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New research shows low oxygen can help alleviate disease caused by defects in a mitochondrial quality control machinery.
News Release Research (Publication) Jain Lab Metabolism
A new framework that matches vitamins with genetic diseases helped uncover that high-dose vitamin B3 can dramatically extend survival in mice with NAXD deficiency.
News Release Research (Publication) Rare Diseases Jain Lab
The Scientist—Gladstone Investigator Isha Jain discovered that hypoxic conditions trigger red blood cells to absorb and utilize more glucose, reducing blood sugar and offering a potential therapy to control diabetes.
Gladstone Experts Diabetes Jain Lab
Reuters—Led by Gladstone Investigator Isha Jain, researchers found that low-oxygen conditions cause red blood cells to act like “glucose sponges,” lowering blood sugar.
Gladstone Experts Diabetes Jain Lab
New study shows red blood cells act as hidden glucose sponges in low-oxygen conditions, explaining why people living at high altitude have lower diabetes rates and pointing toward new treatments.
News Release Research (Publication) Diabetes Jain Lab
From fundamental insights to translational advances, here’s how Gladstone researchers moved science forward in 2025.
Gladstone Experts Alzheimer’s Disease Autoimmune Diseases COVID-19 Neurological Disease Genomic Immunology Cardiovascular Disease Data Science and Biotechnology Infectious Disease Conklin Lab
Leveraging modern scientific tools and techniques, Jain intends to transform our understanding of the critical roles that vitamins play in health and disease.
Awards News Release Cardiovascular Disease Jain Lab Metabolism
Isha Jain and Skyler Blume explain the science behind their discovery and the impact it could have for mitochondrial diseases.
Research (Publication) Jain Lab
Science Alert—Gladstone Investigator Isha Jain and her colleagues developed a drug that reduces oxygen delivery from blood to tissues and could help prevent brain damage caused by diseases that cause a toxic oxygen buildup.
Jain Lab Cardiovascular Disease
Gladstone researchers develop a drug that mimics the cellular effects of low-oxygen therapy for the treatment of inherited mitochondrial diseases.
News Release Research (Publication) Jain Lab
Arc Institute—Gladstone investigator Isha Jain joins Arc Institute's new cohort of core investigators to drive visionary research into complex human disease. She will receive unrestricted funding to advance her research on how the body senses and responds to variations in oxygen levels and vitamins.
Grants Jain Lab
A new study from Gladstone Institutes sheds light on the molecular workings at play when oxygen exceeds normal levels, with findings that may one day inform the decision to use supplemental oxygen as a medical treatment
News Release Research (Publication) Cardiovascular Disease Jain Lab
High levels of oxygen can cause lasting health problems in humans. Now scientists know why.
News Release Research (Publication) Cardiovascular Disease Jain Lab CRISPR/Gene Editing
When mice are exposed to chronically low levels of oxygen, similar to those experienced at 4,500 meters of elevation, their metabolism changes
News Release Research (Publication) Cardiovascular Disease Jain Lab
Graduate Student Will Flanigan shares the importance of LGBTQ+ representation in STEM
LGBTQ Jain Lab Shipman Lab
