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CRISPR-Based Mapping Uncovers ‘Switches’ for Immune Genes Central to Health

Marson Lab
Article May 29, 2024

CRISPR-Based Mapping Uncovers ‘Switches’ for Immune Genes Central to Health

A new study in Nature Genetics expands our understanding of immune regulation and autoimmunity—with findings that could also be used in the development of cancer immunotherapies.

News Release Autoimmune Diseases Cancer Genomic Immunology Parker Institute for Cancer Immunotherapy Marson Lab Pollard Lab Ye Lab AI CRISPR/Gene Editing

Advancing CRISPR Applications: Here, There and Everywhere

Gladstone in the News January 16, 2024

Advancing CRISPR Applications: Here, There and Everywhere

BioTechniques—Researchers at Gladstone Institutes have mapped the human immune response using next-generation CRISPR technology known as base editing. Using this tool, the team was able to identify specific nucleotides within T cells that influence immune cells’ response to stimuli, creating maps of DNA sequences and protein sites that are involved in human immune responses. The discoveries this project has facilitated could improve existing immunotherapies and reveal new drug targets for autoimmune diseases and cancer.

Research (Publication) Autoimmune Diseases Cancer Genomic Immunology Doudna Lab Marson Lab CRISPR/Gene Editing Genomics

Using Next-Gen CRISPR Tool, Gladstone Scientists Create Unprecedented Molecular Map of Human Immune Response

Carl Ward, a Gladstone postdoctoral associate, speaks with a student intern in the Marson Lab.
Article December 13, 2023

Using Next-Gen CRISPR Tool, Gladstone Scientists Create Unprecedented Molecular Map of Human Immune Response

The new study from the Marson Lab represents a major stride for human genetics; findings will accelerate the development of new and better therapies for cancer and autoimmune diseases.

News Release Research (Publication) Autoimmune Diseases Cancer Genomic Immunology Marson Lab Basic Science CRISPR/Gene Editing Genomics Human Genetics

You’re Missing Microbes. But Is “Rewilding” the Way to Get Them Back?

Gladstone in the News July 19, 2021

You’re Missing Microbes. But Is “Rewilding” the Way to Get Them Back?

New York Times—The microbiome plays a role in many autoimmune conditions, and some scientists believe that fecal transplants from individuals living in non-industrialized cultures may provide a solution. Katie Pollard, director of the Gladstone Institute of Data Science and Biotechnology, explains why it may not be that easy.

Gladstone Experts Autoimmune Diseases Data Science and Biotechnology Pollard Lab Microbiome

Genetic Network that Differentiates Regulatory T Cells Mapped

Gladstone in the News October 2, 2020

Genetic Network that Differentiates Regulatory T Cells Mapped

Clinical Omics—Alex Marson, MD, PhD, director of the Gladstone-UCSF Institute of Genomic Immunology, explains his lab's recent discovery of the the gene networks that distinguish regulatory T cells from other types of T cells, and the implication for therapies against cancer and autoimmune diseases.

Gladstone Experts Autoimmune Diseases Marson Lab

Immune System Gene Braking Discovery Opens Doors to New Cancer Therapies

Gladstone in the News October 1, 2020

Immune System Gene Braking Discovery Opens Doors to New Cancer Therapies

Genetic Engineering and Biotechnology News—Alex Marson, MD, PhD, director of the Gladstone-UCSF Institute of Genomic Immunology, explains the implications of his lab's recent identification of gene networks that control the function of immune cells, known as regulatory T cells, for therapies against cancer and autoimmune diseases.

Gladstone Experts Autoimmune Diseases Genomic Immunology Marson Lab

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