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Obesity May Alter Inflammation on a Molecular Level, Throwing Current Treatments into Question

Gladstone in the News April 6, 2022

Obesity May Alter Inflammation on a Molecular Level, Throwing Current Treatments into Question

Fierce Biotech—Alexander Marson, director of the Gladstone-UCSF Institute of Genomic Immunology, and his colleagues at UC San Francisco and the Salk Institute for Biological Studies, recently showed that obese mice with atopic dermatitis had an altered immune response that made them refractory to anti-inflammatory treatment. Fierce Biotech discusses the implications of this finding for the development of drugs against inflammation and asthma.

Gladstone Experts Genomic Immunology Marson Lab Disease Models

Obesity Can Turn a Helpful Immunotherapy into a Harmful One, Mouse Study Shows

Gladstone in the News March 30, 2022

Obesity Can Turn a Helpful Immunotherapy into a Harmful One, Mouse Study Shows

STAT News—Alexander Marson, director of the Gladstone-UCSF Institute of Genomic Immunology, describes new research from his group showing that the immune response in a mouse model of atopic dermatitis is altered by obesity. This difference rendered first-line therapies ineffective in mice, indicating that treatments for inflammatory disorders may need to be tailored to work in individual patients, depending on their metabolic state.

Gladstone Experts Genomic Immunology Marson Lab Disease Models Metabolism

Immune System Gene Braking Discovery Opens Doors to New Cancer Therapies

Gladstone in the News October 1, 2020

Immune System Gene Braking Discovery Opens Doors to New Cancer Therapies

Genetic Engineering and Biotechnology News—Alex Marson, MD, PhD, director of the Gladstone-UCSF Institute of Genomic Immunology, explains the implications of his lab’s recent identification of gene networks that control the function of immune cells, known as regulatory T cells, for therapies against cancer and autoimmune diseases.

Gladstone Experts Autoimmune Diseases Genomic Immunology Marson Lab

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