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Why Immunotherapy Still Holds So Much Potential

Gladstone in the News November 21, 2024

Why Immunotherapy Still Holds So Much Potential

Drug Discovery World—Alex Marson, director of the Gladstone-UCSF Institute of Genomic Immunology, is featured for his innovative work using CRISPR genome editing to develop better cellular therapies for cancer, silencing genes that cause immune cells to become exhausted and activating genes that help them be more effective.

Gladstone Experts Cancer Genomic Immunology Marson Lab CRISPR/Gene Editing

CRISPR-Based Mapping Uncovers ‘Switches’ for Immune Genes Central to Health

Marson Lab
Article May 29, 2024

CRISPR-Based Mapping Uncovers ‘Switches’ for Immune Genes Central to Health

A new study in Nature Genetics expands our understanding of immune regulation and autoimmunity—with findings that could also be used in the development of cancer immunotherapies.

News Release Autoimmune Diseases Cancer Genomic Immunology Parker Institute for Cancer Immunotherapy Marson Lab Pollard Lab Ye Lab AI CRISPR/Gene Editing

Advancing CRISPR Applications: Here, There and Everywhere

Gladstone in the News January 16, 2024

Advancing CRISPR Applications: Here, There and Everywhere

BioTechniques—Researchers at Gladstone Institutes have mapped the human immune response using next-generation CRISPR technology known as base editing. Using this tool, the team was able to identify specific nucleotides within T cells that influence immune cells’ response to stimuli, creating maps of DNA sequences and protein sites that are involved in human immune responses. The discoveries this project has facilitated could improve existing immunotherapies and reveal new drug targets for autoimmune diseases and cancer.

Research (Publication) Autoimmune Diseases Cancer Genomic Immunology Doudna Lab Marson Lab CRISPR/Gene Editing Genomics

Using Next-Gen CRISPR Tool, Gladstone Scientists Create Unprecedented Molecular Map of Human Immune Response

Carl Ward, a Gladstone postdoctoral associate, speaks with a student intern in the Marson Lab.
Article December 13, 2023

Using Next-Gen CRISPR Tool, Gladstone Scientists Create Unprecedented Molecular Map of Human Immune Response

The new study from the Marson Lab represents a major stride for human genetics; findings will accelerate the development of new and better therapies for cancer and autoimmune diseases.

News Release Research (Publication) Autoimmune Diseases Cancer Genomic Immunology Marson Lab Basic Science CRISPR/Gene Editing Genomics Human Genetics

CRISPR Cures for Cancer: Partnership to Accelerate Cell Therapy Using Genomics

Gladstone in the News September 18, 2023

CRISPR Cures for Cancer: Partnership to Accelerate Cell Therapy Using Genomics

UCSF News—Gladstone Senior Investigators Alex Marson and Jennifer Doudna, and President of the UC San Francisco Helen Diller Family Comprehensive Cancer Center Alan Ashworth, will head the newly launched CRISPR Cures for Cancer Initiative, which will fund research at the intersection of genomic technologies and cellular immunotherapies at Gladstone Institutes, UC San Francisco, and the Innovative Genomics Institute at UC Berkeley.

Gladstone Experts Cancer Data Science and Biotechnology Genomic Immunology Doudna Lab Marson Lab CRISPR/Gene Editing Stem Cells/iPSCs

New Approach to CRISPR Delivery Opens the Door to Editing Multiple Genes Safely

Gladstone in the News April 25, 2023

New Approach to CRISPR Delivery Opens the Door to Editing Multiple Genes Safely

Innovative Genomics Institute—Work from Alex Marson, director of the Gladstone-UCSF Institute of Genomic Immunology, and Affiliate Investigator Justin Eyquem demonstrates a new, more efficient and gentle method to introduce CRISPR editing machinery into cells.

Gladstone Experts Genomic Immunology Eyquem Lab Marson Lab CRISPR/Gene Editing

The Race to Supercharge Cancer-Fighting T Cells

Gladstone in the News January 26, 2023

The Race to Supercharge Cancer-Fighting T Cells

Nature—Alex Marson, MD, PhD, director of the Gladstone-UCSF Institute of Genomic Immunology, and his colleagues have been using CRISPR to increase the therapeutic potential of T cells. This work is part of a worldwide effort to improve the design and manufacturing of cancer-killing ‟CAR-T” cells reviewed in the journal Nature.

Gladstone Experts Cancer Genomic Immunology Marson Lab CRISPR/Gene Editing

Parker Institute Extends ‘Crazy Idea’ Funding to Two More Cancer Centers

Gladstone in the News December 23, 2022

Parker Institute Extends ‘Crazy Idea’ Funding to Two More Cancer Centers

STAT News—The Parker Institute for Cancer Immunotherapy has expanded to include a new center at Gladstone Institutes. Center Director Alex Marson says the funding will enable Gladstone scientists to take on bold, high-risk ideas and create better cell therapies for cancer.

Institutional News Cancer Genomic Immunology Marson Lab

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