On March 19, 2021, the Bruneau lab celebrated its 20-year anniversary with a 1-day virtual symposium. The symposium featured career panels and talks from current and former lab members from across the world.

Benoit Bruneau’s lab is broadly interested in understanding how genes are turned on and off during human development, and how this process is controlled during the formation of the heart in the embryo. Specifically, his team is investigating how errors in this process cause congenital heart disease. They use mouse models and human induced pluripotent stem cells to unravel the transcription factor networks that regulate sets of genes critical for heart development.

Watch the presentations from the symposium.

Opening Remarks

Benoit Bruneau, PhD
Director, Gladstone Institute of Cardiovascular Disease

Insulin-Producing Beta Cell Regeneration for Diabetes Remission

Heiko Leikert, PhD
Director, Helmholtz Munich

Epigenetic Control of Metabolism in Heart Failure

Paul Delgado-Olguín, PhD
Scientist, The Hospital for Sick Children

Coordinated Alternative Splicing and Alternative Polyadenylation

Pedro Miura, PhD
Assistant Professor, University of Nevada, Reno

Non-Academic Career Panel

Gain of KRAS Function in the Endothelium Is Sufficient to Cause Vascular Malformations That Require MEK But Not PI3K Signaling

Joshua Wythe, PhD
Associate Professor, Cardiovascular Research Institute, Baylor College of Medicine

Dissecting Specification of Cardiac Precursor Cells at the Single Cell Resolution

Alexis Krup
Graduate Student, Gladstone Institutes

Chromatin Remodeler Brahma Safeguards Canalization in Cardiac Mesoderm Differentiation

Swetansu Hota, PhD
Scientist, Gladstone Institutes

The Extracellular Matrix Protein Agrin Is Essential for Epicardial Epithelial-to-Mesenchymal Transition During Heart Development

Xin Sun, PhD
Researcher, Oxford University

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