Gladstone in the News
January 18, 2024
STAT—New research has identified proteins present in the blood of people with long COVID that could point the way to a much-needed diagnostic test and possibly to future therapeutic targets. “The dysregulation they observed is a bit complex, as some complement components go up and others go down, but overall the results suggest that complement pathways are abnormal in people with long COVID,” said Gladstone's Nadia Roan, the senior author of a Nature Immunology paper published earlier in January on immune response in long COVID.
Gladstone Experts
COVID-19
Roan Lab
Gladstone in the News
January 16, 2024
BioTechniques—Researchers at Gladstone Institutes have mapped the human immune response using next-generation CRISPR technology known as base editing. Using this tool, the team was able to identify specific nucleotides within T cells that influence immune cells’ response to stimuli, creating maps of DNA sequences and protein sites that are involved in human immune responses. The discoveries this project has facilitated could improve existing immunotherapies and reveal new drug targets for autoimmune diseases and cancer.
Research (Publication)
Autoimmune Diseases
Cancer
Genomic Immunology
Doudna Lab
Marson Lab
CRISPR/Gene Editing
Genomics
Gladstone in the News
January 12, 2024
San Francisco Chronicle—At least 10 percent of those who survive COVID continue to face debilitating symptoms months after the acute infection resolves. New research from the laboratory of Gladstone Senior Investigator Nadia Roan shows that individuals suffering Long Covid have a dysregulated immune response to the virus and evidence of T cell exhaustion, which may be due to the virus persisting within their bodies.
Gladstone Experts
COVID-19
Virology
Roan Lab
Article
January 11, 2024
Scientists at Gladstone Institutes and UC San Francisco analyzed immune cells in people with and without long COVID, making significant discoveries that will help answer questions about what causes the condition and how to treat it
News Release
Research (Publication)
COVID-19
Virology
Roan Lab
Article
December 19, 2023
Highlights from 2023
History
Article
December 14, 2023
Graduate Student Emily Bulger describes her work in the Bruneau Lab, her family roots in science, and the scientist she'd like to have a conversation with
Profile
Bruneau Lab
Article
December 11, 2023
Melanie Ott, director of the Gladstone Institute of Virology, reflects on the breakthroughs driven by the COVID-19 pandemic and explains why virologists’ work is never done
Gladstone Experts
COVID-19
Virology
Ott Lab
Gladstone in the News
December 3, 2023
Genetic Engineering & Biotechnology News—In addition to genetic changes, environmental factors are associated with the development of birth defects. A new study led by Deepak Srivastava, president of Gladstone Institutes, reveals how maternal diabetes alters a small subset of cells in the developing heart in a way that can lead to congenital heart defects.
Gladstone Experts
Congenital Heart Disease
Diabetes
Cardiovascular Disease
Srivastava Lab
Single Cell
Gladstone in the News
November 28, 2023
Genetic Engineering & Biotechnology News—Scientists at the Gladstone Institutes have published a paper in Cell Reports that describes a CRISPR-based technique for treating primary glioblastoma, a common and aggressive form of brain cancer. The paper, titled “Targeting the non-coding genome and temozolomide signature enables CRISPR-mediated glioma oncolysis,” describes the technique, which the researchers have called “genome shredding.”
Research (Publication)
Cancer
Genomic Immunology
Doudna Lab
CRISPR/Gene Editing
