The Bioinformatics Core provides expertise on experimental design and analysis of complex data sets, with a specialization on large-scale data sets acquired from various cutting-edge technologies. Make the core part of your team for experimental design, sequence analysis, pathway and network analysis, training, and grant proposals.


Bioinformatics Core Staff


Services Provided

  • Consultation on various topics, including experimental design, power analysis, bioinformatics, and statistical analysis
  • Collaboration, grant writing, and publications
  • Analysis of bulk RNA-seq, single-cell RNA-seq, ChIP-seq, ATAC-seq, and other epigenetics analysis. For sample preparation, library preparation and sequencing,
  • Integrated analysis including various data modalities
  • Network and pathway analysis, modeling, and data visualization
  • Training and workshops on topics in bioinformatics, statistics, and data science

Core Members

Ayushi Agrawal
Bioinformatician II

Natalie Elphick
Bioinformatician I

Kristina Hanspers
Senior Research Associate

Alex Pico
Core Director/Research Investigator

Min-gyoung Shin
Bioinformatician III

Reuben Thomas
Associate Core Director

Michela Traglia
Statistician III

Yihang Xin
Software Engineer II

Zainab Yusuf-Sada
Executive Administrator


The Gladstone Data Science Training Program was started in 2018 to provide trainees with learning opportunities and hands-on workshops to improve their skills in bioinformatics and computational analysis.

Upcoming Events

Our team consists of several individuals with formal training in statistics, bioinformatics, and computer science, and should be able handle almost any question that involves experimental design, bioinformatics, statistical analysis, programming, or figure generation.


We offer consulting on experimental design, analysis planning and statistical methodology, as well as on training and software development.

We also team up in analyzing your primary data. We have broad and deep experience with most forms of sequencing data and omics data. We also regularly work with genotype and phenotype data in multivariate analysis.


We can assist with Integrating data across batches and types or with publicly available data. Our methods include customized statistical modeling and network analysis.

We have expertise in visualizing data for both exploratory and publication-ready applications. In addition to figures, we routinely generate detailed pathway models and interactive web displays.


Our team has over a decade of experience developing open source software and methods, including algorithms, pipelines and custom scripts, along with software packages and applications with global usage.

We are committed to training researchers in the ways of bioinformatic analysis, statistics and programming. We conduct multiple campus-wide workshops each month as well as tailored training events for individual labs.


All service projects are coordinated through the iLabs system. Register for an account and then log in to iLabs to initiate your request. You can contact us with a brief description of your project at In addition to fee-for-service work, we also routinely work as collaborators by percent effort on grant subawards.


Gladstone $115 per hour
UCSF $190 per hour
External $230 per hour

Our core staff are career scientists too! We often make substantial contributions to projects leading to co-authorship and collaborations on grant applications. For basic routine analysis, we request acknowledgement in publications, e.g. “We thank Dr. XYZ of the Gladstone Bioinformatics Core for their assistance with statistical and bioinformatics analysis.”

Single Cell Multi-Modal Analyses Reveal Epigenomic and Transcriptomic Basis Underlying Cardiac Defects in Maternal Diabetes

T Nishino, S Ranade, P Angelo, BJ van Soldt, L Ye, M Alexanian, ...
Circulation 146 (Suppl_1), A14797-A14797, 2022

Transcription Factor GATA4 Regulates Cell Type–Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripoten...

L Zhu, K Choudhary, B Gonzalez-Teran, YS Ang, R Thomas, NR Stone, ...
Circulation, CIRCULATIONAHA. 121.057620, 2022

Enhancing GAT-3 in thalamic astrocytes promotes resilience to brain injury in rodents

FS Cho, ID Vainchtein, Y Voskobiynyk, AR Morningstar, F Aparicio, ...
Science translational medicine 14 (652), eabj4310, 2022

Differential Etv2 threshold requirement for endothelial and erythropoietic development

T Sinha, KL van Bueren, DE Dickel, I Zlatanova, R Thomas, CO Lizama, ...
Cell Reports 39 (9), 110881, 2022

Transcription factor protein interactomes reveal genetic determinants in heart disease

B Gonzalez-Teran, M Pittman, F Felix, R Thomas, D Richmond-Buccola, ...
Cell, 2022

Brahma safeguards canalization of cardiac mesoderm differentiation

SK Hota, KS Rao, AP Blair, A Khalilimeybodi, KM Hu, R Thomas, K So, ...
Nature, 1-6, 2022

Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure

RRE Abouleisa, ABM Salama, Q Ou, XL Tang, M Solanki, Y Guo, Y Nong, ...
Circulation, 2022

NDEx IQuery: a multi-method network gene set analysis leveraging the Network Data Exchange

RT Pillich, J Chen, C Churas, D Fong, BM Gyori, T Ideker, K Karis, SN Liu, ...
bioRxiv, 2022

A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors

AL Krup, SAB Winchester, SS Ranade, A Agrawal, WP Devine, T Sinha, ...
bioRxiv, 2022

Cell Layers: uncovering clustering structure in unsupervised single-cell transcriptomic analysis

AP Blair, RK Hu, EN Farah, NC Chi, KS Pollard, PF Przytycki, IS Kathiriya, ...
Bioinformatics Advances 2 (1), vbac051, 2022


M Montano, JK Ryu, EG Sozmen, K Dixit, Y Matsui, Y Liu, EWA Helmy, ...
Topics in Antiviral Medicine, 9-9, 2022

COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms

M Ostaszewski, A Niarakis, A Mazein, I Kuperstein, R Phair, ...
Molecular systems biology 17 (10), e10387, 2021

BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis

MA Petersen, R Tognatta, A Meyer-Franke, EA Bushong, AS Mendiola, ...
Brain, 2021

Ten simple rules for creating reusable pathway models for computational analysis and visualization

K Hanspers, M Kutmon, SL Coort, D Digles, LJ Dupuis, F Ehrhart, F Hu, ...
PLOS Computational Biology 17 (8), e1009226, 2021

scNetViz: from single cells to networks using Cytoscape

K Choudhary, EC Meng, JJ Diaz-Mejia, GD Bader, AR Pico, JH Morris
F1000Research 10 (448), 448, 2021

Comparison of Developmental Dynamics in Human Fetal Retina and Human Pluripotent Stem Cell-Derived Retinal Tissue

RK Singh, PA Winkler, F Binette, SM Petersen-Jones, IO Nasonkin
Stem Cells and Development 30 (8), 399-417, 2021

More Publications


FAQs section intro text here....

How Do I Schedule an Initial Meeting?

What If I Just Have a Quick Question?

Does the Bioinformatics Core Have Suggested Pipelines to Process, Run Quality Control Checks Etc. on Sequencing Data of Different Kinds (RNA-seq, Chip-seq, Atac-seq)?

We recommend Nextflow pipelines, which we have configured to run on the UCSF-Wynton compute cluster.

How Should I Acknowledge Minor Contributions to a Paper?

We commonly contribute at the level of co-authors, but for minor contributions an acknowledgement is much appreciated, e.g., We thank Dr. XYZ of the Gladstone Bioinformatics Core for their assistance with statistical and bioinformatics analysis.