The Center for PhAIge Therapy combines engineering and artificial intelligence to leverage the potential of phages—viruses that naturally infect and kill bacteria—as new treatment options for these drug-resistant infections.
Despite promising results in individual patients, phage therapy has remained difficult to use at a larger scale. The new research center will build the preclinical tools and models needed to overcome this obstacle and make phages a more reliable treatment for infections.
Gladstone scientists have already built AI to predict which phages work against a given bacterial strain, but those models need far more data to be accurate. In this center, the researchers are generating an unprecedented amount of data to train the models by using engineered phages and bacteria to better understand, step by step, how bacteria are killed.