Gladstone’s Melanie Ott and Alex Marson Elected to the National Academy of Medicine
Physician-scientists and directors at Gladstone Institutes, Ott and Marson are honored for their pioneering achievements in science and medicine.
Behavioral
Through collaborative interactions and consultations, the Behavioral Core serves researchers at Gladstone, UC San Francisco, other nonprofit research institutions, and for-profit entities.
Together with colleagues in clinical programs, we are investigating the relation between impairments in patients with brain disorders and in rodent models simulating these conditions. These studies aim to promote the development of suitable tests and novel treatment strategies to improve cognition and other neural functions in patients suffering from devastating diseases of the nervous system.
Fees & Scheduling
As a part of Gladstone, an independent nonprofit entity, the Behavioral Core offers prices that are lower than market and compare favorably with other service providers in the Bay Area. Recharge rates are based on the cost of services rendered.
For more information, contact Jeff Simms.
Scheduling
Projects are scheduled through iLab. Contact Jeff Simms to register for iLab.
Once a project is submitted, the core management team will schedule the desired assessments.
Our Process
Initiate Project
- Selection of tests to validate specific hypotheses based on careful review of the pertinent literature and the core database.
- Behavioral test battery customized according to specific experimental or therapeutic interventions and mouse models.
Behavioral Testing
- Battery of 60+ behavioral tests covering diverse behavioral domains including sensorimotor functions, emotional and social behaviors, and cognitive functions such as learning and memory.
- State-of-the-art equipment not typically seen in individual labs.
- Experienced personnel ensures conclusive design and reliable execution of experiments.
Data Analysis and Publication
- Rigorous statistical analyses and expert interpretation of data.
- Presentation-ready data package delivered on completion of project.
- Assistance with manuscript and report preparation.
Services Provided
We offer nearly 70 different assessments covering diverse behavioral domains, including sensorimotor functions, emotional and social behaviors, and cognitive functions such as learning and memory.
- Chronic Intermittent Stress
- Elevated Plus Maze
- Forced Swim Test
- Light/Dark Box
- Novelty-Suppressed Feeding
- Restraint Stress
- Social Defeat Stress
- Sucrose Preference
- Tail Suspension
- Barnes Maze
- Conditioned Place Aversion
- Conditioned Place Preference
- Contextual Fear Conditioning
- Cued Fear Conditioning
- Five Choice Serial Reaction Time
- Hole Board Task
- Interactive Place Avoidance
- Morris Water Maze
- Novel Arm Recognition
- Novel Object Recognition
- Novel Place Recognition
- Object/Context Congruence
- Olfactory Discrimination
- Operant/Instrumental Conditioning
- Operant Self Administration
- Pattern Separation
- Paired Associates Learning
- Passive/Active Avoidance
- Pavlovian Conditioned Approach
- Repeated Open Field Activity
- Response Learning
- Spontaneous Alternation
- Visual Discrimination
- Water Cross Maze
- Burrowing
- Developmental Milestones
- Marble Burying
- Nesting
- Self-Grooming
- Ultrasonic Vocalization
- Balance Beam
- Climbing Cylinder
- Forced Exercise
- Gait Analysis
- Grip Strength
- Hot Plate
- Inverted Grid Hang
- Olfactory Habituation
- Open Field Activity
- Pole Test
- Rotarod
- Running Wheels (Wireless/Manual)
- Startle/Prepulse Inhibition
- Tail Flick
- Visual Cliff
- Direct Social Interaction
- Emotional Contagion
- Resident Intruder
- Mating Behavior
- Pup Retrieval
- Social Approach
- Social Memory
- Social Novelty
- Social Recognition
- Transmission of Food Preference
- Seizure Thresholds
- Custom Designs
FAQs
Yes. The earlier we can meet with our users, the better. We find that when we’re involved in the early planning stages, we can help design studies that produce more robust and reproducible outcomes.
Projects can be initiated through iLab. Contact Jeff Simms to register for iLab and receive detailed instruction on project submission.
The core provides a complete service package, including data compilation and analysis. The data package is designed to be ready for publication and we provide support throughout the publication process.
We often work with researchers to adapt existing protocols or create novel paradigms to best answer individual research questions. These are often the most exciting and interesting projects for our team.
Publications
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Neurons require glucose uptake and glycolysis in vivo.
Li H, Guglielmetti C, Sei YJ, et al. (2023) Cell Reports. Apr 6;42(4):112335. doi: 10.1016/j.celrep.2023.112335.
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Enhancing GAT-3 in thalamic astrocytes promotes resilience to brain injury in rodents.
Cho FS, Vainchtein ID, Voskobiynyk Y, et al. (2022) Sci Transl Med. Jul 6;14(652):eabj4310. doi: 10.1126/scitranslmed.abj4310.
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Kv1.1 preserves the neural stem cell pool and facilitates neuron maturation during adult hippocampal neurogenesis.
Lin King YH, Chen C, Lin King JV, et al. (2022) PNAS. May 31;119(22):e2118240119. doi: 10.1073/pnas.2118240119.
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Mouse midbrain dopaminergic neurons survive loss of the PD-associated mitochondrial protein CHCHD2.
Nguyen MK, McAvoy K, Liao SC, et al. (2022) Hum Mol Genet. May 4;31(9):1500-1518. doi: 10.1093/hmg/ddab329.
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TAU ablation in excitatory neurons and postnatal TAU knockdown reduce epilepsy, SUDEP, and autism behaviors in a Dravet syndrome model.
Shao E, Chang CW, Li Z et al. (2022) Sci Transl Med. Apr 27, 14(642) doi: 10.1126/scitranslmed.abm5527
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