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NIH Director’s Blog—Recent work from the team of Gladstone Associate Investigator Nadia Roan, PhD, and their colleagues at The Wistar Institute is featured in this week’s NIH Director’s Blog. The work uncovers intriguing evidence for the role of sugars at the surface of immune cells in HIV infection.
Gladstone Experts HIV/AIDS Virology Roan Lab
Gladstone scientists uncover novel aspects of HIV infection by monitoring sugars at the surface of individual immune cells
News Release Research (Publication) HIV/AIDS Virology Roan Lab
ABC7 News—As Omicron BA.4 and BA.5 variants overtake previous coronavirus variants across the United States, Gladstone Associate Investigator Nadia Roan, PhD, explains that their success may owe both to their ability to escape our immune system and to their accelerated replication rate. She suggests that more effort should be made to block infection at the level of the airways, the virus’s entry point into our body.
Gladstone Experts COVID-19 Roan Lab
San Francisco Chronicle—A study in the Mission District of San Francisco tracked how COVID-19 symptoms have changed over the course of the pandemic. Gladstone virologist Nadia Roan explains that the Omicron variant infects the upper respiratory tract and triggers a localized immune response, which may in part explain why individuals infected during the Omicron wave were less likely to experience severe illness.
Gladstone Experts COVID-19 Virology Roan Lab
ABC News—Gladstone virologists investigated the effect of the Omicron variant on the immune response. Melanie Ott describes her team’s discovery that previous infection with Omicron does not result in strong immunity to other known SARS-CoV-2 variants. However, as Nadia Roan explains, individuals who were vaccinated before becoming infected with Omicron did have a broadly protective immune response, emphasizing the importance of the vaccines in saving lives.
Gladstone Experts COVID-19 Virology Doudna Lab Greene Lab Ott Lab Roan Lab
Without vaccination, infection with Omicron fails to confer robust immunity against other COVID-19 variants
News Release Research (Publication) COVID-19 Virology Doudna Lab Ott Lab Roan Lab
And other questions you have about Omicron and the pandemic
Gladstone Experts COVID-19 Virology Greene Lab Ott Lab Roan Lab
Time—The Omicron variant of SARS-CoV-2 has spread around the world at an alarming rate, but some scientists think the variant might actually be a sign of hope. Nadia Roan explains that widespread infection may lead to widespread immunity, which could help turn the pandemic virus into an endemic virus. Warner Greene posits that the best-case scenario is that the virus will weaken, continuing to spread but without causing severe disease.
Gladstone Experts COVID-19 Virology Greene Lab Roan Lab
Gladstone virologists answer your most pressing questions about the latest variant of COVID-19
Gladstone Experts COVID-19 Virology Greene Lab Ott Lab Roan Lab
San Francisco Chronicle—The omicron variant of SARS-CoV-2 is spreading rapidly, but it may not be a reason for panic. Nadia Roan explains that our immune system’s cellular response to the vaccines should hold up well against the omicron variant. In addition, Warner Greene predicts that if the variant spreads rapidly but causes just mild disease, it might actually help establish immunity globally, protecting people in places where vaccine access has been limited.
Gladstone Experts COVID-19 Greene Lab Roan Lab
Researchers at Gladstone Institutes focus on innovative strategies that could finally allow people living with HIV to stop taking daily medications
Gladstone Experts HIV/AIDS Virology Greene Lab Ott Lab Roan Lab Weinberger Lab Deep Dive
San Francisco Chronicle—The emerging Omicron variant of SARS-CoV-2 features several mutations in its spike protein that in theory could make it resistant to current vaccines. But Associate Investigator Nadia Roan, PhD, explains that current vaccines will still protect against Omicron, as they elicit a variety of antibodies and immune T cells that target non-mutated areas of spike.
Gladstone Experts COVID-19 Virology Roan Lab
San Francisco Chronicle—Associate Investigator Nadia Roan, PhD, comments on a potentially new type of COVID-19 vaccine that would fight the virus at its points of entry—the nose, throat, or lungs—and may provide even better protection than current shots in the arm.
Gladstone Experts COVID-19 Virology Roan Lab
San Francisco Chronicle—Associate Investigator Nadia Roan, PhD, explains that people who receive COVID-19 vaccination after having had the disease harbor special immune cells that may provide stronger and more durable protection against future infections.
Gladstone Experts COVID-19 Virology Roan Lab
Gladstone researchers studied how T cells respond to COVID-19 vaccines over the weeks following immunization
News Release Research (Publication) COVID-19 Virology Roan Lab
