News

Article October 22, 2025

Scientists Pinpoint a Key Gene Behind Heart Defects in Down Syndrome

After decades of mystery, Gladstone researchers identify a gene that can derail heart formation—and show that fixing it prevents the problem in mice.

News Release Research (Publication) Congenital Heart Disease Cardiovascular Disease Pollard Lab Srivastava Lab AI CRISPR/Gene Editing Stem Cells/iPSCs

Article October 9, 2025

CIRM Awards $7.5 Million in Discovery Grants to Gladstone Investigators

Two ambitious research projects led by Gladstone investigators are boosted by funds from the California Institute for Regenerative Medicine.

Grants News Release Congenital Heart Disease Cardiovascular Disease Bruneau Lab Conklin Lab CRISPR/Gene Editing Human Genetics Regenerative Medicine

Article May 10, 2024

Gladstone’s Deepak Srivastava Honored as Most Admired CEO by San Francisco Business Times

The San Francisco Business Times has named Srivastava as one of the Most Admired CEOs among Bay Area businesses and nonprofits. The cardiologist and stem cell pioneer has served in the top leadership role at Gladstone Institutes since 2018.

Awards Institutional News News Release Congenital Heart Disease Cardiovascular Disease Srivastava Lab

Gladstone in the News December 3, 2023

Genetic Mechanisms Linking Maternal Diabetes and Birth Defects Uncovered

Genetic Engineering & Biotechnology News—In addition to genetic changes, environmental factors are associated with the development of birth defects. A new study led by Deepak Srivastava, president of Gladstone Institutes, reveals how maternal diabetes alters a small subset of cells in the developing heart in a way that can lead to congenital heart defects.

Gladstone Experts Congenital Heart Disease Diabetes Cardiovascular Disease Srivastava Lab Single Cell

Gladstone in the News November 7, 2023

Special Episode: JAHA Distinguished Hearts and Minds Roundtable

AHA with JAHA Podcast—In a roundtable forum, the American Heart Association’s 2023 Distinguished Scientists describe their contributions to stroke and cardiovascular research. Gladstone President Deepak Srivastava discusses the use of human iPS cells in drug discovery and his hopes for the future of science and medicine, including applications of artificial intelligence.

Gladstone Experts Congenital Heart Disease Cardiovascular Disease Srivastava Lab Human Genetics Stem Cells/iPSCs

Gladstone in the News June 7, 2023

Podcast: The Impact of Genomics Is Closer Than You Think

CVS Health—Innovation in biomedical science is changing the way scientists think about the future of medicine. Gladstone President Deepak Srivastava describes how advances in genomics, gene editing, and cell programming may lead to new cures for human disease.

Gladstone Experts Congenital Heart Disease Cardiovascular Disease Srivastava Lab CRISPR/Gene Editing Human Genetics

Article February 2, 2023

“The Most Amazing Thing I’ve Ever Seen:” Heart Development Comes Alive

A Q&A with Gladstone Investigator Benoit Bruneau

Research (Publication) Congenital Heart Disease Cardiovascular Disease Bruneau Lab

Article February 18, 2022

Getting to the Heart of Complex Disease

Gladstone researchers develop robust strategy for sifting through large-scale genetic data to better understand congenital heart problems

News Release Research (Publication) Congenital Heart Disease Cardiovascular Disease Krogan Lab Pollard Lab Srivastava Lab Stem Cells/iPSCs

Gladstone in the News February 3, 2021

San Francisco Researchers Use Genetic Clues to Identify Possible Drug for Treating Heart Conditions

ABC7 News—Gladstone President Deepak Srivastava, MD, a pediatric cardiologist, explains how his group discovered a potential new drug to treat a debilitating disease due to the hardening of heart valves.

Gladstone Experts Congenital Heart Disease Cardiovascular Disease Srivastava Lab Stem Cells/iPSCs

Article December 14, 2020

Study Reveals Networks of Genes Involved in Congenital Heart Disease

The findings could point toward new ways to prevent or treat one of the most common birth defects

News Release Research (Publication) Congenital Heart Disease Cardiovascular Disease Bruneau Lab Human Genetics Stem Cells/iPSCs

Article October 15, 2020

Gladstone Investigators Receive 4D Nucleome Award from the NIH

Benoit Bruneau and Katie Pollard study DNA folding to identify the genetic causes of congenital heart disease

Grants News Release Congenital Heart Disease Cardiovascular Disease Data Science and Biotechnology Bruneau Lab Pollard Lab

Gladstone in the News June 29, 2020

“The Heart and Human Development” Featuring Dr. Benoit Bruneau

The Stem Cell Podcast—Senior Investigator Benoit Bruneau describes his lab's recent work, including their use of stem cells to model and and understand congenital heart diseases, their investigation of the role of epigenetics in human development, and their sequencing of the Komodo dragon's genome, as well as his motivation and his path to science.

Gladstone Experts Congenital Heart Disease Cardiovascular Disease Bruneau Lab Disease Models Genomics Human Genetics Regenerative Medicine

Gladstone in the News April 7, 2020

Tackling Heart Disease

The Stem Cell Podcast—Gladstone President Deepak Srivastava describes his work using human induced pluripotent stem cells to investigate the gene networks that dictate cell fate decisions, and how this research could lead to therapeutics for congenital heart disease and heart failure. He also describes the importance of stem cell research in fighting the COVID-19 pandemic.

Gladstone Experts COVID-19 Heart Failure Congenital Heart Disease Cardiovascular Disease Roddenberry Stem Cell Center Srivastava Lab Stem Cells/iPSCs

Article February 24, 2020

Tackling Heart Disease: It Takes a Team

Gladstone researchers are collaborating to solve cardiovascular diseases using new technologies.

Gladstone Experts Research (Publication) Heart Failure Congenital Heart Disease Cardiovascular Disease Data Science and Biotechnology Infectious Disease Bruneau Lab Conklin Lab Krogan Lab

Article July 29, 2019

Dragon Heart

First sequence of the Komodo dragon genome reveals clues about its evolution

News Release Research (Publication) Congenital Heart Disease Bruneau Lab Pollard Lab Big Data