Gladstone maintains an active and diverse intellectual property (IP) portfolio around technologies, novel approaches to treating disease, and specific therapies.

Several options for licensing Gladstone IP are available to both new start-ups, established companies, and research institutions.

Contact the Corporate Liaison and Ventures team for more information on licensing opportunities.

Patents

Additional technologies not listed here may be available for discussion under confidential disclosure agreement. Contact our legal team for licensing inquiries.

Title Patent or Publication Number
Chemical Reprogramming to Generate Neuronal Cells US Patent Publication No. US 2019/0010451
Methods of Treating Disease by Metabolic Control of T-Cell Differentiation US Patent Publication No. US 2019/0022142
Generation of Expandable Cardiovascular Progenitor Cells US Patent Publication No. US 2019/0017029
Methods and Compositions for Treating Obesity and/or Diabetes and for Identifying Candidate Treatment Agents US Patent Publication No. US 2019/0106394
Compositions and Methods for Reactivating Latent Immunodeficiency Virus US Patent Publication No. US 2018/0002699
Methods for Modulating Genome Editing US Patent Publication No. US 2018/0016601
Reversion of Primed Pluripotent Stem Cells to Naive Pluripotent Stem Cells US Patent Publication No. US 2018/0142206
Methods and Compositions for Producing Pancreatic Beta Cells US Patent Publication No. US 2018/0216076
Methods for Treating a Cytomegalovirus Infection US Patent Publication No. US 2017/0360778
In Vitro Methods of Differentiating Stem Cells into Neurons and Neurons Generated Using the Same International Publication No. WO 2017/210138
Methods for Inducing Cardiomyogenesis US Patent Publication No. US 2016/0194608
Detection of Genome Editing US Patent Publication No. US 2016/0208319
Small Molecule Cellular Reprogramming to Generate Neuronal Cells US Patent Publication No. US 2016/0250260
Automated Robotic Microscopy Systems US Patent Publication No. US 2015/0278625
Compositions, Systems, and Methods for Gene Expression Noise Drug Screening and Uses Thereof US Patent No. 10,184,933
Compositions and Methods of Use Thereof for Identifying Anti-Viral Agents US Patent No. 10,106,817
Dual-Color HIV Reporter System for the Detection of Latently Infected Cells US Patent No. 10,106,818
Substituted Benzoxazine and Related Compounds US Patent No. 10,087,151 and US Patent Publication No. US 2019/0000817
Compositions and Methods for Treating Dengue Virus Infection US Patent No. 10,004,751
Generating Definitive Endoderm and Pancreatic Progenitor Cells US Patent No. 9,909,104
Generating Hepatocytes US Patent Nos. 9,512,406 and 10,227,565
Methods of Modulating Smooth Muscle Cell Proliferation and Differentiation US Patent Nos. 8,735,568 and 9,364,506
Methods of Promoting CNS Neuronal Repair by Inhibiting LRP-1 US Patent No. 9,376,481
Compositions and Methods for Regulating Glucose Metabolism US Patent No. 9,562,072
Methods of Generating Neural Stem Cells US Patent Nos. 8,815,589 and 9,249,391
Methods for the Reactivation of Latent HIV Using Cytosine Methylation Inhibitors and NF-ΚB Activators US Patent No. 9,474,788
Compositions and Methods for Treating Neurological Disorders US Patent No. 9,359,445
Methods of Treating Neurodegenerative Disease US Patent No. 9,101,644
Treatment of HIV-1 Infection and AIDS US Patent Nos. 9,956,260 and 9,352,010
Methods and Compositions for Reducing Amyloid Beta Levels US Patent Nos. 8,420,613; 8,691,519; and 9,347,085
Use of SIRT1 Activators or Inhibitors to Modulate an Immune Response US Patent No. 8,748,464
Methods of Modulating Lipid Concentrations in Eukaryotic Cells US Patent No. 8,435,790
Method for Identifying Agents Capable of Inhibiting APOBEC3C Activity in HIV-Infected Cells US Patent No. 8,133,666
Small Molecule Inhibitors of Kynurenine-3-Monooxygenase US Patent Nos. 8,071,631; 7,994,338; and 8,466,182
Method of Increasing Cathepsin B-Induced Cleavage of Amyloid-Β Peptides US Patent No. 8,388,953
Inhibitors of Kynurenine-3-Monooxygenase US Patent No. 8,710,237
Methods and Compositions for the Synergistic Activation of Latent HIV US Patent No. 8,247,613
Methods of Treating Smooth Muscle Cell Disorders US Patent No. 8,114,853
Diacylglycerol O-Acyltransferase 2α (DGAT2α) US Patent No. 7,862,819
Methods for Treating Lentivirus Infections US Patent Nos. 7,723,021 and 8,338,180
Methods and Compositions for Reducing Amyloid Beta Levels US Patent No. 7,951,367
Immunogenic Compositions Comprising HIV-1 Acetylated Tat Polypeptides US Patent No. 7,482,016
Methods of Detecting Neurological Disorders US Patent No. 7,297,836
Acyl CoA: Cholesterol Acyltransferase (ACAT-2) US Patent Nos. 6,579,974; 6,869,937; and 7,238,779
Robotic Microscopy Systems US Patent No. 7,139,415
Histone Deacetylase and Methods of Use Thereof US Patent No. 7,488,587
Virion-Based Fusion Assay US Patent No. 7,250,251
Mouse Model of Chronic Heart Failure and Coronary Atherosclerosis Regression US Patent No. 7,960,606
Methods and Tools for Identifying Compounds Which Modulate Atherosclerosis by Impacting LDL-Proteoglycan Binding US Patent Nos. 6,579,682 and 7,038,011
Inhibitor of the Inflammatory Response Induced by Tnfα and IL-1 US Patent Nos. 6,265,538 and 6,645,728.
Selective Target Cell Activation by Expression of a G-Protein-Coupled Receptor Activated Superiorly by Synthetic Ligand US Patent No. 6,518,480
Transgenic Mice Expressing Human APP and TGF-Β Demonstrate Cerebrovascular Amyloid Deposits US Patent No. 6,455,757
Cell Fusion Assays for the Identification of Antiviral Compounds, and Systems and Kits for Practicing the Same US Patent No. 6,451,598
Polymorphisms in a Diacylglycerol Acyltransferase Gene, and Methods of Use Thereof US Patent No. 6,444,427
Transgenic Rats and Rat Cell Lines Expressing Human CD4 and a Human Chemokine Receptor US Patent No. 6,372,956
Antibodies Specific for Proteins Having Polyglutamine Expansions US Patent No. 6,291,652
Transgenic Mouse Model of Alzheimer’s Disease and Cerebral Amyloid Angiopathy US Patent No. 6,175,057