The research goal of Alex Marson’s lab is to understand the genetic circuits that control the function of cells in the human immune system, especially T cells.
Marson and colleagues have developed new tools to accomplish efficient genome engineering in primary human immune cells with CRISPR. With this technology scientists can now readily rewrite specific sequences in human cells and interrogate the biological effects. These advances in genome editing will accelerate fundamental insights into how immune cells are “wired” and have potential to enhance the next generation of cell- based immunotherapies for cancer, infectious diseases, organ transplantation, and autoimmune diseases.
Disease Areas
- Autoimmune Diseases
- Cancer
- HIV/AIDS
- Infectious Diseases
- Inflammation
Areas of Expertise
- CRISPR Genome Engineering
- Functional Genomics
- Human Genetics
- Immunology
- Immunotherapy Design
- CAR T Cells
Lab Focus
- Developing new tools for efficient genome engineering and forward genetic studies in primary human immune cells.
- Pursuing a comprehensive strategy to test how coding and non-coding DNA sequences control functional programs in the immune system.
- Engineering immunotherapies that tune immune cell function to treat cancer, autoimmune diseases, inflammation, and infections.
- Performing functional genetic studies of host-pathogen interactions in primary human immune cells.
Research Impact
Marson’s team is pioneering new CRISPR gene-editing technologies that offer faster, cheaper and more precise ways to re-write DNA programs in human immune cells. With these tools, the lab is engineering cells to treat a wide range of diseases. They are designing programs to make cells that can recognize and eliminate cancer, cells that are resistant to infections like HIV, and cells that can reduce inflammation in autoimmune diseases like multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. Reprogrammed human immune cells are emerging as a new class of “living” medicines.