News

Article November 9, 2023

New Tool Unsnarls DNA-Winding Mystery, with Likely Implications for Many Diseases

A novel method developed by Gladstone researchers is already answering longstanding questions about basic DNA dynamics—and may one day lead to new ways of treating cancer and other conditions

News Release Research (Publication) Data Science and Biotechnology Ramani Lab Big Data

Article October 20, 2023

Study on Largest Genetic Risk Factor for Alzheimer’s Points Toward New Drug Target

Gladstone researchers discovered how the ApoE4 gene variant makes neurons release an inflammatory signaling molecule—and how blocking that release could prevent or treat Alzheimer’s disease

News Release Research (Publication) Alzheimer’s Disease Neurological Disease Huang Lab

Article September 14, 2023

Lego-Like Gene Editing Tool Lets Researchers Improve Cancer Immunotherapy

Scientists used a new method to screen 10,000 combinations of gene edits in immune cells engineered to fight cancer

News Release Research (Publication) Cancer Genomic Immunology Marson Lab CRISPR/Gene Editing

Article August 30, 2023

How Unique Immune Cells Can Recognize—and Destroy—Tumors

New study explains how understudied cells in the immune system, called gamma delta T cells, can target cancer cells for destruction

News Release Research (Publication) Cancer Genomic Immunology Marson Lab

Article August 17, 2023

The Best Thing Since Sliced Tissue

A new tool created by Gladstone researchers aligns data from tissue slices virtually, expanding possibilities for 3D analysis

News Release Research (Publication) Data Science and Biotechnology Engelhardt Lab Big Data

Article August 2, 2023

“A Molecular Biology Tour de Force:” Pinpointing a Heart-Protective DNA Change

A Q&A with researchers Bruce Conklin and Juan Perez-Bermejo

Research (Publication) Mass Spectrometry Facility Heart Failure Data Science and Biotechnology Conklin Lab Krogan Lab Stem Cells/iPSCs

Article July 17, 2023

A Key Function for Tight Junctions in Embryo Models

Barriers between stem cells play a crucial role in human development—and offer a new potential route for fertility treatment

News Release Research (Publication) iPS Cell Research Center Yamanaka Lab Stem Cells/iPSCs

Article July 10, 2023

How Understanding RNA Structure Can Help Researchers Design Better HIV Drugs

New research sheds light on the biological effect of the many possible three-dimensional structures of a critical loop of RNA in HIV

Research (Publication) HIV/AIDS Virology Ott Lab

Article June 8, 2023

Revealing How Blood Triggers Brain Disease

New research into how blood makes the brain’s immune cells toxic points to new treatments for Alzheimer’s disease and multiple sclerosis

News Release Research (Publication) Multiple Sclerosis Alzheimer’s Disease Center for Neurovascular Brain Immunology Neurological Disease Akassoglou Lab Krogan Lab Pico

Article May 31, 2023

Artificial Intelligence System Predicts Consequences of Gene Modifications

Researchers trained a computer model to understand the connections between thousands of genes—and pinpoint how those connections go awry in human disease

News Release Research (Publication) Cardiovascular Disease Theodoris Lab

Article April 27, 2023

Study Suggests Catalyst for Human Brain Evolution

Large structural changes to the genomes of human ancestors could have spurred the smaller changes that set human brains apart from other primates

News Release Research (Publication) Data Science and Biotechnology Pollard Lab

Article April 18, 2023

Sugar Rush: Scientists Discover Key Role of Glucose in Brain Activity

New details on how healthy neurons metabolize glucose have implications for understanding neurodegenerative diseases

News Release Research (Publication) Parkinson’s Disease Alzheimer’s Disease Neurological Disease Nakamura Lab

Article March 17, 2023

Can Lymph Nodes Boost the Success of Cancer Immunotherapy?

New data show therapies may activate lymph nodes to produce tumor-tackling T cells

News Release Research (Publication) Cancer Genomic Immunology Spitzer Lab

Article March 8, 2023

Researchers Discover How Too Much Oxygen Damages Cells and Tissues

High levels of oxygen can cause lasting health problems in humans. Now scientists know why.

News Release Research (Publication) Cardiovascular Disease Jain Lab CRISPR/Gene Editing

Article March 7, 2023

How High Altitude Changes Your Body’s Metabolism

When mice are exposed to chronically low levels of oxygen, similar to those experienced at 4,500 meters of elevation, their metabolism changes

News Release Research (Publication) Cardiovascular Disease Jain Lab