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Researchers used virus-like particles to identify which mutations of the Omicron SARS-CoV-2 virus make it more effective at infecting cells and escaping antibodies
News Release Research (Publication) COVID-19 Virology Doudna Lab Ott Lab
Gladstone researchers find new evidence against using BET inhibitors to treat COVID-19
News Release Research (Publication) COVID-19 Virology Ott Lab
ABC7 News—As Omicron BA.4 and BA.5 variants overtake previous coronavirus variants across the United States, Gladstone Associate Investigator Nadia Roan, PhD, explains that their success may owe both to their ability to escape our immune system and to their accelerated replication rate. She suggests that more effort should be made to block infection at the level of the airways, the virus's entry point into our body.
Gladstone Experts COVID-19 Roan Lab
San Francisco Chronicle—A year has passed since California dropped most public health restrictions related to COVID-19, but the pandemic isn’t over. Senior Investigator Warner Greene notes that the virus is still spreading effectively, and people can be infected repeatedly with different subvariants.
Gladstone Experts COVID-19 Virology Greene Lab
San Francisco Chronicle—A study in the Mission District of San Francisco tracked how COVID-19 symptoms have changed over the course of the pandemic. Gladstone virologist Nadia Roan explains that the Omicron variant infects the upper respiratory tract and triggers a localized immune response, which may in part explain why individuals infected during the Omicron wave were less likely to experience severe illness.
Gladstone Experts COVID-19 Virology Roan Lab
Washington Post—Even as COVID restrictions are easing, case numbers are rising around the country. Melanie Ott, director of the Gladstone Institute of Virology, explains that recent research from her group shows that individuals infected with the Omicron variant have limited natural immunity, and may still be susceptible to infection with Omicron subvariants.
Gladstone Experts COVID-19 Virology Ott Lab
ABC News—Gladstone virologists investigated the effect of the Omicron variant on the immune response. Melanie Ott describes her team’s discovery that previous infection with Omicron does not result in strong immunity to other known SARS-CoV-2 variants. However, as Nadia Roan explains, individuals who were vaccinated before becoming infected with Omicron did have a broadly protective immune response, emphasizing the importance of the vaccines in saving lives.
Gladstone Experts COVID-19 Virology Doudna Lab Greene Lab Ott Lab Roan Lab
UCSF News—Nevan Krogan, PhD, a senior investigator at Gladstone and the director of the Quantitative Biosciences Institute at UC San Francisco, leads a vast, international collaborative effort to find drugs against COVID-19 called the QBI Coronavirus Research Group (QCRG). The group recently received $67.5 million from the National Institutes of Health, the largest such award in UCSF's history, to pursue work on coronaviruses and other viruses with pandemic potential.
Gladstone Experts COVID-19 Data Science and Biotechnology Krogan Lab
USA Today—When the Omicron variant of SARS-CoV-2 swept the country this winter, many had hoped it might help move the population closer to herd immunity. However, Director of the Gladstone Institute of Virology Melanie Ott describes her team’s research that shows that previous infection with Omicron does not provide strong protection against infection with other variants.
Gladstone Experts COVID-19 Virology Ott Lab
Without vaccination, infection with Omicron fails to confer robust immunity against other COVID-19 variants
News Release Research (Publication) COVID-19 Virology Doudna Lab Ott Lab Roan Lab
ABC News—COVID-19 case numbers are rising in the San Francisco Bay Area, driven by sublineages of the Omicron variant. Gladstone virologist Warner Greene explains that the new subvariants are more infectious, and can evade the antibodies produced in response to vaccination and previous infection.
Gladstone Experts COVID-19 Virology Greene Lab
STAT News—COVID-19 case numbers are rising once again across the United States. Melanie Ott, director of the Gladstone Institute of Virology, explains that the virus is adapting to a new immune landscape, with variants emerging that are able to cause infection even in individuals who were previously infected.
Gladstone Experts COVID-19 Virology Ott Lab
An in-depth explainer about what happens in the body after vaccination, and how COVID-19 vaccines compare to other vaccines
Gladstone Experts COVID-19 Deep Dive
KCBS News—Although Omicron and related new variants can infect vaccinated people, Senior Investigator Warner Greene says vaccines still protect us well against severe disease, and urges people to get at least one booster shot.
Gladstone Experts COVID-19 Center for HIV Cure Research Greene Lab
ABC News—The FDA recently announced that they would authorize a second COVID-19 vaccine booster shot for people 50 and older, and those 12 and older who are immunocompromised. Senior Investigator Warner Greene explains that the second booster can protect people who don’t have vigorous immune systems from infection, and predicts that it may be more broadly recommended for all adults in the months to come.
Gladstone Experts COVID-19 Virology Greene Lab
