CRISPR Cures for Cancer
Thursday, November 21, 2024

Join the second annual CRISPR Cures for Cancer Symposium, a one-day event bringing together investigators from the CRISPR Cures for Cancer network. This tri-institutional initiative is dedicated to accelerating the design and development of novel cell therapies for cancer using cutting-edge genomic technologies.

Throughout the symposium, researchers will present their most recent findings, showcasing innovative applications of CRISPR and other genomic tools in the fight against cancer. 

This year will also feature Nobel laureate Jennifer Doudna as a keynote speaker. Doudna, a pioneer in CRISPR technology, will share her insights on how genome editing will transform healthcare.

In addition to learning about the latest advancements, this symposium offers the space to foster collaborations and build connections with fellow scientists across institutions. Whether you’re an investigator, lab member, or collaborator, you’ll have the opportunity to share knowledge, spark new ideas, and drive future innovation in cancer research.

This event is open to researchers within the CRISPR Cures for Cancer initiative, their lab members, and members of Gladstone Institutes, UC San Francisco, and the Innovative Genomics Institute.

Program 

9:00am Welcome and Introduction
Alex Marson, MD, PhD | Gladstone Institutes, UC San Francisco
KEYNOTE ADDRESS
9:15am CRISPR Biology and Biotechnology: How Genome Editing Will Transform Healthcare 
Jennifer Doudna, PhD | Gladstone Institutes, UC Berkeley
10:15am Break
SESSION 1: FUNCTIONAL GENOMIC & PLATFORM DISCOVERY
10:30am High-Content Medium-Throughput Screening of Organoid Co-Cultures to Identify Novel Therapeutic Strategies for Colon Cancer
Jonathan Braverman, PhD | UC Berkeley
10:50am Dissecting Immune Hubs in Colon Cancer Using Spatial Profiling and Organoid-Based Models
Karin Pelka, PhD | Gladstone Institutes, UC San Francisco
11:10am In Vitro Cancer Models with Genome-Engineered Human Stem Cells at Scale
Hanqin Li, PhD | UC Berkeley
11:30am High-Throughput Genomics in Cancer Immunotherapy
Ansu Satpathy, MD, PhD | Gladstone Institutes, Stanford University
12:00pm Break
SESSION 2: PROJECT LIGHTNING TALKS
1:00pm EvolvR-Mediated Diversification of Targeted Genomic Loci in Primary T Cells
John Dueber, PhD | UC Berkeley
1:10pm Enhancing the Therapeutic Potential of Gene Edited Dendritic Cells and T Cells Through Functional Multiplexed Single Cell Analysis
Matthew Spitzer, PhD | Gladstone Institutes, UC San Francisco
1:20pm Targeting KRas G12C Mutant Cancers Using Inhibitor-Specific CAR T-Cells
Charles Craik, PhD | UC San Francisco
1:30pm Defining the Determinants of Response to Anti-BCMA CAR T Therapy in Multiple Myeloma
Kai Wu, PhD | UC San Francisco
1:40pm Systematic Design and Development of Engineered Macrophages with Enhanced Anti-Tumor Functions
Roarke Kamber, PhD | UC San Francisco
1:50pm In Vitro and In Silico Variant Functionalization
Jimmie Ye, PhD | Gladstone Institutes, UC San Francisco
SESSION 3: CELL THERAPY DEVELOPMENTS
2:00pm Home Grown Cell Therapies for Pancreatic Cancer
Greg Allen, MD, PhD | UC San Francisco
2:20pm Developing Cures for Cancer
Brian Shy, MD, PhD | Gladstone Institutes, UC San Francisco
2:40pm Break
SESSION 4: ENGINEERING CELL THERAPIES
3:20pm Gene Editing with Lipid Nanoparticle/mRNA Complexes
Niren Murthy, PhD | UC Berkeley
3:40pm Synthetic Receptors to Expand the Disease Sensing Ability of Engineered T Cells
Kole Roybal, PhD | Gladstone Institutes, UC San Francisco
4:00pm Leveraging Diverse Functional Screens in Human T Cells to Guide T Cell Therapy Engineering
Julia Carnevale, MD | Gladstone Institutes, UC San Francisco
4:20pm Improving T Cell Manufacturing via Enzyme Engineering and Streamlined Delivery
Ross Wilson, PhD | UC Berkeley
4:40pm In Vivo CRISPR Editing to Reprogram T Cell Function
Justin Eyquem, PhD | Gladstone Institutes, UC San Francisco
5:00pm Closing
Alan Ashworth, PhD, FRS | UC San Francisco
5:05pm Reception

CRISPR Cures for Cancer is a tri-institutional initiative to accelerate cell therapy design and development using genomic technologies. CRISPR Cures for Cancer unites researchers at UC San Francisco, Gladstone Institutes, and the Innovative Genomics Institute at UC Berkeley to accelerate the development of novel therapies for a wide variety of cancers by combining genetic discovery and design with innovations in CRISPR technology. 

Details

Dates
November 21, 2024
Time
9:00am-5:00pm PST
Location
Mahley Auditorium
Audience
Gladstone and UCSF, Scientific
Contact(s)







Diversity, Equity, and Inclusion

At Gladstone, we are committed to providing events and professional development activities that resonate with our community’s diverse members. Our goal is to develop creative programming that encompasses a wide variety of ideas and perspectives to inspire, educate, and engage with everyone within our walls.

We want to effect positive change through our events and activities by providing a platform for discussions on important topics related to increasing diversity and inclusiveness in the sciences.