Gladstone NOW: The Campaign Join Us on the Journey ✕
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For National DNA Day, discover how Gladstone scientists are utilizing the power of DNA to deepen our understanding of disease.
Gladstone Experts Genomic Immunology Data Science and Biotechnology Marson Lab Pollard Lab Ramani Lab Shipman Lab Tcheandjieu Lab Big Data CRISPR/Gene Editing
Chan Zuckerberg Initiative—Alex Marson, director of the Gladstone-UCSF Institute of Genomic Immunology, explains that the Billion Cells Project, for which he is a collaborator, will provide a roadmap to guide drug development and identify targets to restore diseased cells to health.
Gladstone Experts Genomic Immunology Marson Lab
Scientists at Gladstone and UCSF discover how one protein controls the behavior of immune cells, with potential applications for treating cancer and autoimmune conditions.
News Release Research (Publication) Autoimmune Diseases Cancer Genomic Immunology Krogan Lab Marson Lab CRISPR/Gene Editing
Drug Discovery World—Alex Marson, director of the Gladstone-UCSF Institute of Genomic Immunology, is featured for his innovative work using CRISPR genome editing to develop better cellular therapies for cancer, silencing genes that cause immune cells to become exhausted and activating genes that help them be more effective.
Gladstone Experts Cancer Genomic Immunology Marson Lab CRISPR/Gene Editing
A new study in Nature Genetics expands our understanding of immune regulation and autoimmunity—with findings that could also be used in the development of cancer immunotherapies.
News Release Autoimmune Diseases Cancer Genomic Immunology Parker Institute for Cancer Immunotherapy Marson Lab Pollard Lab Ye Lab AI CRISPR/Gene Editing
The health and science publication STAT has selected a breakthrough discovery from Gladstone to be part of its annual STAT Madness competition, in which research institutes compete for the title of champion. The winner is deemed the most innovative research institution in the country.
Research (Publication) Cancer Genomic Immunology Doudna Lab CRISPR/Gene Editing
Fierce Biotech—A naturally occurring mutation in T cells that leads to lymphoma can be weaponized to make engineered T-cell therapies more effective against cancer, including melanoma, findings from a new study in mice suggest. The study’s co-leads, dermatologist Jaehyuk Choi and scientist Kole Roybal, have launched a new biotech company called Moonlight Bio to take their findings to the clinic.
Research (Publication) Cancer Genomic Immunology Parker Institute for Cancer Immunotherapy Roybal Lab Genomics
Nature—Cancer cells are the ultimate survivors, riddled with mutations that let them thrive when healthy cells would die. These same mutations can boost the ability of game-changing cell therapies to quash cancer, a study in mice shows. “Natural T-cell function isn’t good enough. We need to explore the extremes of T-cell function,” says Kole Roybal, co-author of the new paper.
Research (Publication) Cancer Genomic Immunology Parker Institute for Cancer Immunotherapy Roybal Lab Genomics
In a new study that appears in Nature, researchers leveraged the power of a naturally occurring mutation in cancerous T cells to create a more powerful immunotherapy
News Release Research (Publication) Cancer Genomic Immunology Parker Institute for Cancer Immunotherapy Roybal Lab
BioTechniques—Researchers at Gladstone Institutes have mapped the human immune response using next-generation CRISPR technology known as base editing. Using this tool, the team was able to identify specific nucleotides within T cells that influence immune cells’ response to stimuli, creating maps of DNA sequences and protein sites that are involved in human immune responses. The discoveries this project has facilitated could improve existing immunotherapies and reveal new drug targets for autoimmune diseases and cancer.
Research (Publication) Autoimmune Diseases Cancer Genomic Immunology Doudna Lab Marson Lab CRISPR/Gene Editing Genomics
The new study from the Marson Lab represents a major stride for human genetics; findings will accelerate the development of new and better therapies for cancer and autoimmune diseases.
News Release Research (Publication) Autoimmune Diseases Cancer Genomic Immunology Marson Lab Basic Science CRISPR/Gene Editing Genomics Human Genetics
Genetic Engineering & Biotechnology News—Scientists at the Gladstone Institutes have published a paper in Cell Reports that describes a CRISPR-based technique for treating primary glioblastoma, a common and aggressive form of brain cancer. The paper, titled “Targeting the non-coding genome and temozolomide signature enables CRISPR-mediated glioma oncolysis,” describes the technique, which the researchers have called “genome shredding.”
Research (Publication) Cancer Genomic Immunology Doudna Lab CRISPR/Gene Editing
This distinction recognizes his and the institute’s pioneering blend of genomics and immunology toward the design and improvement of cancer immunotherapy
Institutional News Genomic Immunology Marson Lab
PharmaVoice—PharmaVoice recently assembled its annual list of inspiring leaders in the industry. Alex Marson, director of the Gladstone-UCSF Institute of Genomic Immunology, was named to the list as a cancer care visionary, recognized for both his scientific innovation and his dedication to collaboration and mentoring.
Gladstone Experts Genomic Immunology Marson Lab
UCSF News—Gladstone Senior Investigators Alex Marson and Jennifer Doudna, and President of the UC San Francisco Helen Diller Family Comprehensive Cancer Center Alan Ashworth, will head the newly launched CRISPR Cures for Cancer Initiative, which will fund research at the intersection of genomic technologies and cellular immunotherapies at Gladstone Institutes, UC San Francisco, and the Innovative Genomics Institute at UC Berkeley.
Gladstone Experts Cancer Data Science and Biotechnology Genomic Immunology Doudna Lab Marson Lab CRISPR/Gene Editing Stem Cells/iPSCs
