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Genetic Engineering & Biotechnology News—In addition to genetic changes, environmental factors are associated with the development of birth defects. A new study led by Deepak Srivastava, president of Gladstone Institutes, reveals how maternal diabetes alters a small subset of cells in the developing heart in a way that can lead to congenital heart defects.
Gladstone Experts Congenital Heart Disease Diabetes Cardiovascular Disease Srivastava Lab Single CellThe cutting-edge research methods that led to the discovery could be used to find other connections between environmental factors and birth defects.
News Release Research (Publication) Cardiovascular Disease Srivastava LabGenetic Engineering & Biotechnology News—Scientists at the Gladstone Institutes have published a paper in Cell Reports that describes a CRISPR-based technique for treating primary glioblastoma, a common and aggressive form of brain cancer. The paper, titled “Targeting the non-coding genome and temozolomide signature enables CRISPR-mediated glioma oncolysis,” describes the technique, which the researchers have called “genome shredding.”
Research (Publication) Cancer Genomic Immunology Doudna Lab CRISPR/Gene EditingGladstone Institutes researchers leveraged CRISPR to target and rapidly destroy glioblastoma cells in an approach that could carry over to other highly mutated cancers
News Release Research (Publication) Cancer Doudna Lab CRISPR/Gene EditingFortune—Researchers are investigating the possibility that people who suffer from Long COVID might be at elevated risk of developing cancer. Melanie Ott, director of the Gladstone Institute of Virology, explains that viruses related to SARS-CoV-2 have been shown to inactivate oncosuppressor proteins, which may predispose patients to cancer.
Gladstone Experts Cancer COVID-19 Virology Ott LabDorman served as a Gladstone trustee for over 30 years
History ProfileMagdalena Zernicka-Goetz, recipient of the 2023 Ogawa-Yamanaka Stem Cell Prize, has created self-assembling embryo-like models that are advancing regenerative medicine
Awards Ogawa Stem Cell Prize Profile Stem Cells/iPSCsResearch Associate Christina Buselli describes her work in the Finkbeiner lab, her path to science, and the questions she wishes she could ask her grandfather
Profile Finkbeiner LabNew research sheds light on protective mechanisms of the “Christchurch mutation”
News Release Research (Publication) Alzheimer’s Disease Center for Translational Advancement Neurological Disease Huang LabThe award recognizes leaders who have made major contributions to the fields of cardiovascular and stroke science
Awards News Release Cardiovascular Disease Srivastava LabA novel method developed by Gladstone researchers is already answering longstanding questions about basic DNA dynamics—and may one day lead to new ways of treating cancer and other conditions
News Release Research (Publication) Data Science and Biotechnology Ramani Lab Big DataAHA with JAHA Podcast—In a roundtable forum, the American Heart Association’s 2023 Distinguished Scientists describe their contributions to stroke and cardiovascular research. Gladstone President Deepak Srivastava discusses the use of human iPS cells in drug discovery and his hopes for the future of science and medicine, including applications of artificial intelligence.
Gladstone Experts Congenital Heart Disease Cardiovascular Disease Srivastava Lab Human Genetics Stem Cells/iPSCsGladstone researchers discovered how the ApoE4 gene variant makes neurons release an inflammatory signaling molecule—and how blocking that release could prevent or treat Alzheimer’s disease
News Release Research (Publication) Alzheimer’s Disease Neurological Disease Huang LabSoftware developers and their mentors at Gladstone help advance research through Google Summer of Code
Bioinformatics Core Data Science and Biotechnology Big Data Pico