Todd McDevitt’s research focuses on engineering technologies to direct the differentiation and organization of stem cells to create functional tissues. His team is creating models of human tissues that can be used to study embryonic development and develop new approaches to treat diseases that afflict the cardiovascular, neurological, and immunological systems. McDevitt’s group was the first to show they could create a new type of spinal cord neuron from human pluripotent stem cells that might be useful to treat spinal cord injuries. They are now examining the therapeutic potential of these cells in animal models and developing novel organoid models of the central nervous system.

Disease Areas

Congenital Heart Disease
Spinal Cord Injury
Heart Failure
Neurodegenerative Diseases
Immune Diseases

Areas of Expertise

Aging
Stem Cells and iPS Cells
Organoids
Disease Models
Tissue Engineering
Biomaterials
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Lab Focus

Discovering critical mechanisms that regulate differentiation and morphogenesis of pluripotent cells during tissue development.
Creating functional 3D models of human tissues—such as heart, hindbrain, and spinal cord,—from pluripotent stem cells.
Investigating the ability of stem-cell secreted factors to rejuvenate aged cells and tissues.

Research Impact

Human tissue constructs and organoids derived from stem cells offer novel model systems for probing mechanisms of embryonic development. In addition, engineered human microtissues provide valuable biological substrates to interrogate infectious and genetic diseases and the effects of exposure to other environmental factors.

McDevitt's lab uses a bottom-up approach to understand how cells cooperatively interact to form complex tissues and dictate multicellular organization and subsequent physiologic function. They have developed systems to achieve spatiotemporal control of morphogen presentation from biomaterials incorporated within 3D environments of stem cell aggregates, and established 3D computational models of stem cell differentiation and morphogenesis. More recently, they have also used CRISPR-based technologies to engineer multicellular organization of stem cells in a self-directed manner. The group has a long-standing interest in harnessing the potency of molecules produced by pluripotent stem cells in different manners for regenerative and rejuvenative applications.

 

Professional Titles

Senior Investigator, Gladstone Institutes

Professor of Bioengineering and Therapeutic Sciences, UC San Francisco

Program Director, Graduate Program in Bioengineering, UC San Francisco and UC Berkeley

Bio

Todd C. McDevitt is a senior investigator at Gladstone Institutes. He is also a professor of bioengineering and therapeutic sciences at UC San Francisco, as well as the program director for the joint Graduate Program in Bioengineering at UC San Francisco and UC Berkeley.

McDevitt graduated with a bachelor’s degree in biomedical and electrical engineering from Duke University. He earned a PhD in bioengineering from the University of Washington, where he worked on methods to engineer cardiac and skeletal muscle tissue. He then completed a postdoctoral fellowship in the Department of Pathology at the University of Washington, in which he studied signaling pathways that affect the proliferation of cardiomyocytes derived from pluripotent stem cells. He has received several awards, including a New Investigator Award from the American Heart Association and a Young Investigator Award from the Society for Biomaterials, and was inducted into the American Institute of Medical and Biological Engineering (AIMBE) College of Fellows in 2014.

McDevitt's lab integrates fundamental principles of cell and tissue engineering, biomaterials, and systems approaches with stem cell and development biology expertise to determine how to create functional models of human tissues for regenerative medicine therapies and enable new biological discoveries. Their long-term goal is to create robust models of complex human biological systems that can faithfully recapitulate dynamic morphogenic processes and facilitate the translation of biomedical therapies for congenital, degenerative and infectious human diseases.

How Did You Get Your Start in Science?

“My initial interest in science was sparked by my AP Chemistry teacher, Lee Marek, in high school.”

Todd McDevitt, PhD

Honors and Awards

2014 CIRM Research Leadership Award, California Institute for Regenerative Medicine

2014 Elected to American Institute of Medical and Biological Engineering (AIMBE) College of Fellows

2014 Top Medical Researcher, Atlanta Business Chronicle

2013 “40 Under 40,” Georgia Trend magazine

2013 Best Advisor Award, Georgia Tech Bioengineering Graduate Program

2013 Carol Ann and David D. Flanagan Professorship, Georgia Tech

2013 Best of BIOT (invited webinar), American Chemical Society

2011 “Above and Beyond” (Eagle) Award, Georgia Tech Biomedical Engineering Society

2011 Most Influential Georgians (Notables), Georgia Trend Magazine

2011 UK-US Collaboration Development Award

2010 Most Influential Georgians (Notables), Georgia Trend Magazine

2010 Young Investigator Award, Society for Biomaterials

2010 Junior Faculty Outstanding Undergraduate Research Mentor Award, Georgia Tech

2009 Petit Institute Interdisciplinary Research and Education Award, Georgia Tech

2009 Petit Faculty Fellow, Institute for Bioengineering and Bioscience, Georgia Tech

2008 UK-US Stem Cell Collaboration Development Award

2004 New Investigator Award, American Heart Association, Council on Basic Cardiovascular Sciences

Publications

See More

Contact

Todd McDevitt

415.734.2875

Sue Cammack
Senior Administrative Assistant

415.734.2713


Lab Members

Emily Bulger
Graduate Student
Jessie Butts, PhD
Visiting Postdoc
Sue Cammack
Senior Administrative Assistant
Beulah Dadala
Student Intern
Ana De Andrade E Silva, PhD
Postdoctoral Scholar
Nick Elder
Graduate Student
Will Flanigan
Rotation Student
Eliza Gaylord
Rotation Student
Tracy Hookway, PhD
Visiting Scientist
David Joy
Graduate Student
Serah Kang, PhD
Postdoctoral Scholar
Ariel Kauss
Graduate Student
Jasmine King
Graduate Student
Marty Krakora
Research Associate I
Ashley Libby
Visiting Scientist
Ron Manlapaz
Senior Research Associate
Oriane Matthys
Graduate Student
Dylan McCreedy, PhD
Visiting Postdoc
Vaishaali Natarajan, PhD
Postdoctoral Scholar
Sarah Rockwood
Research Associate I
Diwakar Turaga, MD, PhD
Visiting Scientist
Ivana Vasic
Graduate Student
Lana Zholudeva, PhD
Postdoctoral Scholar