Scientists from Gladstone Institutes, UC San Francisco, and Stanford University, stress-tested genes across the genome in 22 million human immune cells. By using actual human immune cells from blood donors, they could observe how genes function in their natural state.

The resulting dataset helps decode how these genes actually work and how they impact health and disease. It also stands as the largest contribution yet to the Billion Cells Project, a massive effort led by Biohub.

In this video, Gladstone scientists Emma Dann and Ronghui Zhu explain the importance of this study and how it offers a powerful new framework for designing cancer immunotherapies and treating autoimmune conditions.

The study, published in Cell, was led by Alex Marson’s lab at Gladstone and UCSF, in close collaboration with Jonathan Pritchard at Stanford.

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