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New Approach to CRISPR Delivery Opens the Door to Editing Multiple Genes Safely

Gladstone in the News April 25, 2023

New Approach to CRISPR Delivery Opens the Door to Editing Multiple Genes Safely

Innovative Genomics Institute—Work from Alex Marson, director of the Gladstone-UCSF Institute of Genomic Immunology, and Affiliate Investigator Justin Eyquem demonstrates a new, more efficient and gentle method to introduce CRISPR editing machinery into cells.

Gladstone Experts Genomic Immunology Eyquem Lab Marson Lab CRISPR/Gene Editing

The Race to Supercharge Cancer-Fighting T Cells

Gladstone in the News January 26, 2023

The Race to Supercharge Cancer-Fighting T Cells

Nature—Alex Marson, MD, PhD, director of the Gladstone-UCSF Institute of Genomic Immunology, and his colleagues have been using CRISPR to increase the therapeutic potential of T cells. This work is part of a worldwide effort to improve the design and manufacturing of cancer-killing ‟CAR-T” cells reviewed in the journal Nature.

Gladstone Experts Cancer Genomic Immunology Marson Lab CRISPR/Gene Editing

Parker Institute Extends ‘Crazy Idea’ Funding to Two More Cancer Centers

Gladstone in the News December 23, 2022

Parker Institute Extends ‘Crazy Idea’ Funding to Two More Cancer Centers

STAT News—The Parker Institute for Cancer Immunotherapy has expanded to include a new center at Gladstone Institutes. Center Director Alex Marson says the funding will enable Gladstone scientists to take on bold, high-risk ideas and create better cell therapies for cancer.

Institutional News Cancer Genomic Immunology Marson Lab

Obesity May Alter Inflammation on a Molecular Level, Throwing Current Treatments into Question

Gladstone in the News April 6, 2022

Obesity May Alter Inflammation on a Molecular Level, Throwing Current Treatments into Question

Fierce Biotech—Alexander Marson, director of the Gladstone-UCSF Institute of Genomic Immunology, and his colleagues at UC San Francisco and the Salk Institute for Biological Studies, recently showed that obese mice with atopic dermatitis had an altered immune response that made them refractory to anti-inflammatory treatment. Fierce Biotech discusses the implications of this finding for the development of drugs against inflammation and asthma.

Gladstone Experts Genomic Immunology Marson Lab Disease Models

Obesity Can Turn a Helpful Immunotherapy into a Harmful One, Mouse Study Shows

Gladstone in the News March 30, 2022

Obesity Can Turn a Helpful Immunotherapy into a Harmful One, Mouse Study Shows

STAT News—Alexander Marson, director of the Gladstone-UCSF Institute of Genomic Immunology, describes new research from his group showing that the immune response in a mouse model of atopic dermatitis is altered by obesity. This difference rendered first-line therapies ineffective in mice, indicating that treatments for inflammatory disorders may need to be tailored to work in individual patients, depending on their metabolic state.

Gladstone Experts Genomic Immunology Marson Lab Disease Models Metabolism

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