Benoit Bruneau’s lab is broadly interested in understanding how genes are turned on and off during human development, and how this process is controlled during the formation of the heart in the embryo. Specifically, his team is investigating how errors in this process cause congenital heart disease. They use mouse models and human induced pluripotent stem (iPS) cells to unravel the transcription factor networks that regulate sets of genes critical for heart development.

Disease Areas

Birth Defects
Congenital Heart Disease
Heart Failure

Areas of Expertise

CRISPR and Genome Editing
Disease Models
Gene Regulation
Heart Development
Human Genetics
Stem Cells
BenoitElphege.jpg

Lab Focus

Studying the actions of chromatin remodeling complexes and epigenetic regulators on cardiac genes and their role in heart development and function.
Understanding interactions between disease-related transcription factors and chromatin modifying complexes in the regulation of cardiac morphogenesis.
Investigating the cellular regulation of important morphogenetic processes, such as cardiac septation.

Research Impact

Research in Bruneau’s lab is important for understanding basic concepts in gene regulation and how they are dysregulated in disease. They demonstrated interactions between cardiac transcription factors, which provided new insights into the tight regulation of gene cohorts and has had immediate implications in understanding how mutations in these genes cause similar heart defects. These findings are broadly impactful as they apply to any set of transcription factors, in any cell type. In addition, his team’s work on a protein called CTCF and 3D genome organization resolved several long-standing questions in biology applicable to all cells in the body.

 

Professional Titles

Director, Gladstone Institute of Cardiovascular Disease

William H. Younger Chair in Cardiovascular Research, Gladstone Institutes

Professor, Department of Pediatrics, UC San Francisco

Bio

Benoit G. Bruneau, PhD, is the director of the Gladstone Institute of Cardiovascular Disease and a senior investigator at Gladstone Institutes. He is also a professor of pediatrics at UC San Francisco.

Originally from Canada, Bruneau earned a bachelor’s degree in biology and a doctorate in physiology at the University of Ottawa. He completed a postdoctoral fellowship in the Department of Genetics at Harvard University Medical School in the lab of Jonathan and Christine Seidman. Before coming to Gladstone, Bruneau led a lab at The Hospital for Sick Children in Toronto and was an assistant professor in the Department of Molecular and Medical Genetics at the University of Toronto.

Holder of the William H. Younger Chair in Cardiovascular Research, he has distinguished himself internationally as a leading figure in the field of epigenetics and gene regulation, particularly as it relates to cardiac biology and disease. He also serves as an editor for the journal Development and sits on the editorial board of Genes & Development.

How Did You Get Your Start In Science?

“My third-year undergraduate developmental biology class had a hands-on Axolotl embryology lab. We did classic fate-map experiments, and beating heart explants. I was hooked.”

Benoit Bruneau, PhD

Honors and Awards

2012 American Heart Association (Fellow)

2010 Established Investigator Award (5 years), Lawrence J. and Florence A. DeGeorge Charitable Trust/American Heart Association

2003 Premier’s Research Excellence Award, Canada

2001 New Investigator Award, Heart and Stroke Foundation of Canada/Canadian Institutes of Health Research

Publications

More Publications

Contact

Benoit Bruneau

415.734.2708

Nicole Velasquez
Executive Assistant
415.734.4005


Lab Members

Andrew Blair, MS
Research Associate II
Walter Devine, MD, PhD
Visiting Scientist
Matthew George, PhD
Visiting Scientist
Zoe Grant, PhD
Postdoctoral Scholar
Jenny He
Graduate Student
Swetansu Hota, PhD
Scientist
Austin Hsu
Graduate Student
Kevin Hu
Research Associate I
Vasumathi Kameswaran, PhD
Scientist
Irfan Kathiriya, MD, PhD
Visiting Scientist
Alexis Krup
Graduate Student
Michael Lai, PhD
Visiting Scientist
Elphege-Pierre Nora, PhD
Visiting Scientist
Kavitha Rao, PhD
Senior Research Associate
Rui Wang
Research Associate I
Sarah Winchester
Research Associate II
Jingshing Wu
Visiting Scientist