Crystal Mackall, MD
Crystal Mackall, MD, is a professor of pediatrics and medicine at Stanford University School of Medicine, where she also leads the Cancer Immunology and Immunotherapy Program and serves as Associate Director of the Stanford Cancer Institute. During a 27-year tenure at NCI culminating as Chief of the Pediatric Oncology Branch and Head of the Immunology Section and since 2016 at Stanford, she has led an internationally recognized translational research program focused on immune-oncology. She has led numerous first-in-human and first-in-child clinical trials spanning dendritic cell vaccines, cytokines, and adoptive immunotherapy using NK cells and genetically modified T cells. Dr. Mackall is credited with identifying the essential role of the thymus in human T cell regeneration and discovering IL-7 as the master regulator of T cell homeostasis. Her group was one of the first to demonstrate impressive activity of CD19-CAR in pediatric leukemia.
The Mackall lab seeks to discover fundamental principles that control tumor-immune interactions and to apply these insights to develop novel immunotherapies for cancer. Current areas of major focus include in depth studies of the molecular and cellular processes that govern T cell exhaustion, identification of new immune targets expressed by cancer and leveraging emerging synthetic biology platforms to create next generation chimeric antigen receptors that manifest enhanced potency, regulatability, multispecificity and exhaustion resistance.
DatesJanuary 16, 2024
LocationGladstone Mahley Auditorium & Online
AudienceGladstone and UCSF
The Gladstone-UCSF Institute of Genomic Immunology Seminar Series showcases speakers at the intersection of genomic technology and immunology research with an aim to engineer the human immune system for therapeutic benefit. Speakers span technology development, synthetic biology, bioengineering, and the development and clinical application of immunotherapy. These talks are open to the Gladstone and UCSF communities.
Diversity, Equity, and Inclusion
At Gladstone, we are committed to providing events and professional development activities that resonate with our community’s diverse members. Our goal is to develop creative programming that encompasses a wide variety of ideas and perspectives to inspire, educate, and engage with everyone within our walls.
We want to effect positive change through our events and activities by providing a platform for discussions on important topics related to increasing diversity and inclusiveness in the sciences.