Steven Finkbeiner and his lab study how brain cells learn and remember, and what causes them to malfunction and die in disease. The long-term goal is to understand how neuronal activity leads to learning and memory. Memory defects occur in several neurological and psychiatric diseases, and the lab has developed animal or cell-based models of several of them, including Huntington’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), frontotemporal dementia, Alzheimer’s disease, autism and schizophrenia. The group has also developed state-of-the-art technologies to generate and analyze large troves of images and genetic data, including robotic microscopy and artificial intelligence.

Disease Areas

Huntington’s Disease
Parkinson’s Disease
Amyotrophic Lateral Sclerosis (ALS)
Frontotemporal Dementia
Alzheimer’s Disease
Autism
Schizophrenia
Neurodegenerative Diseases

Areas of Expertise

Stem Cells and iPS Cells
Disease Models
Robotic Microscopy
Artificial Intelligence
Human Genetics
Genetic and Small Molecule Screening
FinkbeinerLabFocus2.jpg

Lab Focus

Understanding the basic mechanisms by which cells mitigate stresses such as the protein misfolding involved in aging and disease.
Finding causes and treatments for Huntington’s, Parkinson’s and Alzheimer’s disease, ALS, frontotemporal dementia and schizophrenia.
Inventing and developing innovative technologies such as robotics and artificial intelligence to accelerate the pace of science and the discovery of cures.

Research Impact

Finkbeiner’s lab strives to understand the neurobiology of disease well enough to design rational interventions and produce effective treatments. They bring human biology into the lab by combining human genomics and the creation of human models of disease based on iPS cells and other patient material. The limitations of conventional approaches led them to invent new tools such as robotic microscopy, and to adapt artificial intelligence to unravel cause and effect in complex mechanisms and gain insights from data that elude comprehension by the unaided human brain.

The work has led to seminal findings for the field and promising new therapeutic approaches. In one instance, robotic microscopy helped resolve a decade-old controversy about the pathogenesis of Huntington’s disease. In another, new biosensor technology helped design neuroprotective compounds that cause cells to destroy disease-causing proteins linked to Alzheimer’s, Parkinson’s and Huntington’s disease.

 

Professional Titles

Senior Investigator, Gladstone Institutes

Director, Center for Systems and Therapeutics, Gladstone Institutes

Director, Taube/Koret Center for Neurodegenerative Disease Research, Gladstone Institutes

Director, Hellman Family Foundation Alzheimer’s Disease Research Program, Gladstone Institutes

Investigator, Roddenberry Stem Cell Center, Gladstone Institutes

Professor, Neurology and Physiology, UC San Francisco

Bio

Steve Finkbeiner, MD, PhD, is director of the Center for Systems and Therapeutics and a senior investigator at Gladstone Institutes. In 2009, with support from Bay Area philanthropists, he established the Taube/Koret Center for Neurodegenerative Disease Research at Gladstone to accelerate the development of drug therapies for patients suffering from conditions such as Huntington’s disease. Finkbeiner is also director of the Hellman Family Foundation Alzheimer’s Disease Research Program and an investigator in the Roddenberry Stem Cell Center at Gladstone. In addition, he is a professor of neurology and physiology at UC San Francisco (UCSF).

Finkbeiner earned a bachelor’s degree from Wheaton College, and earned both an MD and a PhD in neuroscience from Yale University. He completed an internship in internal medicine and chief residency in neurology at UCSF, followed by a research fellowship at Harvard Medical School.

Finkbeiner is an associate editor of the journal Autophagy and serves on the editorial board of the Journal of Huntington’s Disease and BioMed Central. He has received numerous awards for his work and is a member of several scientific and professional societies, including the American Neurological Association, the Society for Neuroscience, the Society for Cell Biology, and the Biophysical Society.

His expertise encompasses neurodegenerative and psychiatric diseases, iPS cell modeling, human genetics, robotics, imaging, computational methods and artificial intelligence. He is known for inventing robotic microscopy, a platform for performing high-throughput longitudinal single-cell analysis, and for a series of discoveries about the biology of disease made with this approach.

How Did You Get Your Start in Science?

“I fell in love with engineering playing with Lego, and my 8th grade science teacher took an interest in me, spurring my interests in science and medicine.”

Steve Finkbeiner, MD, PhD

Honors and Awards

2017 National Institutes of Neurological Disorders and Stroke Award for Outstanding and Innovative Contributions to Neurological Disease Research

2017 Commitment to a Cure Award, ALS Association Golden West Chapter

2011 Award for Outstanding Research Achievement, Nature Biotechnology

2008 Annual Outstanding Faculty Mentorship Award, Graduate Student Association, UC San Francisco

2008 Distinguished Leadership Award, Huntington’s Disease Society of America

2010 Thomson Reuters - The most cited primary research paper in Neuroscience and Behavior for the preceding 10-year period

2005 Therapeutics Initiative Award, Huntington’s Disease Society of America

2005 Taube Prize for Outstanding Work on Huntington’s Disease

2005 Lieberman Award for Outstanding Work in Huntington’s Disease

2001 W.M. Keck Research Excellence Award

2001 Klingenstein Award in Neuroscience

1999 Charles E. Culpepper Medical Scholar Award

Publications

See More

Contact

Steve Finkbeiner

415.734.2508

Kelley Nelson
Senior Executive Assistant

415.734.2509


Lab Members

Amela Alijagic
Research Assistant
Naufa Amirani
Research Engineer I
Lise Barbe, PhD
Postdoctoral Scholar
Mariya Barch, PhD
Bioinfo Software Engineer III
Selim Boudoukha, PhD
Senior Research Associate
Nicholas Castello, PhD
Senior Research Associate
Michelle Chan
Research Associate II
Melanie Cobb, PhD
Staff Research Scientist I
Sina Dabiri, MS
Research Engineer II
Leandro De Araujo Lima, PhD
Bioinformatician II
Minnie Deng
Research Associate I
Lisa Elia, PhD
Scientific Program Leader I
Irina Epstein, PhD
Visiting Scientist
Zohreh Faghihmonzavi, MS
Research Associate II
Stellar Hope
Student Intern (Unpaid)
Rajshri Iyer
Research Associate II
Cody Jackson
Research Engineer I
Ashkan Javaherian, PhD
Scientific Program Leader II
Jaslin Kalra, MS
Visiting Researcher
Julia Kaye, PhD
Scientific Program Leader II
Julie Lai
Student Intern
Stephanie Lam
Research Engineer I
Josh Lamstein, MS
Research Engineer II
Jen Leddy, MS
Senior Research Associate
Pinky Lee
Research Associate I
Sara Modan
Research Associate II
Viral Oza, MS
Research Associate II
Chris Paiz
Research Associate II
Cathrine Petersen
Rotation Student
Keili Prenton
Student Intern
Claire Quinata
Lab Assistant
Krishna Raja
Research Associate I
Krithikka Ravi, MS
Research Associate III
Reem Shammet
Student Intern
Zachary Tokuno
Research Associate I
Giabao Tonthat
Student Intern
Edward Vertudes, MS
Research Associate II
Hui Wang
Research Associate III
Stacia Wyman, PhD
Visiting Scientist