Stem cells that have the potential to develop into any type of cell in the body are called pluripotent. Pluripotent stem cells arise naturally in the early stages of embryonic development. Induced pluripotent stem (iPS) cells are adult cells that have been reprogrammed to take on the properties of embryonic cells.

Research at Gladstone Institutes

Scientists at Gladstone use iPS cells to better understand, prevent, treat, and cure some of the world’s most devastating diseases.

Gladstone strategically built a diverse community of scientific and clinical experts whose mission is to make groundbreaking scientific discoveries and bring these advances to the clinic. With expertise in stem cell biology, medicine, chemistry, and engineering, Gladstone is uniquely positioned to tackle complex problems from various angles with a highly collaborative, team-based approach.

The Roddenberry Stem Cell Center is an international powerhouse in stem cell research. Established in 2011 with a gift from the Roddenberry Foundation in honor of Eugene Roddenberry, the creator of Star Trek, the center operates with a vision of disrupting basic and translational stem cell science.

The Roddenberry Stem Cell Center provides resources for the Gladstone community to pursue new biomedical discoveries and conduct the rigorous testing needed to translate their most promising findings to the clinic. IPS cells provide unparalleled insight into genetic diseases, empower personalized medicine, and may someday be used to generate tissues and organs for transplantation. The efforts of the Roddenberry Stem Cell Center help Gladstone scientists unlock this tremendous potential of stem cells to advance human health and transform the treatment of disease.

Scientific Areas of Focus

  • Induced pluripotent stem cells
  • Direct cellular reprogramming
  • Reprogramming through chemical biology
  • Modeling human disease
  • Tissue engineering 

Disease Applications

Amyotrophic lateral sclerosis (ALS)

Alzheimer’s disease

Cardiovascular disease

Diabetes

Huntington’s disease

Liver failure

Macular degeneration

Parkinson’s disease

Spinal cord injury

Core Members

Benoit Bruneau

Bruce Conklin

Sheng Ding

Steve Finkbeiner

Warner Greene

Yadong Huang

Todd McDevitt

Lennart Mucke

Ken Nakamura

Jeanne Paz

Seth Shipman

Deepak Srivastava

Shinya Yamanaka

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