News

Gladstone in the News August 1, 2026

A Single Faulty Gene Copy Can Unravel the Heart’s DNA

SciTech Daily—Scientists in the labs of Benoit Bruneau, Katie Pollard, and Deepak Srivastava uncovered a mechanism showing how small reductions in protein levels can disrupt DNA’s three-dimensional structure and lead to disease.

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Article July 23, 2026

Misfolded DNA Blueprint: A New Origin for Genetic Disease

Gladstone researchers found losing just one copy a particular gene can disrupt heart development and lead to congenital heart disease.

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Gladstone in the News January 23, 2026

The People Behind the Papers—Irfan Kathiriya and Benoit Bruneau

Development—Gladstone scientists Irfan Kathiriya and Benoit Bruneau comment on their study, which identified the gene TBX5 as a key regulator of the gene regulatory networks governing atrial cell type specification and a potential therapeutic target for genetic atrial diseases.

Gladstone Experts Congenital Heart Disease Cardiovascular Disease Bruneau Lab

Article January 23, 2026

Disrupted Boundary Between Cell Types Linked to Common Heart Defects

Gladstone scientists identified a cellular boundary that guides heart development and revealed how disrupting it can lead to holes in the heart’s wall.

News Release Research (Publication) Congenital Heart Disease Cardiovascular Disease Bruneau Lab

Article October 9, 2025

CIRM Awards $7.5 Million in Discovery Grants to Gladstone Investigators

Two ambitious research projects led by Gladstone investigators are boosted by funds from the California Institute for Regenerative Medicine.

Grants News Release Congenital Heart Disease Cardiovascular Disease Bruneau Lab Conklin Lab CRISPR/Gene Editing Human Genetics Regenerative Medicine

Article February 25, 2025

Matters of the Heart: A Conversation with Gladstone’s Benoit Bruneau

Bruneau, director of the Gladstone Institute of Cardiovascular Disease, shares exciting recent advances in heart research and talks about the impact of predictive AI.

Gladstone Experts Heart Failure Cardiovascular Disease Alexanian Lab Bruneau Lab Pollard Lab Theodoris Lab AI

Article December 14, 2023

Meet Gladstone: Emily Bulger

Graduate Student Emily Bulger describes her work in the Bruneau Lab, her family roots in science, and the scientist she'd like to have a conversation with

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Article February 2, 2023

“The Most Amazing Thing I’ve Ever Seen:” Heart Development Comes Alive

A Q&A with Gladstone Investigator Benoit Bruneau

Research (Publication) Congenital Heart Disease Cardiovascular Disease Bruneau Lab

Article January 26, 2022

Mutant Stem Cells Defy Rules of Development

Removing one gene from developing heart cells suddenly makes them turn into brain cell precursors, making researchers rethink cellular identity

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Video April 9, 2021

Devoted to Heart Development

Watch presentations from the Bruneau Lab 20th Anniversary Symposium held on March 19, 2021, via Zoom

Cardiovascular Disease Bruneau Lab

Article December 14, 2020

Study Reveals Networks of Genes Involved in Congenital Heart Disease

The findings could point toward new ways to prevent or treat one of the most common birth defects

News Release Research (Publication) Congenital Heart Disease Cardiovascular Disease Bruneau Lab Human Genetics Stem Cells/iPSCs

Article October 15, 2020

Gladstone Investigators Receive 4D Nucleome Award from the NIH

Benoit Bruneau and Katie Pollard study DNA folding to identify the genetic causes of congenital heart disease

Grants News Release Congenital Heart Disease Cardiovascular Disease Data Science and Biotechnology Bruneau Lab Pollard Lab

Gladstone in the News June 29, 2020

“The Heart and Human Development” Featuring Dr. Benoit Bruneau

The Stem Cell Podcast—Senior Investigator Benoit Bruneau describes his lab's recent work, including their use of stem cells to model and and understand congenital heart diseases, their investigation of the role of epigenetics in human development, and their sequencing of the Komodo dragon's genome, as well as his motivation and his path to science.

Gladstone Experts Congenital Heart Disease Cardiovascular Disease Bruneau Lab Disease Models Genomics Human Genetics Regenerative Medicine

Video May 1, 2020

How Do Our Genes Sculpt a Heart?

Watch the first video in the Newton Webinar Series and learn how genes sculpt our hearts.

Cardiovascular Disease Bruneau Lab

Article February 24, 2020

Tackling Heart Disease: It Takes a Team

Gladstone researchers are collaborating to solve cardiovascular diseases using new technologies.

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