An mTOR-independent macroautophagy activator ameliorates tauopathy and prionopathy neurodegeneration phenotypes.
Yoon L, Botham RC, Verhelle A, Wu Y, Cole CM, Tan EP, Massey LA, Sanz-Martinez P, Chou C-C, Xu J, Elia LP, Lee K, Labra SR, Kline GM, Xiao Q, Rhoades D, Cano-Franco S, Cuoco CA, Ta A, Ren W, Hou WC, Wulkop-Gil C, Ibrahim LH, Nutsch K, Ko Y, Lederberg OL, Peng H, Jiang S, Lipton SA, Bollong MJ, Hansen M, Finkbeiner S, Finley D, Prado MA, Petrassi HM, Dikic I, Reggiori F, Garza D, Wiseman RL, Powers ET, Frydman J, Haggarty SJ, Johnson KA, Silva MC, Stolz A, Encalada SE, Kelly JW. bioRxiv [Preprint]. November 21, 2023.
A comprehensive enumeration of the human proteostasis network. 2. Components of the autophagy-lysosome pathway.
Elsasser S, Elia LP, Morimoto RI, Powers ET, Elsasser S, Finley D, Costa B, Budron M, Tokuno Z, Wang S, Iyer RG, Barth B, Mockler E, Finkbeiner S, Gestwicki JE, Richardson RAK, Stoeger T, Morimoto RI, Tan EP, Xiao Q, Cole CM, Massey LEA, Garza D, Powers ET, Kelly JW, Rainbolt TK, Chou CC, Masto VB, Frydman J, Nixon RA. bioRxiv [Preprint]. March 24, 2023.
Frontotemporal dementia patient neurons with progranulin deficiency display protein dyshomeostasis.
Elia L, Barth B, Alijagic A, Buselli C, Wong L, Morrison G, Prado M, Paulo JA, Gygi SP, Finley D, Finkbeiner S. bioRxiv [Preprint]. January 23, 2023.
Approaches to develop therapeutics to treat frontotemporal dementia.
Elia LP, Reisine T, Alijagic A, Finkbeiner S. Neuropharmacology. 2020 Apr; 166:107948.
Genetic regulation of neuronal progranulin reveals a critical role for the autophagy-lysosome pathway. Elia LP, Mason AR, Alijagic A, Finkbeiner S. J Neurosci. 2019 Apr 24;39(17):3332-3344.
The receptor-interacting serine/threonine protein kinase (RIPK1) regulates progranulin levels. Mason AR, Elia LP, Finkbeiner S. J Biol Chem. 2017 Feb 24;292(8):3262-3272
Progranulin protects against amyloid β deposition and toxicity in Alzheimer’s disease mouse models. Minami SS, Min SW, Krabbe G, Zhou Y, Asgarov R, Herl-Martens L, Elia LP, Ward M, Farese RV Jr., Gan L. Nat Med. 2014 Oct; 20(10):1157-64.
High-throughput RNA interference as a tool for discovery in neuroscience. Elia LP and Finkbeiner S. OMICs in Neurology and Neuroscience. Eds., Oxford University Press. 2012; Vol. pp. 114–131.
Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and β-catenin. Lee SH, Peng IF, Ng S, Yanagisawa M, Bamji SX, Elia L, Balsamo J, Lilien J, Anastasiadis PS, Ullian E, Reichardt LF. J Cell Biol. 2008 Dec 1; 183(5): 893–908.
p120 catenin regulates dendritic spine and synapse development through Rho-family GTPases and cadherins. Elia LP, Yamamoto M, Zang K, Reichardt LF. Neuron. 2006 Jul 6; 51(1): 43–56.
A role for a protease in morphogenic responses during yeast cell fusion. Elia L, Marsh L. J Cell Biol. 1998 Sep 21; 142(6): 1473–1485.
