Jeanne Paz’s lab aims to improve the outcome for patients with epilepsy by studying the disorder in animal models and identifying potential targets for new therapeutic interventions. A signature approach in her lab is optogenetics, which allows her team to disrupt the function of specific brain cells in live animals. Using this approach, the group identified a small brain region called the thalamus as a choke point for various forms of epilepsy—and a promising target for future therapies. Current research includes understanding how the thalamus controls seizures in distant brain regions, and how brain lesions like stroke and trauma can lead to epilepsy.

Disease Areas

Epilepsy
Traumatic Brain Injury
Stroke
Dravet Syndrome
Autism
Alzheimer’s Disease

Areas of Expertise

Optogenetics
Electrophysiology (in vitro and in vivo)
Electroencephalography
Seizure Prediction
Miniature Brain Microscopes
PazClemente.jpg

Lab Focus

Understanding how neurons synchronize their activity in normal brains, and the cause of the excessive synchrony that is the hallmark of epileptic episodes.
Understanding the anatomical and physiological changes that allow the development of epilepsy after stroke and trauma, and in neurodegenerative disease.
Identifying biomarkers of epileptogenesis as a means of anticipating or preventing epileptic episodes.

Research Impact

Paz’s team showed they could stop epileptic seizures in mice in real time and with no side effects using optogenetics to control specific brain cells known as thalamocortical neurons. This work identified thalamocortical neurons as potential targets in the development of effective therapies against post-stroke seizures.

Optogenetics could also be used to identify the cells and circuits responsible for other forms of epilepsy or for neurological and cognitive disorders, leading to targeted therapeutics against these diseases as well.

Recent work by the team shows a link between chronic brain inflammation and the development of post-injury epilepsy, suggesting that certain anti-inflammatory drugs could be used in the treatment of this form of epilepsy.

 

Professional Titles

Associate Investigator, Gladstone Institutes

Associate Professor of Neurology, UC San Francisco

Bio

Jeanne Paz is an associate investigator at the Gladstone Institutes. She is also an associate professor of neurology in the Kavli Institute for Fundamental Neuroscience at UC San Francisco.

Before joining Gladstone, Paz completed a postdoctoral fellowship at Stanford University, where she identified seizure control points in the brain. Paz earned her undergraduate and graduate degrees from the University Pierre et Marie Curie in Paris. As a graduate student, she studied the role of basal ganglia in regulating absence epilepsy and received an award for the best neuroscience PhD thesis in France.

How Did You Get Your Start in Science?

“I always wondered: if we knew how the brain works, would we be able to understand ourselves?”

Jeanne Paz, PhD

Honors and Awards

2019 Vilcek Prize for Creative Promise, Vilcek Foundation

2019 Associate Editor, Progress in Neurobiology

2015 Michael Prize (Best Epilepsy Research), International League Against Epilepsy

2013 Challenge Award, Citizens United for Research in Epilepsy

2012 K99 Pathway to Independence Career Award, National Institutes of Health

2009 American Epilepsy Foundation Fellowship

2008 Best PhD in Neuroscience award in France (Prix de Thèse), French Society for Neuroscience

2007 Linus Pauling Graduate, University Pierre and Marie Curie

2005 Award for the best poster presentation in Neuroscience, 7ème Colloque de la Société des Neurosciences Française, French Society for Neuroscience

2003 Graduate Research Fellowship, French Ministry of Research and Technology

2002 Merit Scholarship, French Science Foundation, University Pierre and Marie Curie

2017 Top reviewer 2 years in a row, Nature Publishing Group

Publications

See More

Contact

Jeanne Paz

415.734.2515

Stephanie Tuazon
Administrative Assistant II

415.734.2531


Lab Members

Marie Burkart
Rotation Student
Andrew Chang, PhD
Postdoctoral Scholar
Frances Cho
Graduate Student
Agnieszka Ciesielska, PhD
Postdoctoral Scholar
Bryan Higashikubo, PhD
Visiting Scientist
Stephanie Holden
Graduate Student
Morgane Leroux
Visiting Researcher
Irene Lew
Research Associate II
Zuha Warraich, PhD
Visiting Scientist