Gladstone in the News
February 12, 2024
Fierce Biotech—A naturally occurring mutation in T cells that leads to lymphoma can be weaponized to make engineered T-cell therapies more effective against cancer, including melanoma, findings from a new study in mice suggest. The study’s co-leads, dermatologist Jaehyuk Choi and scientist Kole Roybal, have launched a new biotech company called Moonlight Bio to take their findings to the clinic.
Research (Publication)
Cancer
Genomic Immunology
Parker Institute for Cancer Immunotherapy
Roybal Lab
Genomics
Gladstone in the News
February 7, 2024
Nature—Cancer cells are the ultimate survivors, riddled with mutations that let them thrive when healthy cells would die. These same mutations can boost the ability of game-changing cell therapies to quash cancer, a study in mice shows. “Natural T-cell function isn’t good enough. We need to explore the extremes of T-cell function,” says Kole Roybal, co-author of the new paper.
Research (Publication)
Cancer
Genomic Immunology
Parker Institute for Cancer Immunotherapy
Roybal Lab
Genomics
Gladstone in the News
January 16, 2024
BioTechniques—Researchers at Gladstone Institutes have mapped the human immune response using next-generation CRISPR technology known as base editing. Using this tool, the team was able to identify specific nucleotides within T cells that influence immune cells’ response to stimuli, creating maps of DNA sequences and protein sites that are involved in human immune responses. The discoveries this project has facilitated could improve existing immunotherapies and reveal new drug targets for autoimmune diseases and cancer.
Research (Publication)
Autoimmune Diseases
Cancer
Genomic Immunology
Doudna Lab
Marson Lab
CRISPR/Gene Editing
Genomics
Gladstone in the News
April 27, 2023
New York Times—A group of studies comparing the human genome to that of 239 other mammalian species has cast light on what makes humans unique. In particular, work from Katie Pollard, director of the Gladstone Institute of Data Science and Biotechnology, shows that changes to the way DNA folds may have been a part of what allowed humans to evolve large, powerful brains.
Gladstone Experts
Data Science and Biotechnology
Pollard Lab
Genomics
Human Genetics
Gladstone in the News
April 27, 2023
Popular Science—A new study from Katie Pollard, director of the Gladstone Institute of Data Science and Biotechnology, indicates that chance structural changes in the human genome were what allowed humans to evolve the larger brains that set us apart from our primate ancestors.
Gladstone Experts
Data Science and Biotechnology
Pollard Lab
Genomics
Human Genetics
Gladstone in the News
April 5, 2023
National Institutes of Health—Senior Investigator Katie Pollard, PhD, is featured for her work on genome organization during heart development and talks about her career path in a recent highlight of the National Institutes of Health's 4D Nucleome program.
Gladstone Experts
Data Science and Biotechnology
Pollard Lab
Genomics
Gladstone in the News
October 17, 2022
National Academy of Medicine—Katie Pollard, PhD, senior investigator and director of the Gladstone Institute of Data Science and Biotechnology, has been elected to the National Academy of Medicine, in recognition of her discovery of fast-evolving regions in the human genome associated with psychiatric diseases, and of her open-source software used worldwide by genome scientists.
Gladstone Experts
Data Science and Biotechnology
Pollard Lab
Big Data
Genomics
Human Genetics
Microbiome