News

Article May 29, 2024

CRISPR-Based Mapping Uncovers ‘Switches’ for Immune Genes Central to Health

A new study in Nature Genetics expands our understanding of immune regulation and autoimmunity—with findings that could also be used in the development of cancer immunotherapies.

News Release Autoimmune Diseases Cancer Genomic Immunology Parker Institute for Cancer Immunotherapy Marson Lab Pollard Lab Ye Lab AI CRISPR/Gene Editing

Gladstone in the News February 12, 2024

Using Cancer’s ’Superpower’ to Boost T-cell Therapies in Mice

Fierce Biotech—A naturally occurring mutation in T cells that leads to lymphoma can be weaponized to make engineered T-cell therapies more effective against cancer, including melanoma, findings from a new study in mice suggest. The study’s co-leads, dermatologist Jaehyuk Choi and scientist Kole Roybal, have launched a new biotech company called Moonlight Bio to take their findings to the clinic.

Research (Publication) Cancer Genomic Immunology Parker Institute for Cancer Immunotherapy Roybal Lab Genomics

Gladstone in the News February 7, 2024

Turbocharged CAR-T Cells Melt Tumours in Mice—Using a Trick from Cancer Cells

Nature—Cancer cells are the ultimate survivors, riddled with mutations that let them thrive when healthy cells would die. These same mutations can boost the ability of game-changing cell therapies to quash cancer, a study in mice shows. “Natural T-cell function isn’t good enough. We need to explore the extremes of T-cell function,” says Kole Roybal, co-author of the new paper.

Research (Publication) Cancer Genomic Immunology Parker Institute for Cancer Immunotherapy Roybal Lab Genomics

Article February 7, 2024

Scientists Use Cancer’s Strength to Fight Against It

In a new study that appears in Nature, researchers leveraged the power of a naturally occurring mutation in cancerous T cells to create a more powerful immunotherapy

News Release Research (Publication) Cancer Genomic Immunology Parker Institute for Cancer Immunotherapy Roybal Lab

Gladstone in the News October 3, 2023

New Paper Points the Way to Make CRISPR Safer by Avoiding Chromosome Loss

Innovative Genomics Institute—Gladstone Senior Investigator Jennifer Doudna and Affiliate Investigator Jimmie Ye, along with collaborators at the Parker Institute for Cancer Immunology and Stanford, have discovered a way to increase the safety of CRISPR editing by preventing chromosome loss, a toxic side-effect of the technology in some cells.

Gladstone Experts Cancer Data Science and Biotechnology Parker Institute for Cancer Immunotherapy Doudna Lab Ye Lab CRISPR/Gene Editing