Gladstone Scientific Advisory Board

George Q. Daley is an internationally recognized leader in stem cell science and cancer biology and a long-time faculty member of Harvard Medical School. He has testified before Congress and spoken in forums worldwide on the scientific and ethical dimensions of stem cell research and its promise in treating disease.

Daley’s research uses mouse and human disease models to identify mechanisms that underlie blood disorders and cancer, and aims to understand how stem cells contribute to tissue regeneration and repair. Daley’s earlier work on the BCR/ABL protein in chronic myelogenous leukemia provided critical support for the development of the highly successful chemotherapeutic agent Gleevec (imatinib).

Daley is an elected member of the National Academy of Medicine.

Joe Goldstein and his colleague, Michael S. Brown, have been recognized with many awards for their work on cholesterol, including the Lasker Award in Basic Medical Research (1985), Nobel Prize in Physiology or Medicine (1985), and National Medal of Science (1988). Their discovery of the low-density lipoprotein (LDL) helped lay the groundwork for the development of statins, drugs that lower cholesterol in the blood and prevent heart attacks.

Goldstein is currently chair of the Albert Lasker Medical Research Awards Jury and is a member of the Boards of Trustees of the Howard Hughes Medical Institute and The Rockefeller University. He is also a member of the National Academy of Sciences, National Academy of Medicine, and a Foreign Member of the Royal Society.

Eric Olson and his trainees discovered many of the genes that control heart and muscle formation and disease. These discoveries have revealed fundamental principles of tissue formation and provided new concepts in the quest for treatments for muscle and cardiovascular diseases. Among his accomplishments, Olson has provided a new strategy for correcting Duchenne muscular dystrophy with CRISPR technology.

Olson has co-founded multiple biotechnology companies to develop therapies for heart and muscle disease, including Myogen, Miragen, Tenaya Therapeutics, and Exonics. He is also a member of the National Academy of Sciences, the National Academy of Medicine, and the American Academy of Arts and Sciences.

Charles Rice co-discovered the hepatitis C virus (HCV), for which he shared the 2020 Nobel Prize in Physiology or Medicine. He also produced the first infectious molecular clone of the virus, and established cell culture systems and animal models for studying HCV replication and evaluating antivirals.

Rice is an elected member of the National Academy of Sciences and the National Academy of Medicine and is a fellow of the American Association for the Advancement of Science. He is a past president of the American Society for Virology.

Arlene Sharpe and her laboratory team discovered the immunoinhibitory functions of the CTLA-4 and PD-1 pathways, which have become exceptionally promising targets for cancer immunotherapy. Sharpe’s research currently focuses on translating fundamental understanding of T cell costimulation into new therapies for autoimmune diseases and cancer.

Sharpe is an elected member of the National Academy of Sciences, National Academy of Medicine, National Academy of Inventors, and the American Academy of Arts and Sciences. She is also a member and past president of the American Association of Immunologists.

Li-Huei Tsai’s laboratory takes a multidisciplinary approach to elucidate the molecular, cellular, and circuit basis of neurological disorders—especially Alzheimer’s—that impact learning and memory. She and her team have created numerous applications of iPS cells for in vitro modeling of neurological diseases.

At MIT, Tsai is co-director of the Alana Down Syndrome Center and co-founder of the Aging Brain Initiative. She was previously a faculty member in the Department of Pathology at Harvard Medical School and a Howard Hughes Medical Institute Investigator. Tsai is a member of the National Academy of Medicine, the National Academy of Inventors, and the American Association for the Advancement of Science.