Celebrate 30 Years of Discovery
For 30 years, the lab of Deepak Srivastava has advanced discoveries in congenital heart disease, cardiac development, and heart regeneration while training and mentoring a remarkable community of scientists and physicians. Many have gone on to lead research programs around the world, building on the ideas and collaborations that began in the Srivastava Lab.
To celebrate this milestone, join former trainees, collaborators, and current lab members for a day of science talks and conversation. Speakers will share new research spanning cardiac biology and genomics, as well as emerging approaches including artificial intelligence.
Beyond the science, the event is an opportunity to reconnect with colleagues and mentors who have been part of the Srivastava Lab over the past three decades.
Program
| 8:15am | Continental Breakfast |
| 8:30am | Welcome and Introduction Deepak Srivastava, MD | President, Gladstone Institutes |
| 8:55am | Basic and Clinical Science for Congenital Cardiac Outflow Defects Hiroyuki Yamagishi, MD, PhD | Keio University School of Medicine |
| 9:10am | Unraveling the Etiology of Congenital Heart Defects: Insights from Human Genetics and Mouse Models Vidu Garg, MD | Nationwide Children’s Hospital |
| 9:25am | Developmental Mechanisms Underlying Congenital Heart Defects Irfan Kathiriya, MD, PhD | UC San Francisco |
| 9:40am | Harnessing Small Molecules in Support of Organ Regeneration and Repair Ildiko Bock-Marquette, MD | University of Pecs Medical School |
| 9:55am | Making Adult Cardiomyocytes Chulan Kwon, PhD | Johns Hopkins University School of Medicine |
| 10:10am | 'Sniffing’ Out Alzheimer's Disease: Mechanisms of Olfactory Neurodegeneration Ankur Saxena, PhD | University of Alabama, Birmingham |
| 10:25am | Break |
| 10:45am | A General Framework for Understanding Tissue Repair and Fibrosis Yong Zhao, MD, PhD | Fuwai Henan Hospital, Chinese Academy of Medical Sciences |
| 11:00am | Role of Adventitial Fibroblast in Atherosclerosis Paul Cheng, MD, PhD | Stanford University School of Medicine |
| 11:15am | Origin of the Vertebrate Heartbeat Vasanth Vedantham, MD, PhD | UC San Francisco |
| 11:30am | Panel Discussion Yen-Sin Ang, PhD | Kopio Bio Emily Berry, PhD | California State Senate Kim Cordes Metzler, PhD | Just-Evotec Biologics Yvanka de Soysa, PhD | Foreground Capital Aryé Elfenbein, MD, PhD | Wildtype Aruna Natarajan, MD, PhD | Georgetown University Mark White, PhD | A-Alpha Bio |
| 12:00pm | Lunch |
| 1:00pm | Genetic Influences on Neurodevelopment in Congenital Heart Disease Sarah Morton, MD, PhD | Harvard Medical School |
| 1:15pm | Direct Reprogramming and Regenerative Medicine Masaki Ieda, MD, PhD | Keio University School of Medicine |
| 1:30pm | Decoding and Redirecting Cell Fate for Heart Repair Li Qian, PhD | University of North Carolina, Chapel Hill |
| 1:45pm | Two Sides of the Same Heart: Regeneration and Cardiac Safety Tamer Mohamed, PhD | Baylor College of Medicine |
| 2:00pm | 10 Years Advancing Cardiac Therapies at Tenaya Therapeutics Kathy Ivey, PhD | Tenaya Therapeutics |
| 2:15pm | Novel Noncanonical Functions of Noncoding RNAs in the Heart Jidong Fu, PhD | Ohio State University |
| 2:30pm | Group Photo and Break |
| 2:50pm | Foundational AI Models for Network Biology Christina Theodoris, MD, PhD | Gladstone Institutes |
| 3:05pm | Deep Learning Models Unbiasedly Discover Complex Motif Syntax Employed During Cardiac Differentiation Casey Gifford, PhD | Stanford University School of Medicine |
| 3:20pm | Chromatin Regulation of Cell States in Heart Disease Michael Alexanian, PhD | Gladstone Institutes |
| 3:35pm | Linking Trisomy 21 to Craniofacial Congenital Disorders Sanjeev Ranade, PhD | Sanford Burnham Prebys Institute |
| 3:50pm | Metabolic Rewiring Drives Maladaptive Epigenetic Memory in Macrophages, Promoting Recurrent Heart Failure Tomohiro Nishino, MD, PhD | Kyoto University |
| 4:05pm | Lab Skit |
About Srivastava Lab
The lab of Deepak Srivastava, MD, began in 1996 at University of Texas Southwestern Medical Center in Dallas, where Srivastava was a professor in the Department of Pediatrics and Molecular Biology. He moved his research group to San Francisco in 2005 to lead the Gladstone Institute of Cardiovascular Disease. Since its founding, the lab has mentored more than 100 trainees, many of whom have gone on to become leaders in their respective fields.
The Srivastava Lab is focused on the gene networks that guide the development of the heart, seeking to understand how aberrations in these pathways can cause congenital heart disease, and how they can use this knowledge to generate new cardiac cells to repair heart damage. One powerful approach they use is creating models of heart disease in a dish by reprogramming human cells from patients carrying mutations in cardiac developmental genes, editing them with CRISPR technology and analyzing changes at the single cell level. This has led them to discover perturbations in pivotal genetic pathways that contribute to disease, and identified the nodes that can be therapeutically targeted to restore heart cells to normal function.
Deepak Srivastava, MD, is president of Gladstone Institutes. He is also the Robert and Linda Mahley Distinguished Professor and a senior investigator at the Gladstone Institute of Cardiovascular Disease, and director of the Roddenberry Stem Cell Center. At UC San Francisco, Srivastava is a professor in the Departments of Pediatrics and Biochemistry and Biophysics, and is the Wilma and Adeline Pirag Distinguished Professor in pediatric developmental cardiology.
Details
Diversity, Equity, and Inclusion
At Gladstone, we are committed to providing events and professional development activities that resonate with our community’s diverse members. Our goal is to develop creative programming that encompasses a wide variety of ideas and perspectives to inspire, educate, and engage with everyone within our walls.
We want to effect positive change through our events and activities by providing a platform for discussions on important topics related to increasing diversity and inclusiveness in the sciences.