News

Article December 11, 2024

Understanding How the Immune System Switches Between Rest and Action

Scientists at Gladstone and UCSF discover how one protein controls the behavior of immune cells, with potential applications for treating cancer and autoimmune conditions.

News Release Research (Publication) Autoimmune Diseases Cancer Genomic Immunology Krogan Lab Marson Lab CRISPR/Gene Editing

Article September 5, 2024

New Technology Could Lead to Alternative Treatments for Antibiotic-Resistant Bacteria

Scientists at Gladstone Institutes develop a streamlined and rapid way to engineer bacteria-fighting viruses known as phages

News Release Research (Publication) Data Science and Biotechnology Shipman Lab CRISPR/Gene Editing

Article August 26, 2024

3D Shapes of Viral Proteins Point to Previously Unknown Roles

Scientists uncover an ancient immune-evading strategy shared by animal viruses and viruses that infect bacteria; findings may help in the development of new antiviral therapies

News Release Research (Publication) Data Science and Biotechnology Virology Doudna Lab CRISPR/Gene Editing

Article July 9, 2024

New One-Step Method to Make Multiple Edits to a Cell’s Genome

Scientists at Gladstone develop a more efficient way to make several, precise edits simultaneously to human cells

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Gladstone in the News June 12, 2024

Podcast: ’The Voice Weekly’ Featuring Deepak Srivastava

The Voice of San Francisco—Gladstone President Deepak Srivastava, MD, talks about technologies driving the next wave of medicine, the importance of philanthropy dollars in fueling scientific breakthroughs, and how biotech is still breathing life into San Francisco's Mission Bay neighborhood.

Philanthropy Srivastava Lab Aging AI CRISPR/Gene Editing Stem Cells/iPSCs

Article May 29, 2024

CRISPR-Based Mapping Uncovers ‘Switches’ for Immune Genes Central to Health

A new study in Nature Genetics expands our understanding of immune regulation and autoimmunity—with findings that could also be used in the development of cancer immunotherapies.

News Release Autoimmune Diseases Cancer Genomic Immunology Parker Institute for Cancer Immunotherapy Marson Lab Pollard Lab Ye Lab AI CRISPR/Gene Editing

Article March 11, 2024

Gladstone to Expand Stem Cell Research Capabilities with Multi-Million Dollar Regenerative Medicine Grant

Funds from the California Institute for Regenerative Medicine will allow Gladstone to bolster its disease-modeling technologies, add robust CRISPR screening capabilities, and educate young researchers on the latest in stem cell science.

Grants Assay Development and Drug Discovery Core Bioinformatics Core Stem Cell Core CRISPR/Gene Editing Disease Models Organoids Regenerative Medicine Stem Cells/iPSCs

Article March 1, 2024

Vote for Gladstone in This Year’s ‘STAT Madness’ Tournament

The health and science publication STAT has selected a breakthrough discovery from Gladstone to be part of its annual STAT Madness competition, in which research institutes compete for the title of champion. The winner is deemed the most innovative research institution in the country.

Research (Publication) Cancer Genomic Immunology Doudna Lab CRISPR/Gene Editing

Gladstone in the News January 16, 2024

Advancing CRISPR Applications: Here, There and Everywhere

BioTechniques—Researchers at Gladstone Institutes have mapped the human immune response using next-generation CRISPR technology known as base editing. Using this tool, the team was able to identify specific nucleotides within T cells that influence immune cells’ response to stimuli, creating maps of DNA sequences and protein sites that are involved in human immune responses. The discoveries this project has facilitated could improve existing immunotherapies and reveal new drug targets for autoimmune diseases and cancer.

Research (Publication) Autoimmune Diseases Cancer Genomic Immunology Doudna Lab Marson Lab CRISPR/Gene Editing Genomics

Article January 11, 2024

Cellular Clean Energy: Can Mitochondria Make More Energy Without Collateral Damage?

New research from Gladstone may help in the development of new therapies that target the problem of cellular energy failure—a hallmark of Parkinson’s, Alzheimer’s, and aging in general

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Article December 13, 2023

Using Next-Gen CRISPR Tool, Gladstone Scientists Create Unprecedented Molecular Map of Human Immune Response

The new study from the Marson Lab represents a major stride for human genetics; findings will accelerate the development of new and better therapies for cancer and autoimmune diseases.

News Release Research (Publication) Autoimmune Diseases Cancer Genomic Immunology Marson Lab Basic Science CRISPR/Gene Editing Genomics Human Genetics

Gladstone in the News December 11, 2023

How CRISPR Gene Editing Could Help Treat Alzheimer’s

Nature—Recent work by Gladstone Senior Investigator Yadong Huang and his team on the APOE4 Christchurch mutation is featured in a review of the potential for CRISPR to revert mutations that cause Alzheimer's disease.

Gladstone Experts Alzheimer’s Disease Neurological Disease Huang Lab CRISPR/Gene Editing

Gladstone in the News November 28, 2023

Cancer Shredder Utilizes CRISPR, Targets Glioblastoma

Genetic Engineering & Biotechnology News—Scientists at the Gladstone Institutes have published a paper in Cell Reports that describes a CRISPR-based technique for treating primary glioblastoma, a common and aggressive form of brain cancer. The paper, titled “Targeting the non-coding genome and temozolomide signature enables CRISPR-mediated glioma oncolysis,” describes the technique, which the researchers have called “genome shredding.”

Research (Publication) Cancer Genomic Immunology Doudna Lab CRISPR/Gene Editing

Article November 27, 2023

CRISPR-Powered ‘Cancer Shredding’ Technique Opens New Possibility for Treating Most Common and Deadly Brain Cancer

Gladstone Institutes researchers leveraged CRISPR to target and rapidly destroy glioblastoma cells in an approach that could carry over to other highly mutated cancers

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Gladstone in the News October 3, 2023

New Paper Points the Way to Make CRISPR Safer by Avoiding Chromosome Loss

Innovative Genomics Institute—Gladstone Senior Investigator Jennifer Doudna and Affiliate Investigator Jimmie Ye, along with collaborators at the Parker Institute for Cancer Immunology and Stanford, have discovered a way to increase the safety of CRISPR editing by preventing chromosome loss, a toxic side-effect of the technology in some cells.

Gladstone Experts Cancer Data Science and Biotechnology Parker Institute for Cancer Immunotherapy Doudna Lab Ye Lab CRISPR/Gene Editing