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The Race to Supercharge Cancer-Fighting T Cells

Gladstone in the News January 26, 2023

The Race to Supercharge Cancer-Fighting T Cells

Nature—Alex Marson, MD, PhD, director of the Gladstone-UCSF Institute of Genomic Immunology, and his colleagues have been using CRISPR to increase the therapeutic potential of T cells. This work is part of a worldwide effort to improve the design and manufacturing of cancer-killing ‟CAR-T” cells reviewed in the journal Nature.

Gladstone Experts Cancer Genomic Immunology Marson Lab CRISPR/Gene Editing

What If Cells Kept Receipts of Their Gene Expression?

Gladstone in the News August 12, 2022

What If Cells Kept Receipts of Their Gene Expression?

Wired—Measuring which genes are on and which are off in a cell usually requires killing it, meaning any measurement is simply a snapshot in time. Seth Shipman explains how his lab has circumvented this problem by re-engineering parts of a bacterial immune system to create a record of molecular events within a cell.

Gladstone Experts Data Science and Biotechnology Shipman Lab CRISPR/Gene Editing

New DNA ‘Camcorders’ Can Record ‘Movies’ of a Cell’s Development Through Time

Gladstone in the News August 2, 2022

New DNA ‘Camcorders’ Can Record ‘Movies’ of a Cell’s Development Through Time

Singularity Hub—Genomics tools allow scientists to get a glimpse of what genes are turned on in a cell at one particular moment, but understanding how genes are turned on or off over time, and in what order, has been impossible. Gladstone Investigator Seth Shipman has developed a biological recorder that keeps track of these events, offering a window into how cells change over time.

Gladstone Experts Data Science and Biotechnology Shipman Lab CRISPR/Gene Editing

At Home, on Your Phone, Results in Minutes: How COVID Has Changed the Future of Health Tests

Gladstone in the News April 8, 2021

At Home, on Your Phone, Results in Minutes: How COVID Has Changed the Future of Health Tests

San Francisco Business Times—Senior Investigator Melanie Ott, MD, PhD, and Graduate Student Parinaz Fozouni explain how the CRISPR- and smartphone-based diagnostic platform they recently developed with UC Berkeley Dan Fletcher, PhD, and Nobel Laureate Jennifer Doudna, PhD, could allow low-cost and widespread testing and help to quickly curb the course of this and future pandemics.

COVID-19 Virology Doudna Lab Ott Lab CRISPR/Gene Editing

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