Gladstone Scientific Advisory Board

Emery N. Brown, MD, PhD

Edward Hood Professor of Medical Engineering and Computational Neuroscience,
Massachusetts Institute of Technology
Warren M. Zapol Professor of Anesthesia, Harvard Medical School

Emery Brown is an anesthesiologist at Massachusetts General Hospital and a statistician at MIT. His experimental research has made important contributions towards understanding how anesthetics act in the brain to create the states of general anesthesia. His work in statistics has generated algorithms that solve important challenges in the analysis of neuroscience data.

Brown is a member of the National Academies of Science, Engineering, and Medicine.

George Q. Daley, MD, PhD

Dean of the Faculty of Medicine
Caroline Shields Walker Professor of Medicine
Harvard Medical School

George Q. Daley is an internationally recognized leader in stem cell science and cancer biology and a long-time Harvard Medical School faculty. He has testified before Congress and spoken in forums worldwide on the scientific and ethical dimensions of stem cell research and its promise in treating disease.

Daley’s research uses mouse and human disease models to identify mechanisms that underlie blood disorders and cancer, and aims to understand how stem cells contribute to tissue regeneration and repair. Daley’s earlier work on the BCR/ABL protein in chronic myelogenous leukemia provided critical support for the development of the highly successful chemotherapeutic agent Gleevec.

Daley was elected to the National Academy of Medicine in 2011.

Joseph Goldstein, MD

Julie and Louis A. Beecherl, Jr., Distinguished Chair in Biomedical Research
Regental Professor
Paul J. Thomas Chair in Medicine
Professor & Chair, Department of Molecular Genetics
University of Texas Southwestern Medical Center at Dallas

Joe Goldstein and his colleague, Michael S. Brown, have been recognized with many awards for their work on cholesterol, including the Lasker Award in Basic Medical Research (1985), Nobel Prize in Physiology or Medicine (1985), and National Medal of Science (1988). Their discovery of the low density lipoprotein (LDL) helped lay the groundwork for the development of statins, drugs that lower blood LDL-cholesterol and prevent heart attacks.

Goldstein is currently Chairman of the Albert Lasker Medical Research Awards Jury and is a member of the Boards of Trustees of the Howard Hughes Medical Institute and The Rockefeller University. He is also a member of the National Academy of Sciences, National Academy of Medicine, and a Foreign Member of the Royal Society.

Eric N. Olson, PhD

Professor and Chair, Department of Molecular Biology
Annie & Willie Nelson Professor in Stem Cell Research
Pogue Distinguished Chair in Research on Cardiac Birth Defects
Robert A. Welch Distinguished Chair
University of Texas Southwestern Medical Center at Dallas

Eric Olson and his trainees discovered many of the genes that control heart and muscle formation and disease. These discoveries have revealed fundamental principles of tissue formation and provided new concepts in the quest for treatments for muscle and cardiovascular diseases. For instance, Olson’s most recent work has provided a new strategy for correcting Duchenne muscular dystrophy with CRISPR technology.

Olson has co-founded multiple biotechnology companies to develop therapies for heart and muscle disease, including Myogen, Miragen, Tenaya Therapeutics and Exonics. He is also a member of the US National Academy of Sciences, the Institute of Medicine, and the American Academy of Arts and Sciences.

Aviv Regev, PhD

Genentech Research and Early Development

Aviv Regev is executive vice president of Genentech Research and Early Development. Her research focuses on the molecular circuitry that governs the function of mammalian cells. She pioneered many leading experimental and computational methods for the reconstruction of circuits, including in single-cell genomics.

Prior to joining Genentech, Regev was a professor of biology at MIT and a Howard Hughes Medical Institute investigator. She is a recipient of the Overton Prize from the International Society for Computational Biology (ISCB), and is an elected member of the National Academy of Sciences and the National Academy of Medicine.

Charles M. Rice, PhD

Maurice R. And Corinne P. Greenberg Professor in Virology
The Rockefeller University

Charles Rice is the Maurice R. and Corinne P. Greenberg chair in virology at The Rockefeller University. Rice discovered the hepatitis C virus (HCV), produced the first infectious molecular clone of the virus, and established cell culture systems and animal models for studying HCV replication and evaluating antivirals.

Rice is a past president of the American Society for Virology, a fellow of the American Association for the Advancement of Science, a member of the National Academy of Sciences, and a recipient of the Nobel Prize in Physiology or Medicine.

Arlene Sharpe, MD, PhD

George Fabyan Professor of Comparative Pathology
Chair, Department of Immunology
Co-Director, Evergrande Center for Immunologic Diseases
Harvard Medical School

Arlene Sharpe is the George Fabyan Professor of Comparative Pathology and chair of the Department of Immunology at Harvard Medical School. Her laboratory discovered the immunoinhibitory functions of the CTLA-4 and PD-1 pathways, which have become exceptionally promising targets for cancer immunotherapy. Sharpe’s research currently focuses on translating fundamental understanding of T cell costimulation into new therapies for autoimmune diseases and cancer.

Sharpe is a past president of the American Association of Immunologists. She is an elected member of the National Academy of Sciences and National Academy of Medicine and a fellow of the American Association for Cancer Research.

Li-Huei Tsai, PhD

Director, the Picower Institute for Learning and Memory at MITPicower
Picower Professor of Neuroscience
Professor of Neuroscience, Department of Brain and Cognitive Sciences
Senior Associate Member, Broad Institute
Massachusetts Institute of Technology

Li-Huei Tsai is the director of the Picower Institute for Learning and Memory, co-director of the Alana Down Syndrome Center, and co-founder of the Aging Brain Initiative at MIT. Prior to joining MIT, she was faculty in the Department of Pathology at Harvard Medical School and a Howard Hughes Medical Institute investigator. Tsai’s laboratory takes a multidisciplinary approach to elucidate the molecular, cellular, and circuit basis of neurological disorders that impact learning and memory.

Tsai is a member of the American Academy of Arts and Sciences and the National Academy of Medicine.

Huda Zoghbi, MD

Baylor College of Medicine
Howard Hughes Medical Institute

Huda Zoghbi is a professor in the Departments of Pediatrics, Molecular and Human Genetics, Neurology and Neuroscience at Baylor College of Medicine. She is also an investigator at the Howard Hughes Medical Institute and the director of the Jan and Dan Duncan Neurological Research Institute (NRI) at Texas Children's Hospital. Zoghbi’s laboratory uses genetic, cell biological, and biochemical approaches to explore the pathogenesis of polyglutamine neurodegenerative diseases and neurodevelopmental disorders.

Zoghbi has been elected to the National Academy of Medicine, the National Academy of Sciences, and the American Academy of Arts and Sciences.