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Article March 9, 2016

Modified Form of CRISPR Acts as a Toggle Switch to Control Gene Expression in Stem Cells

Combining the two most powerful biological tools of the 21st century, scientists at the Gladstone Institutes have manipulated the genome of induced pluripotent stem cells for the first time using a variation of the CRISPR system.

Conklin Lab CRISPR/Gene Editing Stem Cells/iPSCs

Article July 14, 2015

Researchers Create Model of Early Human Heart Development from Stem Cells

The new system could serve as a drug-screening tool to make pregnancies safer.

Conklin Lab Stem Cells/iPSCs

Article July 9, 2015

A Land of Youth Transforms Stem Cell Biology

The discovery of cell reprogramming by Shinya Yamanaka changed the way scientists see cell biology, but the details of how it works are still being defined. In a recent paper, the labs of Yamanaka and Bruce Conklin show how one key factor—NANOG—is involved in the process.

Conklin Lab Yamanaka Lab Stem Cells/iPSCs