Gladstone in the News
August 28, 2024
Chemical & Engineering News—In a new study, scientists in Jennifer Doudna’s lab probe how viruses interfere with host signaling. Postdoctoral Fellow Jason Nomburg explains how they assembled a database of predicted structures of viral proteins, and used it to find the functions of previously mysterious proteins.
Gladstone Experts
Virology
Doudna Lab
Article
March 1, 2024
The health and science publication STAT has selected a breakthrough discovery from Gladstone to be part of its annual STAT Madness competition, in which research institutes compete for the title of champion. The winner is deemed the most innovative research institution in the country.
Research (Publication)
Cancer
Genomic Immunology
Doudna Lab
CRISPR/Gene Editing
Gladstone in the News
January 16, 2024
BioTechniques—Researchers at Gladstone Institutes have mapped the human immune response using next-generation CRISPR technology known as base editing. Using this tool, the team was able to identify specific nucleotides within T cells that influence immune cells’ response to stimuli, creating maps of DNA sequences and protein sites that are involved in human immune responses. The discoveries this project has facilitated could improve existing immunotherapies and reveal new drug targets for autoimmune diseases and cancer.
Research (Publication)
Autoimmune Diseases
Cancer
Genomic Immunology
Doudna Lab
Marson Lab
CRISPR/Gene Editing
Genomics
Gladstone in the News
November 28, 2023
Genetic Engineering & Biotechnology News—Scientists at the Gladstone Institutes have published a paper in Cell Reports that describes a CRISPR-based technique for treating primary glioblastoma, a common and aggressive form of brain cancer. The paper, titled “Targeting the non-coding genome and temozolomide signature enables CRISPR-mediated glioma oncolysis,” describes the technique, which the researchers have called “genome shredding.”
Research (Publication)
Cancer
Genomic Immunology
Doudna Lab
CRISPR/Gene Editing
Gladstone in the News
July 25, 2022
The Daily Californian—Senior Investigator Melanie Ott, MD, PhD, and collaborator Abdullah Syed, PhD, a postdoctoral fellow in the laboratory of Senior Investigator Jennifer Doudna, explain how they discovered that antibodies against early versions of the SARS-CoV-2 virus do not protect well against the now widespread and highly contagious Omicron variant, and recommend masking to avoid new infections.
Gladstone Experts
COVID-19
Data Science and Biotechnology
Virology
Doudna Lab
Ott Lab
