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January 6, 2013

Unique Protein Interaction May Drive Most Common Genetic Cause of Parkinson’s Disease

San Francisco, CA—The most devastating aspect of Parkinson’s disease may not be its debilitating symptoms, which rob its victims of their ability to control their own movement. It may not be the millions around the world and their families who suffer each day from the disease’s harmful effects.

Finkbeiner Lab

December 19, 2012

Gladstone Scientists Identify Powerful Infection Strategy of Widespread and Potentially Lethal Virus

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have mapped the molecular mechanism by which a virus known as cytomegalovirus (CMV) so successfully infects its hosts.

Weinberger Lab

December 5, 2012

Gladstone Scientists Discover Novel Mechanism by Which Calorie Restriction Influences Longevity

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have identified a novel mechanism by which a type of low-carb, low-calorie diet—called a “ketogenic diet”—could delay the effects of aging.

Aging

December 4, 2012

Gladstone Scientists: “ApoE Is an Ideal Target for Halting Progression of Alzheimer’s Disease”

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes are recommending a shift in efforts to treat Alzheimer’s disease by developing drugs that target the apoE4 protein, which has long been associated with an increased risk for the disease.

Alzheimer’s Disease Huang Lab Mahley Lab

December 3, 2012

ALS Therapy Development Institute and Gladstone Institutes Collaborate to Discover Potential ALS Treatments

CAMBRIDGE, MA and SAN FRANCISCO, CA—The ALS Therapy Development Institute (ALS TDI) and the Gladstone Institutes today announced the formation of a research collaboration to speed the discovery of potential treatments for ALS through the preclinical drug development process.

ALS Finkbeiner Lab

November 26, 2012

Gladstone Scientists Identify Key Biological Mechanism in Multiple Sclerosis

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have defined for the first time a key underlying process implicated in multiple sclerosis (MS)—a disease that causes progressive and irreversible damage to nerve cells in the brain and spinal cord.

Akassoglou Lab Multiple Sclerosis

October 28, 2012

Gladstone President to Receive Prestigious Pacesetter Award

SAN FRANCISCO, CA—Gladstone President R. Sanders "Sandy" Williams, MD, will receive the ARCS Foundation’s 2012 Pacesetter Award next week for his lifelong dedication to furthering education and his extensive contributions to science and medicine.

October 27, 2012

Gladstone, Stanford Scientists Collaborate to Block Toxic Protein that Plays Key Role in Lou Gehrig’s Disease

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes and the Stanford University School of Medicine have discovered how modifying a gene halts the toxic buildup of a protein found in nerve cells. These findings point to a potential new tactic for treating a variety of neurodegenerative conditions, including amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease)—a fatal disease for which there is no cure.

ALS

October 7, 2012

Gladstone Scientists Discover Gene “Bursting” Plays Key Role in Protein Production

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have mapped the precise frequency by which genes get turned on across the human genome, providing new insight into the most fundamental of cellular processes—and revealing new clues as to what happens when this process goes awry.

Basic Science Weinberger Lab

October 7, 2012

Gladstone Scientists Identify Biological Mechanism that Plays Key Role in Early-Onset Dementia

SAN FRANCISCO, CA—Using animal models, scientists at the Gladstone Institutes have discovered how a protein deficiency may be linked to frontotemporal dementia (FTD)—a form of early-onset dementia that is similar to Alzheimer’s disease.

October 7, 2012

Gladstone Scientist Wins Nobel Prize in Medicine

Shinya Yamanaka MD, PhD, a senior investigator at the Gladstone Institutes has won the 2012 Nobel Prize in Physiology or Medicine for his discovery of how to transform ordinary adult skin cells into cells that, like embryonic stem cells, are capable of developing into any cell in the human body.

Stem Cells/iPSCs Yamanaka Lab Stem Cells/iPSCs

September 12, 2012

Gladstone Scientists Map the Genomic Blueprint of the Heart

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have revealed the precise order and timing of hundreds of genetic “switches” required to construct a fully functional heart from embryonic heart cells—providing new clues into the genetic basis for some forms of congenital heart disease.

Bruneau Lab

September 11, 2012

Gladstone-Led Study Underscores Truvada’s Potency in Preventing the Transmission of HIV

SAN FRANCISCO, CA—New research from an international team of HIV/AIDS experts has reaffirmed the effectiveness of Truvada—the first and only medication approved by the FDA for HIV prevention.

Grant Lab HIV/AIDS

September 10, 2012

Gladstone Scientists Develop Innovative Technique to Monitor and Decipher the Dormant AIDS Virus Concealed in Cells

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have gotten us one step closer to understanding and overcoming one of the least-understood mechanisms of HIV infection—by devising a method to precisely track the life cycle of individual cells infected with HIV, the virus that causes AIDS.

HIV/AIDS Weinberger Lab

August 5, 2012

Gladstone Scientists Discover that Epilepsy Drug Reverses Memory Loss in Animal Model of Alzheimer’s Disease

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have discovered that an FDA-approved anti-epileptic drug reverses memory loss and alleviates other Alzheimer’s-related impairments in an animal model of the disease.

Alzheimer’s Disease Epilepsy Mucke Lab

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Congrats to Jennifer Doudna, winner of the 2020 Nobel Prize in Chemistry!