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Scientists Leverage Machine Learning to Decode Gene Regulation in the Developing Human Brain

scientists at Gladstone Institutes and University of California, San Francisco
Article May 24, 2024

Scientists Leverage Machine Learning to Decode Gene Regulation in the Developing Human Brain

A team of researchers from Gladstone Institutes and UC San Francisco combined high-throughput experiments and machine learning to analyze more than 100,000 sequences in human brain cells.

News Release Research (Publication) Data Science and Biotechnology Pollard Lab AI Big Data Developmental Biology Disease Models Genomics Human Genetics

The Blood Holds Clues to Understanding Long COVID

Gladstone in the News March 4, 2024

The Blood Holds Clues to Understanding Long COVID

Science News—In some people with long COVID, powerful immune players called T cells seem to go out of whack. In some long COVID patients, T cells that recognize SARS-CoV-2 can become exhausted, Nadia Roan's team reported in Nature Immunology in January. And scientists know that tired-out T cells can have trouble wiping out infection.

Research (Publication) COVID-19 Infectious Disease Roan Lab

Vote for Gladstone in This Year’s ‘STAT Madness’ Tournament

Stat Madness logo
Article March 1, 2024

Vote for Gladstone in This Year’s ‘STAT Madness’ Tournament

The health and science publication STAT has selected a breakthrough discovery from Gladstone to be part of its annual STAT Madness competition, in which research institutes compete for the title of champion. The winner is deemed the most innovative research institution in the country.

Research (Publication) Cancer Genomic Immunology Doudna Lab CRISPR/Gene Editing

Using Cancer’s ’Superpower’ to Boost T-cell Therapies in Mice

Gladstone in the News February 12, 2024

Using Cancer’s ’Superpower’ to Boost T-cell Therapies in Mice

Fierce Biotech—A naturally occurring mutation in T cells that leads to lymphoma can be weaponized to make engineered T-cell therapies more effective against cancer, including melanoma, findings from a new study in mice suggest. The study’s co-leads, dermatologist Jaehyuk Choi and scientist Kole Roybal, have launched a new biotech company called Moonlight Bio to take their findings to the clinic.

Research (Publication) Cancer Genomic Immunology Parker Institute for Cancer Immunotherapy Roybal Lab Genomics

Heart-to-Heart Connection: Exploratorium and Gladstone Bring a Breakthrough Science Exhibit to Life

Exploratorium hero image
Article February 8, 2024

Heart-to-Heart Connection: Exploratorium and Gladstone Bring a Breakthrough Science Exhibit to Life

At San Francisco’s Exploratorium, visitors sync their heartbeat with living heart cells; the first-of-its-kind exhibit was created through the museum’s long-running partnership with scientists at Gladstone Institutes.

News Release Stem Cells/iPSCs Conklin Lab Yamanaka Lab Cardiovascular Disease Research (Publication)

Turbocharged CAR-T Cells Melt Tumours in Mice—Using a Trick from Cancer Cells

Gladstone in the News February 7, 2024

Turbocharged CAR-T Cells Melt Tumours in Mice—Using a Trick from Cancer Cells

Nature—Cancer cells are the ultimate survivors, riddled with mutations that let them thrive when healthy cells would die. These same mutations can boost the ability of game-changing cell therapies to quash cancer, a study in mice shows. “Natural T-cell function isn’t good enough. We need to explore the extremes of T-cell function,” says Kole Roybal, co-author of the new paper.

Research (Publication) Cancer Genomic Immunology Parker Institute for Cancer Immunotherapy Roybal Lab Genomics

As Prescribed: Researchers Dive Into the Biology of Autism

Gladstone in the News January 18, 2024

As Prescribed: Researchers Dive Into the Biology of Autism

KCBS Radio—Diagnoses of autism spectrum disorder, or ASD, have been rising over the past decades, with one in 36 children identified with the condition in 2020 compared to one in 150 back in 2000, according to the US Centers for Disease Control and Prevention. Nevan Krogan, PhD, senior investigator at Gladstone Institutes and director of the Quantitative Biosciences Institute at UC San Francisco, shares new research on genetic changes that contribute to ASD.

Gladstone Experts Research (Publication) Neurological Disease Krogan Lab

Advancing CRISPR Applications: Here, There and Everywhere

Gladstone in the News January 16, 2024

Advancing CRISPR Applications: Here, There and Everywhere

BioTechniques—Researchers at Gladstone Institutes have mapped the human immune response using next-generation CRISPR technology known as base editing. Using this tool, the team was able to identify specific nucleotides within T cells that influence immune cells’ response to stimuli, creating maps of DNA sequences and protein sites that are involved in human immune responses. The discoveries this project has facilitated could improve existing immunotherapies and reveal new drug targets for autoimmune diseases and cancer.

Research (Publication) Autoimmune Diseases Cancer Genomic Immunology Doudna Lab Marson Lab CRISPR/Gene Editing Genomics

Cellular Clean Energy: Can Mitochondria Make More Energy Without Collateral Damage?

Gladstone staff scientist Neal Bennett and investigator Ken Nakamura working in the lab
Article January 11, 2024

Cellular Clean Energy: Can Mitochondria Make More Energy Without Collateral Damage?

New research from Gladstone may help in the development of new therapies that target the problem of cellular energy failure—a hallmark of Parkinson’s, Alzheimer’s, and aging in general

News Release Research (Publication) Alzheimer’s Disease Parkinson’s Disease Neurological Disease Nakamura Lab CRISPR/Gene Editing

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