The research goal of Alex Marson’s lab is to understand the genetic circuits that control the function of cells in the human immune system, especially T cells. Marson and colleagues have developed new tools to accomplish efficient genome engineering in primary human immune cells with CRISPR. With this technology scientists can now readily rewrite specific sequences in human cells and interrogate the biological effects. These advances in genome editing will accelerate fundamental insights into how immune cells are “wired” and have potential to enhance the next generation of cell- based immunotherapies for cancer, infectious diseases, organ transplantation, and autoimmune diseases.

Disease Areas

Autoimmune Diseases
Cancer Immunotherapies
HIV/AIDS
Infectious Diseases
Inflammation

Areas of Expertise

CRISPR Genome Engineering
Functional Genomics
Human Genetics
Immunology
Immunotherapy Design
CAR T Cells
Working in the Marson lab

Lab Focus

Developing new tools for efficient genome engineering and forward genetic studies in primary human immune cells.
Pursuing a comprehensive strategy to test how coding and non-coding DNA sequences control functional programs in the immune system.
Engineering immunotherapies that tune immune cell function to treat cancer, autoimmune diseases, inflammation, and infections.
Performing functional genetic studies of host-pathogen interactions in primary human immune cells.

Research Impact

Marson’s team is pioneering new CRISPR gene-editing technologies that offer faster, cheaper and more precise ways to re-write DNA programs in human immune cells. With these tools, the lab is engineering cells to treat a wide range of diseases. They are designing programs to make cells that can recognize and eliminate cancer, cells that are resistant to infections like HIV, and cells that can reduce inflammation in autoimmune diseases like multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. Reprogrammed human immune cells are emerging as a new class of “living” medicines.

 

Lab Members

Dylan Aidlen
Graduate Student
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Niran Almudhfar, MS
Research Associate III
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Maya Arce, PhD
Graduate Student
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James Asaki
Graduate Student
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Sagar Bapat, MD, PhD
Affiliate
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Franziska Blaeschke, MD
Collaborator
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Daniel Carr
Collaborator
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Ananya Choudhury
Student Intern
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Emma Dann, PhD
Visiting Postdoc
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Pascal Devant, PhD
Postdoctoral Scholar
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Stacie Dodgson, PhD
Scientific Program and Strategy Manager
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Eli Dugan
Graduate Student
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Xinyi Feng
Research Associate I
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Emilio Ferrara
Rotation Student
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Jacob Freimer, PhD
Collaborator
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Daniel Goodman
Affiliate
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Laine Goudy
Graduate Student
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Reese Guitche
Student Intern
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Yomn Hammad
Student Intern
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Rosmely Hernandez, PhD
Scientist
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Kamir Hiam, PhD
Visiting Scientist
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Hyuncheol Jung, PhD
Visiting Postdoc
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Idan Kashani
Student Intern
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Shanshan Lang, PhD
Senior Staff Research Scientist
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Caleb Lareau, PhD
Visiting Scientist
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Matthew Lau
Student Intern
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Benjamin Lesch
Graduate Student
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Zhongmei Li, MS
Affiliate
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Qi Liu, PhD
Visiting Postdoc
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Murad Mamedov, PhD
Scientist
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Ron Manlapaz
Research Scientist
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Donna Marsh
Research Associate II
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Kristen Mengwasser, MD, PhD
Clinical Fellow
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Yasaman Mortazavi, MS
Research Associate III
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Carson Moseley, MD, PhD
Clinical Fellow
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Cody Mowery
Visiting Scientist
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Ruchita Nair, MS
Research Associate II
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Catherine Novick
Research Associate I
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Mineto Ohta, MD, PhD
Visiting Postdoc
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Ujjwal Rathore, PhD
Staff Research Scientist III
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Justine Reyes Retana Lopez
Research Associate I
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Ralf Schmidt, MD
Collaborator
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Jin Seo
Research Associate I
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Eric Shifrut, PhD
Collaborator
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Keshav Sridharan
Student Intern
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Zachary Steinhart, PhD
Staff Research Scientist I
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Robert Stickels, PhD
Visiting Scientist
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Sanjana Subramanya, MS
Research Associate II
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Hunter Thornton
Research Associate III
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Carinna Tran
Research Associate I
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Jenny Umhoefer, PhD
Postdoctoral Scholar
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Jon Woo
Affiliate
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Galen Xing, PhD
Graduate Student
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Tori Yamamoto, PhD
Scientist
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Jun Yan, PhD
Postdoctoral Scholar
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Emma Yin, MD
Visiting Scientist
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Shimin Zhang
Research Associate I
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Ronghui Zhu, PhD
Postdoctoral Scholar
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Zijian Zhu
Rotation Student
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