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Bruce Conklin, MD, introduces you to CRISPR, a disruptive technology influencing advances in treatment and cures of diseases through gene editing. Conklin walks you through how CRISPR works before diving into its evolution in his lab at Gladstone, using application examples such as treating cancer, curing Alzheimer’s, and testing drug therapies to prevent cardiac damage in COVID-19 patients. You’ll also hear about this DNA-editing technology’s bright future expanding its reach into cures for more diseases.
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From fundamental insights to translational advances, here’s how Gladstone researchers moved science forward in 2025.
Gladstone Experts Alzheimer’s Disease Autoimmune Diseases COVID-19 Neurological Disease Genomic Immunology Cardiovascular Disease Data Science and Biotechnology Infectious Disease Conklin LabIn this video, Gladstone scientists share how they used stem cells, gene editing, and AI to identify a gene driving heart defects in Down syndrome—and how reducing its levels in mice restored normal heart development, offering hope for future treatments
Gladstone Experts Cardiovascular Disease Data Science and Biotechnology Pollard Lab Srivastava Lab AI Big Data CRISPR/Gene Editing Human Genetics Stem Cells/iPSCsIn this video, Steve Finkbeiner and Jeremy Linsley showcase Gladstone’s groundbreaking “thinking microscope”—an AI-powered system that can design, conduct, and analyze experiments autonomously to uncover new insights into diseases like Alzheimer’s, Parkinson’s, and ALS.
Gladstone Experts ALS Alzheimer’s Disease Parkinson’s Disease Neurological Disease Finkbeiner Lab AI Big Data