News

Gladstone in the News July 21, 2025

Two Cancer Drugs Show Surprising Promise in Treating Alzheimer’s

Discover Magazine—With so few Alzheimer’s drugs available, repurposing medications approved for other conditions could be the key to tackling this complex disease. In fact, Gladstone Investigator Yadong Huang and his colleagues at UCSF discovered that a combination of two cancer drugs could reduce brain degeneration and restore memory, pointing toward a potent treatment path never considered before.

Gladstone Experts Alzheimer’s Disease Huang Lab

Gladstone in the News July 21, 2025

Could Cancer Drugs Be the Future of Alzheimer’s Treatment?

NBC News—Gladstone Investigator Yadong Huang comments on a new study he helped lead, in which two cancer drugs showed signs of slowing or reversing symptoms of Alzheimer’s disease.

Gladstone Experts Alzheimer’s Disease Huang Lab

Article July 21, 2025

Inside the Brain: Tackling Neurological Disease at Its Roots

For World Brain Day, discover some of Gladstone’s latest breakthroughs in neurological research.

Gladstone Experts Research (Publication) Alzheimer’s Disease COVID-19 Parkinson’s Disease Neurological Disease Akassoglou Lab Corces Lab Huang Lab Mucke Lab

Article July 21, 2025

Combination of Two Cancer Drugs May Work Against Alzheimer’s

A new study has identified FDA-approved cancer drugs that reverse the gene expression signatures associated with Alzheimer’s.

News Release Research (Publication) Alzheimer’s Disease Neurological Disease Huang Lab

Gladstone in the News April 16, 2025

The Unusual Genetic Inheritance That Could Change Alzheimer’s Treatment

Nature—In the 1980s, scientists began studying a family that suffered a genetic form of early-onset Alzheimer’s disease. Three decades later, they identified one member of that family who showed remarkable protection against the cognitive decline of Alzheimer’s due to a rare mutation in the ApoE gene. Now, Gladstone Senior Investigator Yadong Huang and others are working to develop therapies that mimic that protective mutation, hoping to treat or even prevent Alzheimer’s disease.

Gladstone Experts Alzheimer’s Disease Huang Lab

Gladstone in the News November 18, 2024

Brain Cells Boost Damage Caused by Alzheimer’s Risk Variant

Labroots—Gladstone scientist Yadong Huang comments on his recent study that shows how microglia and APOE4 interact to promote important aspects of Alzheimer’s disease.

Gladstone Experts Alzheimer’s Disease Neurological Disease Huang Lab

Article November 4, 2024

Brain Immune Cells Amplify Damage Caused by Alzheimer’s Risk Gene, Study Finds

Transplanting human neurons into mouse brains reveals disease-causing interactions between the APOE4 protein and immune cells.

News Release Research (Publication) Alzheimer’s Disease Neurological Disease Huang Lab

Article September 25, 2024

Gladstone Presents Inaugural Sobrato Prize in Neuroscience to Yadong Huang, a Pioneer of Alzheimer’s Research

The prize will be awarded annually to a Gladstone scientist who has made breakthrough discoveries in brain research; funds will help advance scientific discoveries from the lab to the clinic.

Awards News Release Alzheimer’s Disease Neurological Disease Huang Lab Aging Human Genetics

Article September 16, 2024

Meet Gladstone: Misha Zilberter

Misha Zilberter discusses his Alzheimer’s disease research, the importance of collaboration in science, and the advice he has for young scientists

Profile Alzheimer’s Disease Neurological Disease Huang Lab

Gladstone in the News June 19, 2024

Rare Gene Mutation Helps People Resist Alzheimer’s Disease

Washington Post—Gladstone Senior Investigator Yadong Huang offers commentary on a new study examining the protective power of the rare “Christchurch” gene variant against Alzheimer’s. (Subscription required)

Alzheimer’s Disease Huang Lab

Gladstone in the News December 11, 2023

How CRISPR Gene Editing Could Help Treat Alzheimer’s

Nature—Recent work by Gladstone Senior Investigator Yadong Huang and his team on the APOE4 Christchurch mutation is featured in a review of the potential for CRISPR to revert mutations that cause Alzheimer’s disease.

Gladstone Experts Alzheimer’s Disease Neurological Disease Huang Lab CRISPR/Gene Editing

Article November 13, 2023

How Good Can Overpower Evil in the Genetic Determination of Alzheimer’s Disease

New research sheds light on protective mechanisms of the “Christchurch mutation”

News Release Research (Publication) Alzheimer’s Disease Center for Translational Advancement Neurological Disease Huang Lab

Article October 20, 2023

Study on Largest Genetic Risk Factor for Alzheimer’s Points Toward New Drug Target

Gladstone researchers discovered how the ApoE4 gene variant makes neurons release an inflammatory signaling molecule—and how blocking that release could prevent or treat Alzheimer’s disease

News Release Research (Publication) Alzheimer’s Disease Neurological Disease Huang Lab

Article September 27, 2023

When Two Disruptive Technologies Converge

How gene editing and stem cells are working in tandem at Gladstone Institutes to change science and medicine

Deep Dive Stem Cells/iPSCs CRISPR/Gene Editing Srivastava Lab Yamanaka Lab Doudna Lab Conklin Lab Marson Lab Huang Lab Ott Lab

Article May 16, 2023

Meet Gladstone: Seo Yeon Yoon

Seo Yeon Yoon, a research scientist in the Huang lab, shares her passion for puzzles and why AAPI Heritage Month is important to her.

Profile Huang Lab