Jeanne Paz’s lab aims to improve the outcome for patients with stroke, brain injuries, and epilepsy by studying these disorders in animal models and identifying potential targets for new therapeutic interventions. A signature approach in her lab is optogenetics, which allows her team to disrupt the function of specific brain cells in live animals. Using this approach, the group identified a brain region called the thalamus as a choke point for various forms of epilepsy—and a promising target for future therapies. Current research includes the role of the immune system in regulating neural circuit function and understanding how to boost the brain’s ability to recover after injury to prevent debilitating consequences such as epilepsy and neurocognitive deficits.
Areas of Expertise
Paz’s team showed they could stop epileptic seizures in mice in real time and with no side effects using optogenetics to control specific brain cells known as thalamocortical neurons. This work identified thalamocortical neurons as potential targets in the development of effective therapies against post-stroke seizures.
Optogenetics could also be used to identify the cells and circuits responsible for other forms of epilepsy or for neurological and cognitive disorders, leading to targeted therapeutics against these diseases as well.
Recent work by the team shows a link between chronic brain inflammation and the development of post-injury epilepsy, suggesting that certain anti-inflammatory drugs could be used in the treatment of this form of epilepsy.
Associate Investigator, Gladstone Institute of Neurological Disease
Associate Professor, Department of Neurology, UC San Francisco
Jeanne Paz is an associate investigator at Gladstone Institutes. She is also an associate professor of neurology in the Kavli Institute for Fundamental Neuroscience at UC San Francisco.
Before joining Gladstone, Paz completed a postdoctoral fellowship at Stanford University, where she identified seizure control points in the brain. Paz earned her undergraduate and graduate degrees from Université Pierre et Marie Curie in Paris. As a graduate student, she studied the role of basal ganglia in regulating absence epilepsy and received an award for the best neuroscience PhD thesis in France.
How Did You Get Your Start in Science?
“I always wondered: if we knew how the brain works, would we be able to understand ourselves?”
Honors and Awards
2022 Neuroscience Program Executive Committee, UCSF
2022 Diversity Champion Award, Gladstone Institutes
2021 Outstanding Mentor Award, Gladstone Institutes
2020 Co-Chair Neuroscience Formal Seminar Series Committee, UCSF
2019 Vilcek Prize for Creative Promise, Vilcek Foundation
2019 Associate Editor, Progress in Neurobiology
2017 Top reviewer 2 years in a row, Nature Publishing Group
2015 Michael Prize (Best Epilepsy Research), International League Against Epilepsy
2013 Challenge Award, Citizens United for Research in Epilepsy
2012 K99 Pathway to Independence Career Award, National Institutes of Health
2009 American Epilepsy Foundation Fellowship
2008 Best PhD in Neuroscience award in France (Prix de Thèse), French Society for Neuroscience
2007 Linus Pauling Graduate, University Pierre and Marie Curie
2005 Award for the best poster presentation in Neuroscience, 7ème Colloque de la Société des Neurosciences Française, French Society for Neuroscience
2003 Graduate Research Fellowship, French Ministry of Research and Technology
2002 Merit Scholarship, French Science Foundation, University Pierre and Marie Curie