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Scientists Leverage Machine Learning to Decode Gene Regulation in the Developing Human Brain

scientists at Gladstone Institutes and University of California, San Francisco
Article May 24, 2024

Scientists Leverage Machine Learning to Decode Gene Regulation in the Developing Human Brain

A team of researchers from Gladstone Institutes and UC San Francisco combined high-throughput experiments and machine learning to analyze more than 100,000 sequences in human brain cells.

News Release Research (Publication) Data Science and Biotechnology Pollard Lab AI Big Data Developmental Biology Disease Models Genomics Human Genetics

Gladstone to Expand Stem Cell Research Capabilities with Multi-Million Dollar Regenerative Medicine Grant

Sam Hu prepares induced pluripotent stem cells.
Article March 11, 2024

Gladstone to Expand Stem Cell Research Capabilities with Multi-Million Dollar Regenerative Medicine Grant

Funds from the California Institute for Regenerative Medicine will allow Gladstone to bolster its disease-modeling technologies, add robust CRISPR screening capabilities, and educate young researchers on the latest in stem cell science.

Grants Assay Development and Drug Discovery Core Bioinformatics Core Stem Cell Core CRISPR/Gene Editing Disease Models Organoids Regenerative Medicine Stem Cells/iPSCs

Obesity May Alter Inflammation on a Molecular Level, Throwing Current Treatments into Question

Gladstone in the News April 6, 2022

Obesity May Alter Inflammation on a Molecular Level, Throwing Current Treatments into Question

Fierce Biotech—Alexander Marson, director of the Gladstone-UCSF Institute of Genomic Immunology, and his colleagues at UC San Francisco and the Salk Institute for Biological Studies, recently showed that obese mice with atopic dermatitis had an altered immune response that made them refractory to anti-inflammatory treatment. Fierce Biotech discusses the implications of this finding for the development of drugs against inflammation and asthma.

Gladstone Experts Genomic Immunology Marson Lab Disease Models

Obesity Can Turn a Helpful Immunotherapy into a Harmful One, Mouse Study Shows

Gladstone in the News March 30, 2022

Obesity Can Turn a Helpful Immunotherapy into a Harmful One, Mouse Study Shows

STAT News—Alexander Marson, director of the Gladstone-UCSF Institute of Genomic Immunology, describes new research from his group showing that the immune response in a mouse model of atopic dermatitis is altered by obesity. This difference rendered first-line therapies ineffective in mice, indicating that treatments for inflammatory disorders may need to be tailored to work in individual patients, depending on their metabolic state.

Gladstone Experts Genomic Immunology Marson Lab Disease Models Metabolism

“The Heart and Human Development” Featuring Dr. Benoit Bruneau

Gladstone in the News June 29, 2020

“The Heart and Human Development” Featuring Dr. Benoit Bruneau

The Stem Cell Podcast—Senior Investigator Benoit Bruneau describes his lab's recent work, including their use of stem cells to model and and understand congenital heart diseases, their investigation of the role of epigenetics in human development, and their sequencing of the Komodo dragon's genome, as well as his motivation and his path to science.

Gladstone Experts Congenital Heart Disease Cardiovascular Disease Bruneau Lab Disease Models Genomics Human Genetics Regenerative Medicine

A ‘Cure for Heart Disease’? A Single Shot Succeeds in Monkeys

Gladstone in the News June 27, 2020

A ‘Cure for Heart Disease’? A Single Shot Succeeds in Monkeys

The New York Times—Gladstone President Deepak Srivastava, MD, and Senior Investigator Jennifer Doudna, PhD, comment on a recent report of the successful use of novel CRISPR technology to lower cholesterol and triglyceride levels in monkeys.

Gladstone Experts Heart Failure Cardiovascular Disease Data Science and Biotechnology Doudna Lab Srivastava Lab CRISPR/Gene Editing Disease Models

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