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Unraveling COVID’s Pernicious Role in Brain Fog and Clotting

Gladstone in the News November 8, 2024

Unraveling COVID’s Pernicious Role in Brain Fog and Clotting

Bloomberg—Katerina Akassoglou, a neurovascular brain immunologist at Gladstone, and her team discovered that beyond serving as the virus’s “key” to enter cells, spike binds with a blood clotting factor called fibrinogen, causing a cascade of events that contribute to the neurological symptoms of long COVID.

COVID-19 Akassoglou Lab

New Study from SF Gladstone Institutes Sheds Light on Cause of Brain Fog Due to COVID-19

Gladstone in the News September 26, 2024

New Study from SF Gladstone Institutes Sheds Light on Cause of Brain Fog Due to COVID-19

ABC7 News—The most commonly reported symptom of long COVID is brain fog, which interferes with your ability to think clearly, remember things, and focus on a task. Senior Investigator Katerina Akassoglou explains the findings from her study that shed new light on what causes brain fog and the many other brain-related symptoms of long COVID and COVID-19.

Gladstone Experts COVID-19 Akassoglou Lab

Blood Clotting Protein Discovery Upends Conventional COVID-19 Thinking, IDs Potential Therapy

Gladstone in the News August 29, 2024

Blood Clotting Protein Discovery Upends Conventional COVID-19 Thinking, IDs Potential Therapy

Inside Precision Medicine—A new study by Gladstone Senior Investigators Katerina Akassoglou and Warner Greene shows that fibrin, a blood coagulation protein, drives the cascade of symptoms that are the hallmarks of infection by the SARS-CoV-2 virus.

Gladstone Experts COVID-19 Akassoglou Lab

The Blood Holds Clues to Understanding Long COVID

Gladstone in the News March 4, 2024

The Blood Holds Clues to Understanding Long COVID

Science News—In some people with long COVID, powerful immune players called T cells seem to go out of whack. In some long COVID patients, T cells that recognize SARS-CoV-2 can become exhausted, Nadia Roan's team reported in Nature Immunology in January. And scientists know that tired-out T cells can have trouble wiping out infection.

Research (Publication) COVID-19 Virology Roan Lab

Could Long COVID’s Signs of Immune Dysregulation in the Blood Lead to a Diagnostic Test?

Gladstone in the News January 18, 2024

Could Long COVID’s Signs of Immune Dysregulation in the Blood Lead to a Diagnostic Test?

STAT—New research has identified proteins present in the blood of people with long COVID that could point the way to a much-needed diagnostic test and possibly to future therapeutic targets. “The dysregulation they observed is a bit complex, as some complement components go up and others go down, but overall the results suggest that complement pathways are abnormal in people with long COVID,” said Gladstone's Nadia Roan, the senior author of a Nature Immunology paper published earlier in January on immune response in long COVID.

Gladstone Experts COVID-19 Roan Lab

‘Striking’ Study Reveals Immune System Anomalies in People with Long COVID

Gladstone in the News January 12, 2024

‘Striking’ Study Reveals Immune System Anomalies in People with Long COVID

San Francisco Chronicle—At least 10 percent of those who survive COVID continue to face debilitating symptoms months after the acute infection resolves. New research from the laboratory of Gladstone Senior Investigator Nadia Roan shows that individuals suffering Long Covid have a dysregulated immune response to the virus and evidence of T cell exhaustion, which may be due to the virus persisting within their bodies.

Gladstone Experts COVID-19 Virology Roan Lab

Inside Long COVID’s War on the Body: Researchers Are Trying to Find Out Whether the Virus Has the Potential to Cause Cancer

Gladstone in the News November 23, 2023

Inside Long COVID’s War on the Body: Researchers Are Trying to Find Out Whether the Virus Has the Potential to Cause Cancer

Fortune—Researchers are investigating the possibility that people who suffer from Long COVID might be at elevated risk of developing cancer. Melanie Ott, director of the Gladstone Institute of Virology, explains that viruses related to SARS-CoV-2 have been shown to inactivate oncosuppressor proteins, which may predispose patients to cancer.

Gladstone Experts Cancer COVID-19 Virology Ott Lab

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