News

Gladstone in the News December 11, 2023

How CRISPR Gene Editing Could Help Treat Alzheimer’s

Nature—Recent work by Gladstone Senior Investigator Yadong Huang and his team on the APOE4 Christchurch mutation is featured in a review of the potential for CRISPR to revert mutations that cause Alzheimer’s disease.

Gladstone Experts Alzheimer’s Disease Neurological Disease Huang Lab CRISPR/Gene Editing

Gladstone in the News November 28, 2023

Cancer Shredder Utilizes CRISPR, Targets Glioblastoma

Genetic Engineering & Biotechnology News—Scientists at the Gladstone Institutes have published a paper in Cell Reports that describes a CRISPR-based technique for treating primary glioblastoma, a common and aggressive form of brain cancer. The paper, titled “Targeting the non-coding genome and temozolomide signature enables CRISPR-mediated glioma oncolysis,” describes the technique, which the researchers have called “genome shredding.”

Research (Publication) Cancer Genomic Immunology Doudna Lab CRISPR/Gene Editing

Article November 27, 2023

CRISPR-Powered ‘Cancer Shredding’ Technique Opens New Possibility for Treating Most Common and Deadly Brain Cancer

Gladstone Institutes researchers leveraged CRISPR to target and rapidly destroy glioblastoma cells in an approach that could carry over to other highly mutated cancers

News Release Research (Publication) Cancer Doudna Lab CRISPR/Gene Editing

Gladstone in the News October 3, 2023

New Paper Points the Way to Make CRISPR Safer by Avoiding Chromosome Loss

Innovative Genomics Institute—Gladstone Senior Investigator Jennifer Doudna and Affiliate Investigator Jimmie Ye, along with collaborators at the Parker Institute for Cancer Immunology and Stanford, have discovered a way to increase the safety of CRISPR editing by preventing chromosome loss, a toxic side-effect of the technology in some cells.

Gladstone Experts Cancer Data Science and Biotechnology Parker Institute for Cancer Immunotherapy Doudna Lab Ye Lab CRISPR/Gene Editing

Article September 27, 2023

When Two Disruptive Technologies Converge

How gene editing and stem cells are working in tandem at Gladstone Institutes to change science and medicine

Deep Dive Stem Cells/iPSCs CRISPR/Gene Editing Srivastava Lab Yamanaka Lab Doudna Lab Conklin Lab Marson Lab Huang Lab Ott Lab

Gladstone in the News September 18, 2023

CRISPR Cures for Cancer: Partnership to Accelerate Cell Therapy Using Genomics

UCSF News—Gladstone Senior Investigators Alex Marson and Jennifer Doudna, and President of the UC San Francisco Helen Diller Family Comprehensive Cancer Center Alan Ashworth, will head the newly launched CRISPR Cures for Cancer Initiative, which will fund research at the intersection of genomic technologies and cellular immunotherapies at Gladstone Institutes, UC San Francisco, and the Innovative Genomics Institute at UC Berkeley.

Gladstone Experts Cancer Data Science and Biotechnology Genomic Immunology Doudna Lab Marson Lab CRISPR/Gene Editing Stem Cells/iPSCs

Article September 14, 2023

Lego-Like Gene Editing Tool Lets Researchers Improve Cancer Immunotherapy

Scientists used a new method to screen 10,000 combinations of gene edits in immune cells engineered to fight cancer

News Release Research (Publication) Cancer Genomic Immunology Marson Lab CRISPR/Gene Editing

Gladstone in the News June 30, 2023

The Audacious Pursuits of Jennifer Doudna

Nob Hill Gazette—Senior Investigator and Nobel Laureate Jennifer Doudna talks about CRISPR, its current and future clinical uses and their ethical implications, her life in science and a new direction for CRISPR called “The Audacious Project”.

Gladstone Experts Data Science and Biotechnology Doudna Lab CRISPR/Gene Editing

Gladstone in the News June 7, 2023

Podcast: The Impact of Genomics Is Closer Than You Think

CVS Health—Innovation in biomedical science is changing the way scientists think about the future of medicine. Gladstone President Deepak Srivastava describes how advances in genomics, gene editing, and cell programming may lead to new cures for human disease.

Gladstone Experts Congenital Heart Disease Cardiovascular Disease Srivastava Lab CRISPR/Gene Editing Human Genetics

Gladstone in the News April 25, 2023

New Approach to CRISPR Delivery Opens the Door to Editing Multiple Genes Safely

Innovative Genomics Institute—Work from Alex Marson, director of the Gladstone-UCSF Institute of Genomic Immunology, and Affiliate Investigator Justin Eyquem demonstrates a new, more efficient and gentle method to introduce CRISPR editing machinery into cells.

Gladstone Experts Genomic Immunology Eyquem Lab Marson Lab CRISPR/Gene Editing

Gladstone in the News April 20, 2023

A Brief but Spectacular Take on the Future of CRISPR

PBS News—Nobel Prize Laureate and Gladstone Senior Investigator Jennifer Doudna reflects on the responsible use of CRISPR, the genome editing tool she co-discovered.

Gladstone Experts Data Science and Biotechnology Doudna Lab CRISPR/Gene Editing

Article March 8, 2023

Researchers Discover How Too Much Oxygen Damages Cells and Tissues

High levels of oxygen can cause lasting health problems in humans. Now scientists know why.

News Release Research (Publication) Cardiovascular Disease Jain Lab CRISPR/Gene Editing

Gladstone in the News February 10, 2023

Filming a Movie Using CRISPR Technology

Science is Fun Podcast—Assistant Investigator Seth Shipman describes his remarkable technological advance repurposing CRISPR gene editing technology to record information inside living cells.

Gladstone Experts Data Science and Biotechnology Shipman Lab CRISPR/Gene Editing

Gladstone in the News January 26, 2023

The Race to Supercharge Cancer-Fighting T Cells

Nature—Alex Marson, MD, PhD, director of the Gladstone-UCSF Institute of Genomic Immunology, and his colleagues have been using CRISPR to increase the therapeutic potential of T cells. This work is part of a worldwide effort to improve the design and manufacturing of cancer-killing ‟CAR-T” cells reviewed in the journal Nature.

Gladstone Experts Cancer Genomic Immunology Marson Lab CRISPR/Gene Editing

Article December 7, 2022

Re-Engineering the Human Immune System

Researchers at the Gladstone-UCSF Institute of Genomic Immunology are learning how to harness the power of the human immune system in new ways

Gladstone Experts Cancer Genomic Immunology Carnevale Lab Doudna Lab Marson Lab Pelka Lab Roybal Lab Tang Lab Ye Lab