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Scientists develop powerful drug candidates that could head off future coronavirus pandemics.
News Release Research (Publication) COVID-19 Virology Krogan Lab Ott Lab
Bloomberg—Katerina Akassoglou, a neurovascular brain immunologist at Gladstone, and her team discovered that beyond serving as the virus’s “key” to enter cells, spike binds with a blood clotting factor called fibrinogen, causing a cascade of events that contribute to the neurological symptoms of long COVID.
COVID-19 Akassoglou Lab
Researchers discovered that the presence of autoantibodies in the nose can help fight off the virus more effectively.
Research (Publication) COVID-19 Virology Roan Lab
Gladstone’s Magnus Hoffmann seeks to advance a new generation of more effective vaccines, improved drug delivery methods, and a greater overall understanding of vaccine-induced immune responses.
COVID-19 Data Science and Biotechnology Virology
ABC7 News—The most commonly reported symptom of long COVID is brain fog, which interferes with your ability to think clearly, remember things, and focus on a task. Senior Investigator Katerina Akassoglou explains the findings from her study that shed new light on what causes brain fog and the many other brain-related symptoms of long COVID and COVID-19.
Gladstone Experts COVID-19 Akassoglou Lab
Inside Precision Medicine—A new study by Gladstone Senior Investigators Katerina Akassoglou and Warner Greene shows that fibrin, a blood coagulation protein, drives the cascade of symptoms that are the hallmarks of infection by the SARS-CoV-2 virus.
Gladstone Experts COVID-19 Akassoglou Lab
A new study in Nature overturns the prevailing theory that blood clotting is merely a consequence of inflammation in COVID-19.
News Release Research (Publication) COVID-19 Neurological Disease Virology Akassoglou Lab
San Francisco Chronicle—With the United States now experiencing a typical summer COVID surge, Gladstone Senior Investigator Nadia Roan helps break down how to make a personal decision about when to get your next vaccine.
Gladstone Experts COVID-19 Virology Roan Lab
Science News—In some people with long COVID, powerful immune players called T cells seem to go out of whack. In some long COVID patients, T cells that recognize SARS-CoV-2 can become exhausted, Nadia Roan’s team reported in Nature Immunology in January. And scientists know that tired-out T cells can have trouble wiping out infection.
Research (Publication) COVID-19 Virology Roan Lab
STAT—New research has identified proteins present in the blood of people with long COVID that could point the way to a much-needed diagnostic test and possibly to future therapeutic targets. “The dysregulation they observed is a bit complex, as some complement components go up and others go down, but overall the results suggest that complement pathways are abnormal in people with long COVID,” said Gladstone’s Nadia Roan, the senior author of a Nature Immunology paper published earlier in January on immune response in long COVID.
Gladstone Experts COVID-19 Roan Lab
San Francisco Chronicle—At least 10 percent of those who survive COVID continue to face debilitating symptoms months after the acute infection resolves. New research from the laboratory of Gladstone Senior Investigator Nadia Roan shows that individuals suffering Long Covid have a dysregulated immune response to the virus and evidence of T cell exhaustion, which may be due to the virus persisting within their bodies.
Gladstone Experts COVID-19 Virology Roan Lab
Scientists at Gladstone Institutes and UC San Francisco analyzed immune cells in people with and without long COVID, making significant discoveries that will help answer questions about what causes the condition and how to treat it
News Release Research (Publication) COVID-19 Virology Roan Lab
Melanie Ott, director of the Gladstone Institute of Virology, reflects on the breakthroughs driven by the COVID-19 pandemic and explains why virologists’ work is never done
Gladstone Experts COVID-19 Virology Ott Lab
Fortune—Researchers are investigating the possibility that people who suffer from Long COVID might be at elevated risk of developing cancer. Melanie Ott, director of the Gladstone Institute of Virology, explains that viruses related to SARS-CoV-2 have been shown to inactivate oncosuppressor proteins, which may predispose patients to cancer.
Gladstone Experts Cancer COVID-19 Virology Ott Lab
Mir Khalid, a scientist in the Ott Lab, explains his work on SARS-CoV-2, his long love of science, and how he spends his free time
Graduate Students and Postdocs Profile COVID-19 Ott Lab
