel KA, Mucke L. (2015) Ann. Clin. Transl. Neurol. 16:1012–1028. PMID: 26732627

Cross-species translation of the Morris maze for Alzheimer’s disease. Possin KL, Sanchez PE, Anderson-Bergman C, Fernandez R, Kerchner GA, Johnson ET, Bott N, Keily T, Fenesy MC, Miller BL, Kramer JH, Finkbeiner S. (2015) J. Clin. Invest. 126:779–783. PMCID:PMC4731157

DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice. Suberbielle E, Djukic B, Evans M, Kim DH, Taneja P, Wang X, Finucane M, Knox J, Ho K, Devidze N, Masliah E, Mucke L. (2015) Nat. Commun. 6:8897. PMID:26615780

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L. (2015) Nat. Med. 21:1154–1162. PMID:26390242

Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists. Minami SS, Shen V, Le D, Krabbe G, Asgarov R, Perez-Celajes L, Lee CH, Donnelly-Roberts D, Gan L. (2015) Biochem. Pharm. 15:454–462. PMID:26206194

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory. Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu G-Q, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L. (2015) Nat. Neurosci. 18:423–434. PMID:25622143

Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice. Dubal DB, Zhu L, Sanchez PE, Worden K, Broestl L, Johnson E, Ho K, Yu GQ, Kim D, Betourne A, Kuro-o M, Masliah E, Abraham CR, Mucke L. (2015) J. Neuroci. 35:2358–2371. PMID:25673831

Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons. Shields LY, Kim H, Zhu L, Haddad D, Berthet A, Pathak D, Lam M, Ponnusamy R, Diaz-Ramirez LG, Gill TM, Sesaki H, Mucke L, Nakamura K. (2015) Cell Death Dis. 6:e1725. PMID:25880092

Sex-dependent changes in metabolism and behavior, as well as reduced anxiety after eliminating ventromedial hypothalamus excitatory output. Cheung CC, Krause WC, Edwards RH, Yang CF, Shah NM, Hnasko TS, Ingraham HA. (2015) Mol Metab. 4(11):857–66. PMID:26629409.

SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration through epigenetic regulation of IL-1b. Cho SH, Ward ME, Coppola G, Krabbe G, Sohn PD, Masliah E, Zhou Y, Suberbielle E, Minami SS, and Gan L. (2015) J. Neurosci. 35:807–818. PMCID:PMC4293425

Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice. Cheng JS, Craft R, Yu G-Q, Ho K, Wang X, Mohand G, Mangnitsky S, Ponnusamy R, Mucke L. (2014) PLoS ONE. 9:1–17. PMCID:PMC4281043

Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice. Knoferle J, Yoon SY, Walker D, Leung L, Gillespie AK, Tong LM, Bien-Ly N, Huang Y. (2014) J. Neurosci. 34:14069–14078. PMCID:PMC4198545

Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. Berthet A, Margolis EB, Zhang J, Hsieh I, Zhang J, Hnasko TS, Ahmad J, Edwards RH, Sesaki H, Huang EJ, Nakamura K. (2014) J. Neurosci. 34:14304–14317. PMCID:PMC4205554

Progranulin protects against amyloid beta deposition and toxicity in Alzheimer's disease mouse models. Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L, Farese RV, Jr., Gan L. (2014) Nat. Med. 20:1157–1164. PMCID:PMC4196723

Tau reduction prevents disease in a mouse model of Dravet syndrome. Gheyara AL, Ponnusamy R, Djukic B, Craft RJ, Ho K, Guo W, Finucane MM, Sanchez PE, Mucke L. (2014) Ann Neurol. 76:443–456. PMCID:PMC4338764.

Life extension factor klotho enhances cognition. Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D, Klein E, Yu GQ, Ho K, Eilertson KE, Yu L, Kuro-o M, De Jager PL, Coppola G, Small GW, Bennett DA, Kramer JH, Abraham CR, Miller BL, Mucke L. (2014) Cell Rep. 7:1065–1076. PMCID:PMC4176932

Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Abeta accumulation. Tong LM, Djukic B, Arnold C, Gillespie AK, Yoon SY, Wang MM, Zhang O, Knoferle J, Rubenstein JL, Alvarez-Buylla A, Huang Y. (2014) Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Abeta accumulation. J. Neurosci. 34:9506–9515. PMCID:PMC4099537

Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model. Heng MY, Lin ST, Verret L, Huang Y, Kamiya S, Padiath QS, Tong Y, Palop JJ, Huang EJ, Ptacek LJ, Fu YH. (2013) J. Clin. Invest. 123:2719–2729. PMCID:PMC3668844

Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice. Morris M, Hamto P, Adame A, Devidze N, Masliah E, Mucke L. (2013) Neurobiol. Aging. 34:1523–1529. PMCID:PMC3596503

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β. Suberbielle E, Sanchez PE, Kravitz AV, Wang X, Ho K, Eilertson K, Devidze N, Kreitzer AC, Mucke L. (2013) Nat. Neurosci. 16:613–621. PMCID:PMC3637871

Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. Andrews-Zwilling Y, Gillespie AK, Kravitz AV, Nelson AB, Devidze N, Lo I, Yoon SY, Bien-Ly N, Ring K, Zwilling D, Potter GB, Rubenstein JL, Kreitzer AC, Huang Y. (2012) PLoS One. 7:e40555. PMCID:PMC3390383

Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice. Bien-Ly N, Gillespie AK, Walker D, Yoon SY, Huang Y. (2012) J. Neurosci. 32:4803–4811. PMCID:PMC3433173

Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington's disease. Bouchard J, Truong J, Bouchard K, Dunkelberger D, Desrayaud S, Moussaoui S, Tabrizi SJ, Stella N, Muchowski PJ. (2012) J. Neurosci. 32:18259–18268. PMCID:PMC3753072

Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits. Harris JA, Koyama A, Maeda S, Ho K, Devidze N, Dubal DB, Yu G-Q, Masliah E, Mucke L. (2012) PLoS One. 7:e45881. PMCID:PMC3454317

Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development. Jain S, Yoon SY, Zhu L, Brodbeck J, Dai J, Walker D, Huang Y. (2012) PLoS One. 7:e46340. PMCID:PMC3457985

Bone marrow transplantation confers modest benefits in mouse models of Huntington's disease. Kwan W, Magnusson A, Chou A, Adame A, Carson MJ, Kohsaka S, Masliah E, Moller T, Ransohoff R, Tabrizi SJ, Bjorkqvist M, Muchowski PJ. (2012) J. Neurosci. 32:133–142. PMCID:PMC3571858

Genetic deficiency of complement component 3 does not alter disease progression in a mouse model of Huntington's disease. Larkin PB, Muchowski PJ. (2012) J. Huntingtons Dis. 1:107–118. PMCID:PMC3478099

RGS4 is required for dopaminergic control of striatal LTD and susceptibility to parkinsonian motor deficits. Lerner TN, Kreitzer AC. (2012) Neuron. 73:347–359. PMCID:PMC3269032

Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice. Leung L, Andrews-Zwilling Y, Yoon SY, Jain S, Ring K, Dai J, Wang MM, Tong L, Walker D, Huang Y. (2012) PLoS One. 7:e53569. PMCID:PMC3534053

Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Ring KL, Tong LM, Balestra ME, Javier R, Andrews-Zwilling Y, Li G, Walker D, Zhang WR, Kreitzer AC, Huang Y. (2012) Cell Stem Cell. 11:100–109. PMCID:PMC3399516

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model. Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Ho K, Yu G-Q, Palop JJ, Mucke L. (2012) Proc. Natl. Acad. Sci. USA. 109:E2895–E2903. PMCID:PMC3479491

Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model. Verret L, Mann EO, Hang GB, Barth AM, Cobos I, Ho K, Devidze N, Masliah E, Kreitzer AC, Mody I, Mucke L, Palop JJ. (2012) Cell. 149:708–721. PMCID:PMC3375906

C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-β (Aβ) and acts in concert with Aβ to elicit neuronal and behavioral deficits in mice. Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Wang C, Huang Y. (2011) Proc. Natl. Acad. Sci. USA. 108:4236–4241. PMCID:PMC3053957

CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease. Cho SH, Sun B, Zhou Y, Kauppinen TM, Halabisky B, Wes P, Ransohoff RM, Gan L. (2011) J. Biol. Chem. 286:32713–32722. PMCID:PMC3173153

Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice. Cisse M, Sanchez PE, Kim DH, Ho K, Yu GQ, Mucke L. (2011) J. Neurosci. 31:10427–10431. PMCID:PMC3314063

Tau reduction does not prevent motor deficits in two mouse models of Parkinson’s disease. Morris M, Koyama A, Masliah E, Mucke L. (2011) PLoS One. 6:e29257. PMCID:PMC3242771

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. Zwilling D, Huang SY, Sathyasaikumar KV, Notarangelo FM, Guidetti P, Wu HQ, Lee J, Truong J, Andrews-Zwilling Y, Hsieh EW, Louie JY, Wu T, Scearce-Levie K, Patrick C, Adame A, Giorgini F, Moussaoui S, Laue G, Rassoulpour A, Flik G, Huang Y, Muchowski JM, Masliah E, Schwarcz R, Muchowski PJ. (2011) Cell. 145:863–874. PMCID:PMC3118409

Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer’s disease. Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu GQ, Palop JJ, Noebels JL, Mucke L. (2011) J Neuroscience. 31(2):700–71. PMID:21228179.

Blocking early GABA depolarization with bumetanide results in permanent alterations in cortical circuits and sensorimotor gating deficits. Wang DD, Kriegstein AR. (2011) Cerebral Cortex. 21(3):574–587. PMID:20624842.

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model. Cisse M, Halabisky B, Harris J, Devideze N, Dubal D, Sun B, Orr A, Lotz G, Kim DH, Hamto P, Ho K, Yu GQ, Mucke L. (2011) Nature. 469:47–52. PMID:21113149.

Apolipoprotein E4 causes age- and tau-dependent impairment of GABA-ergic interneurons, leading to learning and memory deficits in mice. Andrews-Zwilling Y, Bien-Ly N, Xu Q, Li G, Bernardo A, Yoon SY, Zwilling D, Yan TX, Chen L, Huang Y. (2010) J of Neuroscience. 30(41):13707–13717. PMID: 20943911.

Arc regulates spine morphology and maintains network stability in vivo. Peeples CL, Yoo J, Thwin, Palop JJ, Noebels JL, Finkbeiner S. (2010) 107(42):18173–18178. PMID:20921410.

Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network. Harris JA, Devidze N, Verret L, Ho K, Thwin MT, Kim D, Hamto P, Lo I, Yu GQ, Palop JJ, Masliah E, Mucke L. (2010). Neuron. 68(3):428–441. PMID:21040845.

Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer’s disease are independent of caspase cleavage of the amyloid precursor protein. Harris JA, Devidze N, Halabisky B, Lo I, THwin MT, Yu GQ, Bredesen DE, Masliah E, Mucke L. (2010) J of Neuroscience. 30(1):372–381. PMID:20053918.

Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice. Meilandt WJ, Cisse M, Ho K, Wu T, Esposito LA, Scearce-Levi K, Cheng IH, Yu GQ, Mucke L. (2009) J of Neuroscience. 29(&):1977–1986. PMID:19228952

Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer’s disease. Sun B, Zhou Y, Halabisky B, Lo I, Cho SH, Mueller-Steiner S, Devidze N, Wang X, Grubb A, Gan L. (2008) Neuron. 60(2):247–57. PMID:18957217.

Apolipoprotein E4 domain interaction: Synaptic and cognitive deficits in mice. Zhong N, Scearce-Levie K, Ramaswamy G, Weisgrabber KH (2008) Alzheimer’s & Dementia. 4(3):179–192. PMID:18631967.

Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer’s disease. Sanchez-Mejia RO, Newman JW, Toh S, Yu GQ, Zhou Y, Halabisky B, Cisse M, Scearce-Levie K, Cheng IH, Gan L, Palop JJ, Bonventre JV, Mucke L. (2008) Nature Neuroscience. 11(11):1311–8. PMID:18931664.

Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer’s disease. Meilandt WJ, Yu GQ, Chin J, Roberson ED, Palop JJ, Wu T, Scearce-Levie K, Muck L. (2008) Journal of Neuroscience. 28(19):5007–17. PMID:18463254.

Abnormal social behaviors in mice lacking Fgf17Genes. Scearce-Levie K, Roberson ED, Gerstein H, Cholfin JA, Mandiyan VS, Shah NM, Rubenstein JL, Mucke L. (2008) Brain Behav. 7(3):344–54. PMID:17908176.

Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puolivali J, Lesne S, Ashe KH, Muchowski PJ, Mucke l. (2007) J Biol Chem. 282(33):23818–28. PMID:17548355.

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer’s disease mouse model. Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L. (2007) Science. 316(5825):750–4.

Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice. Esposito L, Raber J, Kekonius L, Yan F, Yu GQ, Bien-Ly N, Puoliväli J, Scearce-Levie K, Masliah E, Mucke L. (2006) J of Neuroscience. 26(19):5167–79. PMID:16687508.

Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease. Chin J, Palop JJ, Puoliväli J, Massaro C, Bien-Ly N, Gerstein H, Scearce-Levie K, Masliah E, Mucke L. (2005) J of Neuroscience. 25(42):9694–703. PMID:16687508.

Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y. (2003) Proc Natl Acad Sci U S A. 100(19):10966–71. PMID: 12939405.

The Autism-Associated Gene Scn2a Contributes to Dendritic Excitability and Synaptic Function in the Prefrontal Cortex. Spratt PWE, Ben-Shalom R, Keeshen CM, et al. (2019) Neuron. Aug 21;103(4):673-685.e5. doi: 10.1016/j.neuron.2019.05.037. Epub 2019 Jun 20.

Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice. Leon J, Moreno AJ, Garay BI, et al. (2017) Cell Reports. Aug 8;20(6):1360-1371. doi: 10.1016/j.celrep.2017.07.024.

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Are Project Consultations Available?

Yes. The earlier we can meet with our users, the better. We find that when we’re involved in the early planning stages, we can help design studies that produce more robust and reproducible outcomes.

How Do I Initiate a Project?

Projects can be initiated through iLab. Contact Jeff Simms to register for iLab and receive detailed instruction on project submission.

Do You Offer Training for Those Who Would Like to Run Their Own Experiments?

Yes. We are more than happy to train anyone who would like to learn how to perform behavioral assessments. Once fully trained, you will be able to run your own experiments with the continued support from the core staff.

Do You Offer Data Analysis Assistance?

The core provides a complete service package, including data compilation and analysis. The data package is designed to be ready for publication and we provide support throughout the publication process.

Can You Help With Novel Areas of Study Without Established Behavioral Paradigms?

We often work with researchers to adapt existing protocols or create novel paradigms to best answer individual research questions. These are often the most exciting and interesting projects for our team.