Alex Marson’s research goal is to understand the genetic circuits that control the function of cells in the human immune system, especially T cells. Marson and colleagues have developed new tools to accomplish efficient genome engineering in primary human immune cells with CRISPR. With this technology scientists can now readily re-write specific sequences in human cells and interrogate the biological effects. These advances in genome editing will accelerate fundamental insights into how immune cells are "wired" and have potential to enhance the next generation of cell-based immunotherapies for cancer, infectious diseases, organ transplantation and autoimmune diseases.
Disease Areas
Autoimmune Diseases
Cancer Immunotherapies
HIV/AIDS
Infectious Diseases
Areas of Expertise
CRISPR Genome Engineering
Functional Genomics
Human Genetics
Immunology
Lab Focus
Developing new tools for efficient genome engineering in primary human immune cells.
Pursuing a comprehensive strategy to test how coding and non-coding genetic variation controls functional programs in the immune system.
Performing functional genetic studies of host-pathogen interactions in primary human immune cells.
Research Impact
Marson’s team is pioneering new CRISPR gene editing technologies that offer faster, cheaper and more precise ways to re-write DNA programs in human immune cells. With these tools, the lab is engineering cells to treat a wide range of diseases. They are designing programs to make cells that can recognize and eliminate cancer, cells that are resistant to infections like HIV, and cells that can reduce inflammation in autoimmune diseases like multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. Reprogrammed human immune cells are emerging as a new class of “living” medicines.
Related News
Professional Titles
Director, Gladstone-UCSF Institute of Genomic Immunology
Associate Professor, Medicine, UCSF
Bio
Alexander Marson, MD, PhD, is the director of the Gladstone-UCSF Institute of Genomic Immunology, a senior investigator at Gladstone Institutes, and an associate professor in the Departments of Medicine and Microbiology and Immunology at UCSF.
Marson is interested in how DNA controls the behavior of cells in the human immune system. He uses the power of CRISPR technology to genetically engineer cells to fight cancer, autoimmune diseases, and infectious diseases.
He completed his undergraduate studies at Harvard University, and earned an MPhil in biological sciences from Cambridge. He earned his PhD at Whitehead Institute at MIT, where he worked with mentors Rick Young and Rudolf Jaenisch on transcriptional control of regulatory T cells and embryonic stem cells.
After completing his MD at Harvard Medical School and an internship and residency at the Brigham and Women’s Hospital, Marson joined UCSF in 2012 to complete clinical work as an infectious diseases fellow. He started his lab as a Sandler Faculty Fellow, before joining the faculty at UCSF and becoming scientific director of biomedicine at the Innovative Genomics Institute. He is also a Chan Zuckerberg Biohub Investigator and member of the Parker Institute for Cancer Immunotherapy.
Honors and Awards
2019 American Society of Clinical Investigators (ASCI) Member
2016 NIH/NIDA Avenir New Innovator Award
2016 Burroughs Wellcome Foundation Career Award for Medical Scientists
2016 American Society of Clinical Investigators (ASCI) Young Physician-Scientist Award
2010 James Tolbert Shipley Prize for Excellence and Accomplishment in Research, Harvard
2009 Sigma Xi, MIT
Publications
- Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity. Baars MJD, Douma T, Simeonov DR, Myers DR, Kulhanek K, Banerjee S, Zwakenberg S, Baltissen MP, Amini M, de Roock S, van Wijk F, Vermeulen M, Marson A, Roose JP, Vercoulen Y. Eur J Immunol. 2020 Oct 16.
- Author Correction: Multiplexed droplet single-cell RNA-sequencing using natural genetic variation. Kang HM, Subramaniam M, Targ S, Nguyen M, Maliskova L, McCarthy E, Wan E, Wong S, Byrnes L, Lanata CM, Gate RE, Mostafavi S, Marson A, Zaitlen N, Criswell LA, Ye CJ. Nat Biotechnol. 2020 Oct 14.
- Functional CRISPR dissection of gene networks controlling human regulatory T cell identity. Schumann K, Raju SS, Lauber M, Kolb S, Shifrut E, Cortez JT, Skartsis N, Nguyen VQ, Woo JM, Roth TL, Yu R, Nguyen MLT, Simeonov DR, Nguyen DN, Targ S, Gate RE, Tang Q, Bluestone JA, Spitzer MH, Ye CJ, Marson A. Nat Immunol. 2020 Sep 28.
- Layilin augments integrin activation to promote antitumor immunity. Mahuron KM, Moreau JM, Glasgow JE, Boda DP, Pauli ML, Gouirand V, Panjabi L, Grewal R, Luber JM, Mathur AN, Feldman RM, Shifrut E, Mehta P, Lowe MM, Alvarado MD, Marson A, Singer M, Wells J, Jupp R, Daud AI, Rosenblum MD. J Exp Med. 2020 Sep 07; 217(9).
- NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting. Tan C, Hiwa R, Mueller JL, Vykunta V, Hibiya K, Noviski M, Huizar J, Brooks JF, Garcia J, Heyn C, Li Z, Marson A, Zikherman J. Nat Immunol. 2020 Oct; 21(10):1267-1279.
- Evaluation of SARS-CoV-2 serology assays reveals a range of test performance. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk RP, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. Nat Biotechnol. 2020 10; 38(10):1174-1183.
- Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR). Dong R, Libby KA, Blaeschke F, Fuchs W, Marson A, Vale RD, Su X. EMBO J. 2020 Aug 17; 39(16):e104730.
- Test performance evaluation of SARS-CoV-2 serological assays. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk R, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. medRxiv. 2020 May 17.
- CRISPR screen in regulatory T cells reveals modulators of Foxp3. Cortez JT, Montauti E, Shifrut E, Gatchalian J, Zhang Y, Shaked O, Xu Y, Roth TL, Simeonov DR, Zhang Y, Chen S, Li Z, Woo JM, Ho J, Vogel IA, Prator GY, Zhang B, Lee Y, Sun Z, Ifergan I, Van Gool F, Hargreaves DC, Bluestone JA, Marson A, Fang D. Nature. 2020 06; 582(7812):416-420.
- Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A. Cell. 2020 Apr 30; 181(3):728-744.e21.
- Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5a Binding to the Viral Core. Selyutina A, Persaud M, Simons LM, Bulnes-Ramos A, Buffone C, Martinez-Lopez A, Scoca V, Di Nunzio F, Hiatt J, Marson A, Krogan NJ, Hultquist JF, Diaz-Griffero F. Cell Rep. 2020 03 17; 30(11):3766-3777.e6.
- A Quantitative Genetic Interaction Map of HIV Infection. Gordon DE, Watson A, Roguev A, Zheng S, Jang GM, Kane J, Xu J, Guo JZ, Stevenson E, Swaney DL, Franks-Skiba K, Verschueren E, Shales M, Crosby DC, Frankel AD, Marson A, Marazzi I, Cagney G, Krogan NJ. Mol Cell. 2020 04 16; 78(2):197-209.e7.
- Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues. Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, Kim EA, Shin US, Krummel MF, Daud A, Scharschmidt TC, Rosenblum MD. JCI Insight. 2019 12 19; 4(24).
- Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency. Nguyen DN, Roth TL, Li PJ, Chen PA, Apathy R, Mamedov MR, Vo LT, Tobin VR, Goodman D, Shifrut E, Bluestone JA, Puck JM, Szoka FC, Marson A. Nat Biotechnol. 2020 01; 38(1):44-49.
- Helios enhances the preferential differentiation of human fetal CD4+ naïve T cells into regulatory T cells. Ng MSF, Roth TL, Mendoza VF, Marson A, Burt TD. Sci Immunol. 2019 11 22; 4(41).
- Landscape of stimulation-responsive chromatin across diverse human immune cells. Calderon D, Nguyen MLT, Mezger A, Kathiria A, Müller F, Nguyen V, Lescano N, Wu B, Trombetta J, Ribado JV, Knowles DA, Gao Z, Blaeschke F, Parent AV, Burt TD, Anderson MS, Criswell LA, Greenleaf WJ, Marson A, Pritchard JK. Nat Genet. 2019 10; 51(10):1494-1505.
- miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival. Gagnon JD, Kageyama R, Shehata HM, Fassett MS, Mar DJ, Wigton EJ, Johansson K, Litterman AJ, Odorizzi P, Simeonov D, Laidlaw BJ, Panduro M, Patel S, Jeker LT, Feeney ME, McManus MT, Marson A, Matloubian M, Sanjabi S, Ansel KM. Cell Rep. 2019 08 20; 28(8):2169-2181.e4.
- Large dataset enables prediction of repair after CRISPR-Cas9 editing in primary T cells. Leenay RT, Aghazadeh A, Hiatt J, Tse D, Roth TL, Apathy R, Shifrut E, Hultquist JF, Krogan N, Wu Z, Cirolia G, Canaj H, Leonetti MD, Marson A, May AP, Zou J. Nat Biotechnol. 2019 09; 37(9):1034-1037.
- ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. Hüttenhain R, Xu J, Burton LA, Gordon DE, Hultquist JF, Johnson JR, Satkamp L, Hiatt J, Rhee DY, Baek K, Crosby DC, Frankel AD, Marson A, Harper JW, Alpi AF, Schulman BA, Gross JD, Krogan NJ. . 2019 07 10; 26(1):86-99.e7.
- The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis. Mintz MA, Felce JH, Chou MY, Mayya V, Xu Y, Shui JW, An J, Li Z, Marson A, Okada T, Ware CF, Kronenberg M, Dustin ML, Cyster JG. Immunity. 2019 08 20; 51(2):310-323.e7.
- Orthotopic replacement of T-cell receptor a- and ß-chains with preservation of near-physiological T-cell function. Schober K, Müller TR, Gökmen F, Grassmann S, Effenberger M, Poltorak M, Stemberger C, Schumann K, Roth TL, Marson A, Busch DH. Nat Biomed Eng. 2019 12; 3(12):974-984.
- A large CRISPR-induced bystander mutation causes immune dysregulation. Simeonov DR, Brandt AJ, Chan AY, Cortez JT, Li Z, Woo JM, Lee Y, Carvalho CMB, Indart AC, Roth TL, Zou J, May AP, Lupski JR, Anderson MS, Buaas FW, Rokhsar DS, Marson A. Commun Biol. 2019; 2:70.
- CRISPR-Based Tools in Immunity. Simeonov DR, Marson A. Annu Rev Immunol. 2019 04 26; 37:571-597.
- A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells. Van Gool F, Nguyen MLT, Mumbach MR, Satpathy AT, Rosenthal WL, Giacometti S, Le DT, Liu W, Brusko TM, Anderson MS, Rudensky AY, Marson A, Chang HY, Bluestone JA. Immunity. 2019 02 19; 50(2):362-377.e6.
- Thymic regulatory T cells arise via two distinct developmental programs. Owen DL, Mahmud SA, Sjaastad LE, Williams JB, Spanier JA, Simeonov DR, Ruscher R, Huang W, Proekt I, Miller CN, Hekim C, Jeschke JC, Aggarwal P, Broeckel U, LaRue RS, Henzler CM, Alegre ML, Anderson MS, August A, Marson A, Zheng Y, Williams CB, Farrar MA. Nat Immunol. 2019 02; 20(2):195-205.
- CRISPR-Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV-host factor interactions. Hultquist JF, Hiatt J, Schumann K, McGregor MJ, Roth TL, Haas P, Doudna JA, Marson A, Krogan NJ. Nat Protoc. 2019 01; 14(1):1-27.
- Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function. Shifrut E, Carnevale J, Tobin V, Roth TL, Woo JM, Bui CT, Li PJ, Diolaiti ME, Ashworth A, Marson A. Cell. 2018 12 13; 175(7):1958-1971.e15.
- CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. Chen SH, Jang GM, Hüttenhain R, Gordon DE, Du D, Newton BW, Johnson JR, Hiatt J, Hultquist JF, Johnson TL, Liu YL, Burton LA, Ye J, Reichermeier KM, Stroud RM, Marson A, Debnath J, Gross JD, Krogan NJ. EMBO J. 2018 09 14; 37(18).
- Reprogramming human T cell function and specificity with non-viral genome targeting. Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta-Aranburu G, Del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros RM, Gurumurthy CB, Smith B, Haugwitz M, Hughes SH, Weissman JS, Schumann K, Esensten JH, May AP, Ashworth A, Kupfer GM, Greeley SAW, Bacchetta R, Meffre E, Roncarolo MG, Romberg N, Herold KC, Ribas A, Leonetti MD, Marson A. Nature. 2018 07; 559(7714):405-409.
- Revisiting IL-2: Biology and therapeutic prospects. Abbas AK, Trotta E, R Simeonov D, Marson A, Bluestone JA. Sci Immunol. 2018 07 06; 3(25).
- Author Correction: Discovery of stimulation-responsive immune enhancers with CRISPR activation. Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A. Nature. 2018 07; 559(7715):E13.
- Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms. Farboud B, Jarvis E, Roth TL, Shin J, Corn JE, Marson A, Meyer BJ, Patel NH, Hochstrasser ML. J Vis Exp. 2018 05 25; (135).
- Light-activated cell identification and sorting (LACIS) for selection of edited clones on a nanofluidic device. Mocciaro A, Roth TL, Bennett HM, Soumillon M, Shah A, Hiatt J, Chapman K, Marson A, Lavieu G. Commun Biol. 2018; 1:41.
- Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins. Wu CM, Roth TL, Baglaenko Y, Ferri DM, Brauer P, Zuniga-Pflucker JC, Rosbe KW, Wither JE, Marson A, Allen CDC. J Immunol Methods. 2018 06; 457:33-40.
- Multiplexed droplet single-cell RNA-sequencing using natural genetic variation. Kang HM, Subramaniam M, Targ S, Nguyen M, Maliskova L, McCarthy E, Wan E, Wong S, Byrnes L, Lanata CM, Gate RE, Mostafavi S, Marson A, Zaitlen N, Criswell LA, Ye CJ. Nat Biotechnol. 2018 01; 36(1):89-94.
- Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements. Mumbach MR, Satpathy AT, Boyle EA, Dai C, Gowen BG, Cho SW, Nguyen ML, Rubin AJ, Granja JM, Kazane KR, Wei Y, Nguyen T, Greenside PG, Corces MR, Tycko J, Simeonov DR, Suliman N, Li R, Xu J, Flynn RA, Kundaje A, Khavari PA, Marson A, Corn JE, Quertermous T, Greenleaf WJ, Chang HY. Nat Genet. 2017 Nov; 49(11):1602-1612.
- "T-bet"-ing on autoimmunity variants. Nguyen MLT, Simeonov DR, Marson A. PLoS Genet. 2017 09; 13(9):e1006924.
- Discovery of stimulation-responsive immune enhancers with CRISPR activation. Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A. Nature. 2017 09 07; 549(7670):111-115.
- CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim WA, Marson A. Sci Rep. 2017 04 07; 7(1):737.
- A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H, Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, Hacohen N, Walker BD. Nat Genet. 2017 Feb; 49(2):193-203.
- A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells. Hultquist JF, Schumann K, Woo JM, Manganaro L, McGregor MJ, Doudna J, Simon V, Krogan NJ, Marson A. Cell Rep. 2016 10 25; 17(5):1438-1452.
- A tissue checkpoint regulates type 2 immunity. Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM. Nat Immunol. 2016 Dec; 17(12):1381-1387.
- Generation of knock-in primary human T cells using Cas9 ribonucleoproteins. Schumann K, Lin S, Boyer E, Simeonov DR, Subramaniam M, Gate RE, Haliburton GE, Ye CJ, Bluestone JA, Doudna JA, Marson A. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10437-42.
- Genetic basis of autoimmunity. Marson A, Housley WJ, Hafler DA. J Clin Invest. 2015 Jun; 125(6):2234-41.
- The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation. DuPage M, Chopra G, Quiros J, Rosenthal WL, Morar MM, Holohan D, Zhang R, Turka L, Marson A, Bluestone JA. Immunity. 2015 Feb 17; 42(2):227-238.
- Genetic and epigenetic fine mapping of causal autoimmune disease variants. Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE. Nature. 2015 Feb 19; 518(7539):337-43.
- Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA. J Clin Invest. 2014 Jun; 124(6):2513-22.
- Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A, Kuchroo VK. Immunity. 2014 Apr 17; 40(4):477-89.
- Successful medical management of a Nocardia farcinica multiloculated pontine abscess. Chow FC, Marson A, Liu C. BMJ Case Rep. 2013 Dec 05; 2013.
- Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen. Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom DT, Odajima J, Geng Y, Zagozdzon A, Jecrois M, Young RA, Liu XS, Cepko CL, Gygi SP, Sicinski P. Nature. 2010 Jan 21; 463(7279):374-8.
- Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Marson A, Levine SS, Cole MF, Frampton GM, Brambrink T, Johnstone S, Guenther MG, Johnston WK, Wernig M, Newman J, Calabrese JM, Dennis LM, Volkert TL, Gupta S, Love J, Hannett N, Sharp PA, Bartel DP, Jaenisch R, Young RA. Cell. 2008 Aug 08; 134(3):521-33.
- Wnt signaling promotes reprogramming of somatic cells to pluripotency. Marson A, Foreman R, Chevalier B, Bilodeau S, Kahn M, Young RA, Jaenisch R. Cell Stem Cell. 2008 Aug 07; 3(2):132-5.
- Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Marson A, Kretschmer K, Frampton GM, Jacobsen ES, Polansky JK, MacIsaac KD, Levine SS, Fraenkel E, von Boehmer H, Young RA. Nature. 2007 Feb 22; 445(7130):931-5.
- PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein. Daniels MJ, Marson A, Venkitaraman AR. Nat Struct Mol Biol. 2004 Nov; 11(11):1114-21.
- Levetiracetam, oxcarbazepine, remacemide and zonisamide for drug resistant localization-related epilepsy: a systematic review. Marson AG, Hutton JL, Leach JP, Castillo S, Schmidt D, White S, Chaisewikul R, Privitera M, Chadwick DW. Epilepsy Res. 2001 Sep; 46(3):259-70.
Contact
Alex Marson
415.734.4861
Jackie Sawin
Executive Assistant
415.730.3797
Lab Members
Sagar Bapat, MD, PhD
Clinical Fellow
Franziska Blaeschke, MD
Scientist
Daniel Carr
Research Associate I
Yan Yi Chen
Research Associate I
Amy Peixin Chen
Research Associate II
Jessica Cortez
Graduate Student
Veronica Cruz
Research Assistant
Vigneshwari Easwar Kumar, MS
Research Associate II
Dana Foss, PhD
Affiliate
Jacob Freimer, PhD
Visiting Postdoc
Christian Garrido, MS
Research Associate III
Joseph Hiatt
Graduate Student
Patrick Hsu, PhD
Affiliate
Joy Jin
Graduate Student
Madeline Layeghi
Research Associate I
Youjin Lee, PhD
Scientist
Zhongmei Li, MS
Affiliate
Mitchell Lipke
Research Associate II
Murad Mamedov, PhD
Scientist
Edward Marsh, PhD
Postdoctoral Scholar
Cody Mowery
Graduate Student
David Nguyen, MD, PhD
Visiting Scientist
Jennifer Okano
Affiliate
Ujjwal Rathore, PhD
Scientist
Bruce Schaar, PhD
Scientific Project Manager
Ralf Schmidt, PhD
Scientist
Eric Shifrut, PhD
Scientist
Brian Shy, MD, PhD
Clinical Fellow
Zachary Steinhart, PhD
Postdoctoral Scholar
Jenny Umhoefer
Graduate Student
Shane Vedova
Research Associate I
Vivasvan Vykunta
Research Associate I
Carl Ward, PhD
Postdoctoral Scholar
Caroline Whitty
Research Associate II
Jon Woo
Affiliate
Tori Yamamoto, PhD
Postdoctoral Scholar
Ruby Yu, PhD
Scientist