Melanie Ott’s lab studies viruses that infect humans, and applies the lessons learned to new and emerging viruses. Founded at the peak of the AIDS epidemic, the lab has since broadened its scope from HIV to other viruses with global relevance such as Hepatitis C Virus, Zika Virus, and SARS-CoV-2. The Ott Lab combines broad expertise—in virology, cell biology, biochemistry, systems biology, and chromatin biology—with a diverse and highly collaborative approach. They focus on human-host factors restricting or enabling viral infections, and build and study complex primary cell systems, such as organoids, to model physiological conditions closely. Ott’s team leads the HOPE Collaboratory, an NIH-funded multidisciplinary research consortium dedicated to eradicating HIV.
Disease Areas
SARS-CoV-2
HIV/AIDS
Zika
Influenza
Immune Aging
Areas of Expertise
Virology
Chromatin Biology
Organoids
Lipid Droplets
CRISPR Diagnostics
Lab Focus
Developing a diagnostic platform that combines CRISPR-based biochemistry with smartphone optics for the rapid and quantitative detection of RNA viruses—including SARS-CoV-2 and HIV.
Utilizing human organoids derived from adult tissues, adult stem cells, or induced pluripotent stem cells to model infection of the lung, liver, intestine, brain, or airways.
Building a library of all the proteins encoded in the genomes of HIV, Zika, influenza, SARS-CoV-2, and others as a resource for the research community.
Adapting single-cell and bulk genomic, transcriptomic, and proteomic technology to analyze organoids and immune cells, and innovative chromatin tools to study latent HIV provirus.
Research Impact
The Ott Lab has uncovered a number of ways in which viruses harness the biology of human cells to their own benefit and to the detriment of their hosts. These findings pave the way for the development of therapies that target the virus-host interface.
For instance, the lab demonstrated the importance of non-histone protein acetylation in HIV transcription and latency, ushering in the use of drugs that block acetylation as a potential step toward the eradication of HIV. They discovered a major pathway explaining hepatitis C virus’s dependence on lipid droplets inside liver cells, and identified nonsense-mediated RNA decay as a new host defense against RNA viruses that is inactivated by Zika virus.
Since the beginning of the COVID-19 pandemic, Ott’s lab and collaborators developed a testing platform that detect SARS-CoV-2 RNA without amplification, using CRISPR/Cas13a and a mobile phone. The platform could be deployed for rapid molecular testing at home or at a point-of-care facility.
They have used genome-wide CRISPR screens to identify host pathways enabling the replication of SARS-CoV-2 and of common cold coronaviruses as the basis for new pan-coronaviral therapeutic strategies.
They have also characterized Delta, Epsilon, and Omicron variants with pseudotyped viruses, virus-like particles and full-length molecular clones to identify mutations in S and N proteins that increase viral spread.
Professional Titles
Director, Gladstone Institute of Virology
Senior Vice President, Gladstone Institutes
Senior Investigator, Gladstone Institutes
Professor, Medicine, UC San Francisco
Bio
A native of Germany, Melanie Ott, MD, PhD, is the director of the Gladstone Institute of Virology, a senior investigator at Gladstone Institutes, and a professor of medicine at UCSF.
Ott is passionate about using viruses to find fundamental new biology in host cells. She has made important discoveries about how viruses—including the hepatitis C virus and Zika—hijack human cells, and has contributed to efforts to eradicate HIV by gaining insight into viral transcriptional control. Since the outbreak of the COVID-19 pandemic, she pivoted the focus of her team and spearheaded the effort to establish a dedicated airborne pathogen BSL-3 lab to enable work on live SARS-CoV-2.
Prior to joining Gladstone in 2002, Ott started her own research group at the German Cancer Research Center in Heidelberg, Germany, working closely with Nobel laureate Harald zur Hausen. She is a trained neurologist with an MD from the University of Frankfurt/Main in Germany. She transitioned to basic virology research during the AIDS crisis, earning a PhD in molecular medicine from the Elmezzi Graduate School in Manhasset, New York.
Ott has received several honors, including the Young Researcher Award at the European Conference on Experimental AIDS Research and the Hellman Award. She is a member of the Association of American Physicians and a Fellow of the American Academy of Microbiology. She is a recipient of the Chancellor’s Award for Public Service from UCSF for her work as the founder and co-chair of the student outreach committee at Gladstone. Ott also received the California Life Sciences Association’s Biotechnology Educator Pantheon Award for establishing the PUMAS (Promoting Underrepresented Minorities Advancing in the Sciences) internship program at Gladstone, which seeks to increase diversity in STEM.
How Did You Get Your Start in Science?
“I worked as a neurologist when the first genome was sequenced and PCR was discovered. This triggered my passion for the molecular basis of diseases.”
Melanie Ott, MD, PhD
Honors and Awards
2019 NIH Merit Award, National Institutes of Health
2018 UCSF AIDS Research Institute Award for Outstanding Teaching and Mentoring
2018 Fellow of the American Academy of Microbiology (Elected)
2017 DiNA Award Biotechnology Educator of the Year, California Life Sciences Association (CLSA)
2014 Avant-Garde Award, National Institutes of Health
2013 Member of Association of American Physicians (Elected)
2008 Thomas N. Burbridge Award, UC San Francisco
2008 Sandler Opportunity Award, UC San Francisco
2008 UCSF Chancellor’s Award for Public Service, UC San Francisco
2006 Hellman Family Award, UC San Francisco
2000 Young Researcher Award, European Conference on Experimental AIDS Research, Madrid, Spain
1999 Young Research Award, European Conference on Experimental AID Research, Tampere, Finland
1991 Honors, Magna Cum Laude, University of Frankfurt/Main, Germany
1984 Scholarship, German National Merit Foundation
Publications
- A Single-Component Luminescent Biosensor for the SARS-CoV-2 Spike Protein. Ravalin M, Roh H, Suryawanshi R, Kumar GR, Pak JE, Ott M, Ting AY. J Am Chem Soc. 2022 08 03; 144(30):13663-13672.
- Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles. Syed AM, Ciling A, Taha TY, Chen IP, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Suryawanshi R, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Spraggon L, Tabata T, Ott M, Doudna JA. Proc Natl Acad Sci U S A. 2022 08 02; 119(31):e2200592119.
- Accelerating PERx reaction enables covalent nanobodies for potent neutralization of SARS-CoV-2 and variants. Yu B, Li S, Tabata T, Wang N, Cao L, Kumar GR, Sun W, Liu J, Ott M, Wang L. Chem. 2022 Oct 13; 8(10):2766-2783.
- Tropism of SARS-CoV-2 for human cortical astrocytes. Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Ross J, Parikshak N, Wang S, Zhou L, Koontz M, Velmeshev D, Siebert CV, Gemenes KM, Tabata T, Perez Y, Wang L, Mostajo-Radji MA, de Majo M, Donohue KC, Shin D, Salma J, Pollen AA, Nowakowski TJ, Ullian E, Kumar GR, Winkler EA, Crouch EE, Ott M, Kriegstein AR. Proc Natl Acad Sci U S A. 2022 07 26; 119(30):e2122236119.
- Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2. Chen IP, Longbotham JE, McMahon S, Suryawanshi RK, Khalid MM, Taha TY, Tabata T, Hayashi JM, Soveg FW, Carlson-Stevermer J, Gupta M, Zhang MY, Lam VL, Li Y, Yu Z, Titus EW, Diallo A, Oki J, Holden K, Krogan N, Fujimori DG, Ott M. Cell Rep. 2022 07 19; 40(3):111088.
- Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination. Matsui Y, Li L, Prahl M, Cassidy AG, Ozarslan N, Golan Y, Gonzalez VJ, Lin CY, Jigmeddagva U, Chidboy MA, Montano M, Taha TY, Khalid MM, Sreekumar B, Hayashi JM, Chen PY, Kumar GR, Warrier L, Wu AH, Song D, Jegatheesan P, Rai DS, Govindaswami B, Needens J, Rincon M, Myatt L, Asiodu IV, Flaherman VJ, Afshar Y, Jacoby VL, Murtha AP, Robinson JF, Ott M, Greene WC, Gaw SL. JCI Insight. 2022 06 22; 7(12).
- A single-component luminescent biosensor for the SARS-CoV-2 spike protein. Ravalin M, Roh H, Suryawanshi R, Kumar GR, Pak J, Ott M, Ting AY. bioRxiv. 2022 Jun 15.
- Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination. Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Gascon R, Tsou CL, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, George AF, Fang X, Maishan M, Matthay M, Morris MK, Wadford D, Hanson C, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna JA, Ott M. Nature. 2022 07; 607(7918):351-355.
- Immediate myeloid depot for SARS-CoV-2 in the human lung. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Res Sq. 2022 May 17.
- Immediate myeloid depot for SARS-CoV-2 in the human lung. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. bioRxiv. 2022 May 11.
- Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants. Servellita V, Syed AM, Morris MK, Brazer N, Saldhi P, Garcia-Knight M, Sreekumar B, Khalid MM, Ciling A, Chen PY, Kumar GR, Gliwa AS, Nguyen J, Sotomayor-Gonzalez A, Zhang Y, Frias E, Prostko J, Hackett J, Andino R, Wadford DA, Hanson C, Doudna J, Ott M, Chiu CY. Cell. 2022 04 28; 185(9):1539-1548.e5.
- Accelerating PERx Reaction Enables Covalent Nanobodies for Potent Neutralization of SARS-Cov-2 and Variants. Yu B, Li S, Tabata T, Wang N, Kumar GR, Liu J, Ott MM, Wang L. bioRxiv. 2022 Mar 14.
- Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system. Natarajan V, Simoneau CR, Erickson AL, Meyers NL, Baron JL, Cooper S, McDevitt TC, Ott M. Open Biol. 2022 03; 12(3):210320.
- Limited Cross-Variant Immunity after Infection with the SARS-CoV-2 Omicron Variant Without Vaccination. Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, George AF, Fang X, Maishan M, Matthay M, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna J, Ott M. medRxiv. 2022 Feb 09.
- SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein. Walter M, Chen IP, Vallejo-Gracia A, Kim IJ, Bielska O, Lam VL, Hayashi JM, Cruz A, Shah S, Gross JD, Krogan NJ, Schilling B, Ott M, Verdin E. bioRxiv. 2022 Jan 05.
- Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles. Syed AM, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Spraggon L, Taha TY, Tabata T, Chen IP, Ott M, Doudna JA. medRxiv. 2022 Jan 02.
- Viral E Protein Neutralizes BET Protein-Mediated Post-Entry Antagonism of SARS-CoV-2. Chen IP, Longbotham JE, McMahon S, Suryawanshi RK, Carlson-Stevermer J, Gupta M, Zhang MY, Soveg FW, Hayashi JM, Taha TY, Lam VL, Li Y, Yu Z, Titus EW, Diallo A, Oki J, Holden K, QCRG Structural Biology Consortium, Krogan N, Galonic Fujimori D, Ott M. bioRxiv. 2021 Nov 15.
- Identification of a therapeutic interfering particle-A single-dose SARS-CoV-2 antiviral intervention with a high barrier to resistance. Chaturvedi S, Vasen G, Pablo M, Chen X, Beutler N, Kumar A, Tanner E, Illouz S, Rahgoshay D, Burnett J, Holguin L, Chen PY, Ndjamen B, Ott M, Rodick R, Rogers T, Smith DM, Weinberger LS. Cell. 2021 12 09; 184(25):6022-6036.e18.
- Rapid assessment of SARS-CoV-2-evolved variants using virus-like particles. Syed AM, Taha TY, Tabata T, Chen IP, Ciling A, Khalid MM, Sreekumar B, Chen PY, Hayashi JM, Soczek KM, Ott M, Doudna JA. Science. 2021 Dec 24; 374(6575):1626-1632.
- Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases. Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, Díaz de León Derby M, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, Fozouni P, Shu J, Stephens SI, Kumar GR, Zhao C, Mok A, Iavarone AT, Escajeda AM, McIntosh R, Kim S, Dugan EJ, IGI Testing Consortium, Pollard KS, Tan MX, Ott M, Fletcher DA, Lareau LF, Hsu PD, Savage DF, Doudna JA. Nat Chem Biol. 2021 Nov; 17(11):1210.
- Accelerated RNA detection using tandem CRISPR nucleases. Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, Díaz de León Derby M, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, Fozouni P, Shu J, Stephens SI, Kumar GR, Zhao C, Mok A, Iavarone AT, Escajeda AM, McIntosh R, Kim S, Dugan EJ, IGI Testing Consortium, Pollard KS, Tan MX, Ott M, Fletcher DA, Lareau LF, Hsu PD, Savage DF, Doudna JA. Nat Chem Biol. 2021 09; 17(9):982-988.
- Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2. Biering SB, Van Dis E, Wehri E, Yamashiro LH, Nguyenla X, Dugast-Darzacq C, Graham TGW, Stroumza JR, Golovkine GR, Roberts AW, Fines DM, Spradlin JN, Ward CC, Bajaj T, Dovala D, Schulze-Gamen U, Bajaj R, Fox DM, Ott M, Murthy N, Nomura DK, Schaletzky J, Stanley SA. ACS Infect Dis. 2021 08 13; 7(8):2337-2351.
- Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19. Le BL, Andreoletti G, Oskotsky T, Vallejo-Gracia A, Rosales R, Yu K, Kosti I, Leon KE, Bunis DG, Li C, Kumar GR, White KM, García-Sastre A, Ott M, Sirota M. Sci Rep. 2021 06 10; 11(1):12310.
- SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator. Hysenaj L, Little S, Kulhanek K, Gbenedio OM, Rodriguez L, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Bahl K, Mick E, Li JZ, Ding VW, Matsumoto S, Maishan M, Simoneau C, Fragiadakis G, Jablons DM, Langelier CR, Matthay M, Ott M, Krummel M, Combes AJ, Sil A, Erle DJ, Kratz JR, Roose JP. bioRxiv. 2021 Jun 02.
- Sentinel cells enable genetic detection of SARS-CoV-2 Spike protein. Weinberg ZY, Hilburger CE, Kim M, Cao L, Khalid M, Elmes S, Diwanji D, Hernandez E, Lopez J, Schaefer K, Smith AM, Zhou F, QCRG Structural Biology Consortium, Renuka Kumar G, Ott M, Baker D, El-Samad H. bioRxiv. 2021 Apr 20.
- Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant. Deng X, Garcia-Knight MA, Khalid MM, Servellita V, Wang C, Morris MK, Sotomayor-González A, Glasner DR, Reyes KR, Gliwa AS, Reddy NP, Sanchez San Martin C, Federman S, Cheng J, Balcerek J, Taylor J, Streithorst JA, Miller S, Sreekumar B, Chen PY, Schulze-Gahmen U, Taha TY, Hayashi JM, Simoneau CR, Kumar GR, McMahon S, Lidsky PV, Xiao Y, Hemarajata P, Green NM, Espinosa A, Kath C, Haw M, Bell J, Hacker JK, Hanson C, Wadford DA, Anaya C, Ferguson D, Frankino PA, Shivram H, Lareau LF, Wyman SK, Ott M, Andino R, Chiu CY. Cell. 2021 06 24; 184(13):3426-3437.e8.
- Novel RT-ddPCR assays for measuring the levels of subgenomic and genomic SARS-CoV-2 transcripts. Telwatte S, Martin HA, Marczak R, Fozouni P, Vallejo-Gracia A, Kumar GR, Murray V, Lee S, Ott M, Wong JK, Yukl SA. Methods. 2022 05; 201:15-25.
- Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19. Le BL, Andreoletti G, Oskotsky T, Vallejo-Gracia A, Rosales R, Yu K, Kosti I, Leon KE, Bunis DG, Li C, Kumar GR, White KM, García-Sastre A, Ott M, Sirota M. Res Sq. 2021 Mar 30.
- Accelerated RNA detection using tandem CRISPR nucleases. Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, de León Derby MD, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, Fozouni P, Shu J, Stephens SI, Kumar GR, Zhao C, Mok A, Iavarone AT, Escajeda AM, McIntosh R, Kim SE, Dugan EJ, IGI Testing Consortium, Pollard KS, Tan MX, Ott M, Fletcher DA, Lareau LF, Hsu PD, Savage DF, Doudna JA. medRxiv. 2021 Mar 24.
- A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection. Kulsuptrakul J, Wang R, Meyers NL, Ott M, Puschnik AS. Cell Rep. 2021 03 16; 34(11):108859.
- SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19. Perez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Silva AC, Ramadoss GN, Flanigan WR, Fozouni P, Li H, Chen PY, Nakamura K, Whitman JD, Hanson PJ, McManus BM, Ott M, Conklin BR, McDevitt TC. Sci Transl Med. 2021 04 21; 13(590).
- Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation. Deng X, Garcia-Knight MA, Khalid MM, Servellita V, Wang C, Morris MK, Sotomayor-González A, Glasner DR, Reyes KR, Gliwa AS, Reddy NP, Martin CSS, Federman S, Cheng J, Balcerek J, Taylor J, Streithorst JA, Miller S, Kumar GR, Sreekumar B, Chen PY, Schulze-Gahmen U, Taha TY, Hayashi J, Simoneau CR, McMahon S, Lidsky PV, Xiao Y, Hemarajata P, Green NM, Espinosa A, Kath C, Haw M, Bell J, Hacker JK, Hanson C, Wadford DA, Anaya C, Ferguson D, Lareau LF, Frankino PA, Shivram H, Wyman SK, Ott M, Andino R, Chiu CY. medRxiv. 2021 Mar 09.
- Novel RT-ddPCR assays for simultaneous quantification of multiple noncoding and coding regions of SARS-CoV-2 RNA. Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA. J Virol Methods. 2021 06; 292:114115.
- Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo. Gramatica A, Schwarzer R, Brantley W, Varco-Merth B, Sperber HS, Hull PA, Montano M, Migueles SA, Rosenthal D, Hogan LE, Johnson JR, Packard TA, Grimmett ZW, Herzig E, Besnard E, Nekorchuk M, Hsiao F, Deeks SG, Snape M, Kiernan B, Roan NR, Lifson JD, Estes JD, Picker LJ, Verdin E, Krogan NJ, Henrich TJ, Connors M, Ott M, Pillai SK, Okoye AA, Greene WC. J Virol. 2021 Feb 03.
- Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes. Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Perez Y, Mostajo-Radji MA, Wang S, Velmeshev D, Salma J, Kumar GR, Pollen AA, Crouch EE, Ott M, Kriegstein AR. bioRxiv. 2021 Jan 18.
- Novel RT-ddPCR Assays for determining the transcriptional profile of SARS-CoV-2. Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA. bioRxiv. 2021 Jan 12.
- Author Correction: Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Nat Metab. 2021 Jan; 3(1):120-121.
- Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses. Wang R, Simoneau CR, Kulsuptrakul J, Bouhaddou M, Travisano KA, Hayashi JM, Carlson-Stevermer J, Zengel JR, Richards CM, Fozouni P, Oki J, Rodriguez L, Joehnk B, Walcott K, Holden K, Sil A, Carette JE, Krogan NJ, Ott M, Puschnik AS. Cell. 2021 01 07; 184(1):106-119.e14.
- Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy. Fozouni P, Son S, Díaz de León Derby M, Knott GJ, Gray CN, D'Ambrosio MV, Zhao C, Switz NA, Kumar GR, Stephens SI, Boehm D, Tsou CL, Shu J, Bhuiya A, Armstrong M, Harris AR, Chen PY, Osterloh JM, Meyer-Franke A, Joehnk B, Walcott K, Sil A, Langelier C, Pollard KS, Crawford ED, Puschnik AS, Phelps M, Kistler A, DeRisi JL, Doudna JA, Fletcher DA, Ott M. Cell. 2021 01 21; 184(2):323-333.e9.
- Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology. Simoneau CR, Ott M. Cell Stem Cell. 2020 12 03; 27(6):859-868.
- Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men. Samuel RM, Majd H, Richter MN, Ghazizadeh Z, Zekavat SM, Navickas A, Ramirez JT, Asgharian H, Simoneau CR, Bonser LR, Koh KD, Garcia-Knight M, Tassetto M, Sunshine S, Farahvashi S, Kalantari A, Liu W, Andino R, Zhao H, Natarajan P, Erle DJ, Ott M, Goodarzi H, Fattahi F. Cell Stem Cell. 2020 12 03; 27(6):876-889.e12.
- Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Nat Metab. 2020 11; 2(11):1265-1283.
- An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. Science. 2020 12 18; 370(6523):1473-1479.
- Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbølle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, QCRG Structural Biology Consortium, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, Zoonomia Consortium, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, Shokat KM, García-Sastre A, Rassen JA, Grosse R, Rosenberg OS, Verba KA, Basler CF, Vignuzzi M, Peden AA, Beltrao P, Krogan NJ. Science. 2020 12 04; 370(6521).
- SIRT1 is downregulated by autophagy in senescence and ageing. Xu C, Wang L, Fozouni P, Evjen G, Chandra V, Jiang J, Lu C, Nicastri M, Bretz C, Winkler JD, Amaravadi R, Garcia BA, Adams PD, Ott M, Tong W, Johansen T, Dou Z, Berger SL. Nat Cell Biol. 2020 10; 22(10):1170-1179.
- Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses. Wang R, Simoneau CR, Kulsuptrakul J, Bouhaddou M, Travisano K, Hayashi JM, Carlson-Stevermer J, Oki J, Holden K, Krogan NJ, Ott M, Puschnik AS. bioRxiv. 2020 Sep 24.
- SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients. Pérez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Ramadoss GN, Silva AC, Flanigan WR, Li H, Nakamura K, Whitman JD, Ott M, Conklin BR, McDevitt TC. bioRxiv. 2020 Sep 12.
- Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo. Miao Y, Ha A, de Lau W, Yuki K, Santos AJM, You C, Geurts MH, Puschhof J, Pleguezuelos-Manzano C, Peng WC, Senlice R, Piani C, Buikema JW, Gbenedio OM, Vallon M, Yuan J, de Haan S, Hemrika W, Rösch K, Dang LT, Baker D, Ott M, Depeille P, Wu SM, Drost J, Nusse R, Roose JP, Piehler J, Boj SF, Janda CY, Clevers H, Kuo CJ, Garcia KC. Cell Stem Cell. 2020 11 05; 27(5):840-851.e6.
- An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation. Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. bioRxiv. 2020 Aug 17.
- Turning up the heat on HIV-1. Chen IP, Ott M. Proc Natl Acad Sci U S A. 2020 07 14; 117(28):16109-16111.
- The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Bouhaddou M, Memon D, Meyer B, White KM, Rezelj VV, Correa Marrero M, Polacco BJ, Melnyk JE, Ulferts S, Kaake RM, Batra J, Richards AL, Stevenson E, Gordon DE, Rojc A, Obernier K, Fabius JM, Soucheray M, Miorin L, Moreno E, Koh C, Tran QD, Hardy A, Robinot R, Vallet T, Nilsson-Payant BE, Hernandez-Armenta C, Dunham A, Weigang S, Knerr J, Modak M, Quintero D, Zhou Y, Dugourd A, Valdeolivas A, Patil T, Li Q, Hüttenhain R, Cakir M, Muralidharan M, Kim M, Jang G, Tutuncuoglu B, Hiatt J, Guo JZ, Xu J, Bouhaddou S, Mathy CJP, Gaulton A, Manners EJ, Félix E, Shi Y, Goff M, Lim JK, McBride T, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, De Wit E, Leach AR, Kortemme T, Shoichet B, Ott M, Saez-Rodriguez J, tenOever BR, Mullins RD, Fischer ER, Kochs G, Grosse R, García-Sastre A, Vignuzzi M, Johnson JR, Shokat KM, Swaney DL, Beltrao P, Krogan NJ. Cell. 2020 08 06; 182(3):685-712.e19.
- An 'Arms Race' between the Nonsense-mediated mRNA Decay Pathway and Viral Infections. Leon K, Ott M. Semin Cell Dev Biol. 2021 03; 111:101-107.
- FOXO1 promotes HIV latency by suppressing ER stress in T cells. Vallejo-Gracia A, Chen IP, Perrone R, Besnard E, Boehm D, Battivelli E, Tezil T, Krey K, Raymond KA, Hull PA, Walter M, Habrylo I, Cruz A, Deeks S, Pillai S, Verdin E, Ott M. Nat Microbiol. 2020 09; 5(9):1144-1157.
- A combinatorial view of old and new RNA polymerase II modifications. Lyons DE, McMahon S, Ott M. Transcription. 2020 04; 11(2):66-82.
- A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. Nature. 2020 07; 583(7816):459-468.
- Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract. Khan S, Lew I, Wu F, Fritts L, Fontaine KA, Tomar S, Trapecar M, Shehata HM, Ott M, Miller CJ, Sanjabi S. Nat Commun. 2019 09 25; 10(1):4344.
- Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins. Ali I, Ruiz DG, Ni Z, Johnson JR, Zhang H, Li PC, Khalid MM, Conrad RJ, Guo X, Min J, Greenblatt J, Jacobson M, Krogan NJ, Ott M. Mol Cell. 2019 06 20; 74(6):1164-1174.e4.
- High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets. Schilling B, Meyer JG, Wei L, Ott M, Verdin E. Methods Mol Biol. 2019; 1983:3-16.
- A BAF'ling Approach to Curing HIV. Tomar S, Ali I, Ott M. Cell Chem Biol. 2018 12 20; 25(12):1441-1442.
- How cells hush a viral invader. Fozouni P, Ott M. Nature. 2018 12; 564(7735):193-194.
- The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein. Fontaine KA, Leon KE, Khalid MM, Tomar S, Jimenez-Morales D, Dunlap M, Kaye JA, Shah PS, Finkbeiner S, Krogan NJ, Ott M. mBio. 2018 11 06; 9(6).
- Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics. Ali I, Conrad RJ, Verdin E, Ott M. Chem Rev. 2018 02 14; 118(3):1216-1252.
- Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1. Jeng MY, Hull PA, Fei M, Kwon HS, Tsou CL, Kasler H, Ng CP, Gordon DE, Johnson J, Krogan N, Verdin E, Ott M. J Exp Med. 2018 01 02; 215(1):51-62.
- Host Methyltransferases and Demethylases: Potential New Epigenetic Targets for HIV Cure Strategies and Beyond. Boehm D, Ott M. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S8-S22.
- The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes. Conrad RJ, Fozouni P, Thomas S, Sy H, Zhang Q, Zhou MM, Ott M. Mol Cell. 2017 Sep 21; 67(6):1001-1012.e6.
- Flow Cytometric Analysis of HIV-1 Transcriptional Activity in Response to shRNA Knockdown in A2 and A72 J-Lat Cell Lines. Boehm D, Ott M. Bio Protoc. 2017 Jun 05; 7(11).
- Flow Cytometric Analysis of Drug-induced HIV-1 Transcriptional Activity in A2 and A72 J-Lat Cell Lines. Boehm D, Ott M. Bio Protoc. 2017 May 20; 7(10).
- SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency. Boehm D, Jeng M, Camus G, Gramatica A, Schwarzer R, Johnson JR, Hull PA, Montano M, Sakane N, Pagans S, Godin R, Deeks SG, Krogan NJ, Greene WC, Ott M. Cell Host Microbe. 2017 May 10; 21(5):569-579.e6.
- Retrovirus Integration: Some Assembly Required? Ali I, Conrad RJ, Ott M. Cell Host Microbe. 2016 Dec 14; 20(6):702-704.
- The mTOR Complex Controls HIV Latency. Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E. Cell Host Microbe. 2016 Dec 14; 20(6):785-797.
- Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication. Khan S, Woodruff EM, Trapecar M, Fontaine KA, Ezaki A, Borbet TC, Ott M, Sanjabi S. J Exp Med. 2016 12 12; 213(13):2913-2929.
- Asna1/TRC40 that mediates membrane insertion of tail-anchored proteins is required for efficient release of Herpes simplex virus 1 virions. Ott M, Marques D, Funk C, Bailer SM. Virol J. 2016 Oct 20; 13(1):175.
- International AIDS Society global scientific strategy: towards an HIV cure 2016. Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F, International AIDS Society Towards a Cure Working Group, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J. Nat Med. 2016 08; 22(8):839-50.
- Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity. Shirakawa K, Wang L, Man N, Maksimoska J, Sorum AW, Lim HW, Lee IS, Shimazu T, Newman JC, Schröder S, Ott M, Marmorstein R, Meier J, Nimer S, Verdin E. Elife. 2016 05 31; 5.
- Entangled in a membranous web: ER and lipid droplet reorganization during hepatitis C virus infection. Meyers NL, Fontaine KA, Kumar GR, Ott M. Curr Opin Cell Biol. 2016 08; 41:117-24.
- The HIV-1 Tat Protein Is Monomethylated at Lysine 71 by the Lysine Methyltransferase KMT7. Ali I, Ramage H, Boehm D, Dirk LM, Sakane N, Hanada K, Pagans S, Kaehlcke K, Aull K, Weinberger L, Trievel R, Schnoelzer M, Kamada M, Houtz R, Ott M. J Biol Chem. 2016 07 29; 291(31):16240-8.
- Therapeutics Targeting Protein Acetylation Perturb Latency of Human Viruses. Conrad RJ, Ott M. ACS Chem Biol. 2016 Mar 18; 11(3):669-80.
- Zinc supplementation induces regulatory T cells by inhibition of Sirt-1 deacetylase in mixed lymphocyte cultures. Rosenkranz E, Metz CH, Maywald M, Hilgers RD, Weßels I, Senff T, Haase H, Jäger M, Ott M, Aspinall R, Plümäkers B, Rink L. Mol Nutr Food Res. 2016 Mar; 60(3):661-71.
- Subcellular trafficking and functional importance of herpes simplex virus type 1 glycoprotein M domains. Striebinger H, Zhang J, Ott M, Funk C, Radtke K, Duron J, Ruzsics Z, Haas J, Lippé R, Bailer SM. J Gen Virol. 2015 Nov; 96(11):3313-3325.
- Manipulation of the host protein acetylation network by human immunodeficiency virus type 1. Jeng MY, Ali I, Ott M. Crit Rev Biochem Mol Biol. 2015; 50(4):314-25.
- The Herpes Simplex Virus Protein pUL31 Escorts Nucleocapsids to Sites of Nuclear Egress, a Process Coordinated by Its N-Terminal Domain. Funk C, Ott M, Raschbichler V, Nagel CH, Binz A, Sodeik B, Bauerfeind R, Bailer SM. PLoS Pathog. 2015 Jun; 11(6):e1004957.
- SIRT1 deacetylates RORγt and enhances Th17 cell generation. Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E. J Exp Med. 2015 Jun 01; 212(6):973.
- SIRT1 deacetylates RORγt and enhances Th17 cell generation. Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E. J Exp Med. 2015 May 04; 212(5):607-17.
- Membrane Flotation Assay. Vogt DA, Ott M. Bio Protoc. 2015 Apr 05; 5(7).
- Evolution of lysine acetylation in the RNA polymerase II C-terminal domain. Simonti CN, Pollard KS, Schröder S, He D, Bruneau BG, Ott M, Capra JA. BMC Evol Biol. 2015 Mar 10; 15:35.
- A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay. Ramage HR, Kumar GR, Verschueren E, Johnson JR, Von Dollen J, Johnson T, Newton B, Shah P, Horner J, Krogan NJ, Ott M. Mol Cell. 2015 Jan 22; 57(2):329-340.
- 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond. Verdin E, Ott M. Nat Rev Mol Cell Biol. 2015 04; 16(4):258-64.
- The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets. Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M. J Biol Chem. 2014 Dec 26; 289(52):35770-80.
- Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, Ott M. Mol Cell. 2013 Nov 07; 52(3):314-24.
- Evasion of superinfection exclusion and elimination of primary viral RNA by an adapted strain of hepatitis C virus. Webster B, Ott M, Greene WC. J Virol. 2013 Dec; 87(24):13354-69.
- Acetylphosphate: a novel link between lysine acetylation and intermediary metabolism in bacteria. Verdin E, Ott M. Mol Cell. 2013 Jul 25; 51(2):132-4.
- Bromodomain proteins in HIV infection. Boehm D, Conrad RJ, Ott M. Viruses. 2013 Jun 21; 5(6):1571-86.
- Three rules for HIV latency: location, location, and location. Ott M, Verdin E. Cell Host Microbe. 2013 Jun 12; 13(6):625-6.
- How the antiviral immune response boosts liver fat. Camus G, Ott M. Nat Med. 2013 Jun; 19(6):671-2.
- Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein. Vogt DA, Camus G, Herker E, Webster BR, Tsou CL, Greene WC, Yen TS, Ott M. PLoS Pathog. 2013; 9(4):e1003302.
- Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core. Camus G, Herker E, Modi AA, Haas JT, Ramage HR, Farese RV, Ott M. J Biol Chem. 2013 Apr 05; 288(14):9915-9923.
- Snapshots: chromatin control of viral infection. Knipe DM, Lieberman PM, Jung JU, McBride AA, Morris KV, Ott M, Margolis D, Nieto A, Nevels M, Parks RJ, Kristie TM. Virology. 2013 Jan 05; 435(1):141-56.
- Lipid droplets and viral infections. Camus G, Vogt DA, Kondratowicz AS, Ott M. Methods Cell Biol. 2013; 116:167-90.
- Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis. Webster B, Wissing S, Herker E, Ott M, Greene WC. J Virol. 2013 Jan; 87(1):581-96.
- Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. Kwon HS, Lim HW, Wu J, Schnölzer M, Verdin E, Ott M. J Immunol. 2012 Mar 15; 188(6):2712-21.
- BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Boehm D, Calvanese V, Dar RD, Xing S, Schroeder S, Martins L, Aull K, Li PC, Planelles V, Bradner JE, Zhou MM, Siliciano RF, Weinberger L, Verdin E, Ott M. Cell Cycle. 2013 Feb 01; 12(3):452-62.
- The control of HIV transcription: keeping RNA polymerase II on track. Ott M, Geyer M, Zhou Q. Cell Host Microbe. 2011 Nov 17; 10(5):426-35.
- Emerging role of lipid droplets in host/pathogen interactions. Herker E, Ott M. J Biol Chem. 2012 Jan 20; 287(4):2280-7.
- Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnölzer M, Verdin E, Zhou MM, Ott M. J Biol Chem. 2012 Jan 06; 287(2):1090-9.
- Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis. Harris C, Herker E, Farese RV, Ott M. J Biol Chem. 2011 Dec 09; 286(49):42615-42625.
- Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1). Sakane N, Kwon HS, Pagans S, Kaehlcke K, Mizusawa Y, Kamada M, Lassen KG, Chan J, Greene WC, Schnoelzer M, Ott M. PLoS Pathog. 2011 Aug; 7(8):e1002184.
- Functional characterization of the essential tail anchor of the herpes simplex virus type 1 nuclear egress protein pUL34. Ott M, Tascher G, Haßdenteufel S, Zimmermann R, Haas J, Bailer SM. J Gen Virol. 2011 Dec; 92(Pt 12):2734-2745.
- Unique ties between hepatitis C virus replication and intracellular lipids. Herker E, Ott M. Trends Endocrinol Metab. 2011 Jun; 22(6):241-8.
- HIV never ceases to surprise: Innovative methods in the quest for a cure. Ott M. Methods. 2011 Jan; 53(1):1-2.
- Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV, Ott M. Nat Med. 2010 Nov; 16(11):1295-8.
- Acetylation of tau inhibits its degradation and contributes to tauopathy. Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L. Neuron. 2010 Sep 23; 67(6):953-66.
- Characterization of HIV Tat modifications using novel methyl-lysine-specific antibodies. Pagans S, Sakane N, Schnölzer M, Ott M. Methods. 2011 Jan; 53(1):91-6.
- CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongation. Cho S, Schroeder S, Ott M. Cell Cycle. 2010 May; 9(9):1697-705.
- HAT trick: p300, small molecule, inhibitor. Ott M, Verdin E. Chem Biol. 2010 May 28; 17(5):417-8.
- The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Pagans S, Kauder SE, Kaehlcke K, Sakane N, Schroeder S, Dormeyer W, Trievel RC, Verdin E, Schnolzer M, Ott M. Cell Host Microbe. 2010 Mar 18; 7(3):234-44.
- Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells. Cho S, Schroeder S, Kaehlcke K, Kwon HS, Pedal A, Herker E, Schnoelzer M, Ott M. EMBO J. 2009 May 20; 28(10):1407-17.
- Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR. Ott M, Fricker G, Bauer B. J Pharmacol Exp Ther. 2009 Apr; 329(1):141-9.
- Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria. Nakamura K, Nemani VM, Wallender EK, Kaehlcke K, Ott M, Edwards RH. J Neurosci. 2008 Nov 19; 28(47):12305-17.
- The ups and downs of SIRT1. Kwon HS, Ott M. Trends Biochem Sci. 2008 Nov; 33(11):517-25.
- Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Kwon HS, Brent MM, Getachew R, Jayakumar P, Chen LF, Schnolzer M, McBurney MW, Marmorstein R, Greene WC, Ott M. Cell Host Microbe. 2008 Mar 13; 3(3):158-67.
- Recruitment and activation of RSK2 by HIV-1 Tat. Hetzer C, Bisgrove D, Cohen MS, Pedal A, Kaehlcke K, Speyerer A, Bartscherer K, Taunton J, Ott M. PLoS One. 2007 Jan 17; 2(1):e151.
- Hepatitis C and risk of lymphoma: results of the European multicenter case-control study EPILYMPH. Nieters A, Kallinowski B, Brennan P, Ott M, Maynadié M, Benavente Y, Foretova L, Cocco PL, Staines A, Vornanen M, Whitby D, Boffetta P, Becker N, De Sanjosé S. Gastroenterology. 2006 Dec; 131(6):1879-86.
- The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter. Mahmoudi T, Parra M, Vries RG, Kauder SE, Verrijzer CP, Ott M, Verdin E. J Biol Chem. 2006 Jul 21; 281(29):19960-8.
- Analysis of p300 acetyltransferase substrate specificity by MALDI TOF mass spectrometry. Dormeyer W, Ott M, Schnölzer M. Methods. 2005 Aug; 36(4):376-82.
- Decoding Tat: the biology of HIV Tat posttranslational modifications. Hetzer C, Dormeyer W, Schnölzer M, Ott M. Microbes Infect. 2005 Oct; 7(13):1364-9.
- Probing lysine acetylation in proteins: strategies, limitations, and pitfalls of in vitro acetyltransferase assays. Dormeyer W, Ott M, Schnölzer M. Mol Cell Proteomics. 2005 Sep; 4(9):1226-39.
- SIRT1 regulates HIV transcription via Tat deacetylation. Pagans S, Pedal A, North BJ, Kaehlcke K, Marshall BL, Dorr A, Hetzer-Egger C, Henklein P, Frye R, McBurney MW, Hruby H, Jung M, Verdin E, Ott M. PLoS Biol. 2005 Feb; 3(2):e41.
- Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. Schwer B, Ren S, Pietschmann T, Kartenbeck J, Kaehlcke K, Bartenschlager R, Yen TS, Ott M. J Virol. 2004 Aug; 78(15):7958-68.
- HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane. Witte V, Laffert B, Rosorius O, Lischka P, Blume K, Galler G, Stilper A, Willbold D, D'Aloja P, Sixt M, Kolanus J, Ott M, Kolanus W, Schuler G, Baur AS. Mol Cell. 2004 Jan 30; 13(2):179-90.
- Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation. Ott M, Dorr A, Hetzer-Egger C, Kaehlcke K, Schnolzer M, Henklein P, Cole P, Zhou MM, Verdin E. Novartis Found Symp. 2004; 259:182-93; discussion 193-6, 223-5.
- Acetylation of the HIV-1 Tat protein: an in vitro study. Dormeyer W, Dorr A, Ott M, Schnölzer M. Anal Bioanal Chem. 2003 Aug; 376(7):994-1005.
- Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Kaehlcke K, Dorr A, Hetzer-Egger C, Kiermer V, Henklein P, Schnoelzer M, Loret E, Cole PA, Verdin E, Ott M. Mol Cell. 2003 Jul; 12(1):167-76.
- Release and intercellular transfer of cell surface CD81 via microparticles. Fritzsching B, Schwer B, Kartenbeck J, Pedal A, Horejsi V, Ott M. J Immunol. 2002 Nov 15; 169(10):5531-7.
- The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. Schwer B, North BJ, Frye RA, Ott M, Verdin E. J Cell Biol. 2002 Aug 19; 158(4):647-57.
- Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. Dorr A, Kiermer V, Pedal A, Rackwitz HR, Henklein P, Schubert U, Zhou MM, Verdin E, Ott M. EMBO J. 2002 Jun 03; 21(11):2715-23.
- Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mujtaba S, He Y, Zeng L, Farooq A, Carlson JE, Ott M, Verdin E, Zhou MM. Mol Cell. 2002 Mar; 9(3):575-86.
Contact
Melanie Ott
Email
415.734.4807
Alia Aguilar
Administrative Assistant
Email
Lab Members
Gili Aviv, PhD
Collaborator
Daniela Boehm, PhD
Staff Research Scientist I
Irene Chen
Graduate Student
Patricia Defechereux, PhD
Scientific Project Manager
Parinaz Fozouni
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Robert Furler O'Brien, PhD
Visiting Scientist
Ronnie Gascon
Research Associate II
Ludivine Grzelak, PhD
Postdoctoral Scholar
Jennifer Hayashi, PhD
Scientist
Sachin Jajoo
Research Associate I
Mir Khalid, PhD
Scientist
Gabriella Kimmerly
Rotation Student
Renuka Kumar, PhD
Scientific Program Leader II
Kristoffer Leon
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Zichong Li, PhD
Research Scientist
Yusuke Matsui, MD, PhD
Scientist
Maria McCavitt-Malvido
Research Associate II
Mauricio Montano
Research Scientist
Rachel Padget, PhD
Postdoctoral Scholar
Ursula Schulze-Gahmen, PhD
Senior Staff Research Scientist
Camille Simoneau, PhD
Collaborator
Bharath Sreekumar, PhD
Postdoctoral Scholar
Stephanie Stephens
Research Associate II
Rahul Suryawanshi, PhD
Staff Research Scientist II
Taha Taha, PhD
Research Scientist
Chia-Lin Tsou, MS
Research Scientist
Francisco Zapatero Belinchon, PhD
Postdoctoral Scholar