Nevan Krogan uses large-scale genetics and biochemistry to define the interactions among genes and proteins that govern cell functions in health and disease. Combining bench work with computer science, his lab identifies molecular networks acting inside cells and shows how these networks respond to disease-causing mutations or infection by pathogens. Thanks to their ability to survey a cell’s complete set of genes and proteins, Krogan and his team generate novel mechanistic insights into cell biology as well as potential targets for novel therapies. Krogan’s lab is applying this unbiased approach to a number of conditions, including infectious diseases such as COVID-19, cancer and heart disease.

Disease Areas

Infectious Diseases
Cancer
Heart Disease
Tauopathies
Pain
Psychiatric and Neurodevelopmental Disorders

Areas of Expertise

Proteomics
Functional Genomics
Computational Analysis
Systems Biology
Working in the Krogan lab

Lab Focus

Understanding how biological networks change in response to a variety of conditions, including stress, genetic mutations, drug treatment or infection by pathogens.
Developing new technologies and computational methods that serve our wide research interests, which range from genomic sequence to biological mechanisms, molecular structure, and, eventually, clinical translation.
Thinking outside the box, keeping our minds open to new approaches and solutions, embracing diversity, and collaborating with scientists across a wide spectrum of expertise, countries and academic or industry affiliations.

Research Impact

The Krogan lab’s quantitative and unbiased approaches to molecular interaction mapping are disease-agnostic, and hold great promise for the discovery of new therapeutic targets through the identification of biological processes and mechanisms underlying disease. For instance, creating a large-scale protein-interaction map of SARS-CoV-2 with human cells led to the discovery of over 300 potential host-directed drug targets. Several existing drugs inhibited the virus in lab experiments, leading to clinical trials that test the repurposing of these drugs against COVID-19. In collaboration with other Gladstone labs, Krogan and his team are currently also tackling cardiac diseases, tauopathies, psychiatric and neurodevelopmental diseases, and are developing new proteomics and functional genomics technologies.

 

Professional Titles

Senior Investigator, Gladstone Institutes

Professor, Cellular and Molecular Pharmacology, UC San Francisco

Director, Quantitative Bioscience Institute (QBI)

Faculty, Cancer Genetics, Helen Diller Family Comprehensive Cancer Center

Adjunct Faculty, Buck Institute for Research on Aging

Joint Faculty, Sanford Burnham Prebys Medical Discovery Institute

Director, QB3@UCSF, California Institute for Quantitative Biosciences

Director, Thermo Fisher Scientific Proteomics Facility for Disease Target Discovery

Bio

Nevan Krogan is an expert in systems biology and is known for developing and using unbiased, quantitative approaches to study a variety of diseases with the goal of developing new therapeutics. He is a senior investigator at the Gladstone Institutes, a UC San Francisco (UCSF) professor, and Director of the intensely interdisciplinary Quantitative Biosciences Institute (QBI). He has authored over 350 papers and given over 400 seminars worldwide. He is a Searle Scholar, a Keck Distinguished Scholar, a recipient of the Roddenberry Prize for Biomedical Research, and was elected to EMBO (European Molecular Biology Organization) membership. He routinely organizes international conferences in Europe, Asia and the USA.

Krogan serves as the director and co-director of several NIH-funded Center grants, including the HIV Accessory and Regulatory Complexes Center, the Cancer Cell Map Initiative, the Host Pathogen Map Initiative, the Psychiatric Cell Map Initiative and the QBI Coronavirus Research Group Pandemic Response Program.

Originally from Canada, Krogan earned bachelor’s and master’s degrees in chemistry and biochemistry from the University of Regina, Canada. He earned a PhD in medical genetics from the University of Toronto and was a Sandler Fellow at UCSF before becoming faculty.

How did you get your start in science?

"As an undergraduate student, I watched “Mary Shelley’s Frankenstein” and was attracted to the freedom Dr. Frankenstein had in the laboratory to conduct his own research."

Nevan Krogan, PhD

Honors and Awards

2022 Elected to the European Molecular Biology Organization (EMBO)

2021 France Legion of Honor, decreed by the President of the French Republic

2020 Excellence in Research Award from the Laboratory of Genomics Research (LGR)

2020 Clarivate Web of Science, Highly Cited Researchers 2020 - ranked in top 1% of citations for field and year

2017 The Roddenberry Innovation Award, Roddenberry Foundation

2015-2016 Blavatnik National Award Finalist, Blavatnik Foundation

2014 Top 40 Under 40, Cell

2012 Alumni Crowning Achievement Award, University of Regina

2009 Searle Scholar, Searle Foundation

2009-2014 Keck Distinguished Young Scholar, W.M. Keck Foundation

2005 L.W. Macpherson Microbiology Award

2004 Hannah Farkas-Himsley and Alexander Memorial Award

2001 Canadian Institute of Health Research (CIHR) Doctoral Fellowship

1999 PGS-B Award, Natural Sciences and Engineering Research Council

1997 Society of Chemical Industry Merit Award

1995 Canadian Cancer Society Studentship

Publications

More Publications

Contact

Nevan Krogan
Email
415.734.2583


Lab Members

Peggy Ackerberg, MA
Affiliate
Rithika Adavikolanu
Visiting Researcher
Ronald Babu, PhD
Affiliate
Jyoti Batra, PhD
Staff Research Scientist II
Jeffrey Beck, MBA
Affiliate
Mehdi Bouhaddou, PhD
Visiting Postdoc
Merve Cakir, PhD
Visiting Postdoc
Zeynep Cakir Wheeler, PhD
Postdoctoral Scholar
Manon Eckhardt, PhD
Staff Research Scientist II
Jacqueline Fabius
Affiliate
Antoine Forget, PhD
Visiting Scientist
Andrea Fossati, PhD
Visiting Postdoc
Helene Foussard, PhD
Visiting Scientist
Kelsey Haas
Visiting Postdoc
Paige Haas
Graduate Student
Reuben Hogan
Graduate Student
Ruth Huettenhain, PhD
Visiting Scientist
Gwendolyn Jang, PhD
Affiliate
Lian Jeong Engle
Student Intern
Robyn Kaake, PhD
Visiting Scientist
Prachi Khare
Affiliate
Minkyu Kim, PhD
Visiting Scientist
Einar Krogsaeter, PhD
Postdoctoral Scholar
Reanna Lao
Rotation Student
Qiongyu Li, PhD
Visiting Postdoc
Michael McGregor, MS
Research Scientist
Justin McKetney
Affiliate
Hevatib Mehmood
Affiliate
Maya Modak
Visiting Researcher
Jack Moen
Visiting Postdoc
Monita Muralidharan, PhD
Visiting Scientist
Snow Naing
Graduate Student
Virginia Nguyen
Affiliate
Kirsten Obernier, PhD
Visiting Scientist
Adrian Pelin
Visiting Scientist
Vincenzo Pierotti
Affiliate
Benjamin Polacco, PhD
Affiliate
Ernst Pulido
Research Associate II
Alicia Richards, PhD
Visiting Scientist
Ajda Rojc
Research Associate III
Delini Samarasinghe
Visiting Researcher
Margaret Soucheray
Visiting Researcher
Erica Stevenson, MS
Research Technologist III
Danielle Swaney, PhD
Visiting Scientist
Alice Taubes
Visiting Scientist
Manisha Ummadi
Visiting Researcher
Rasika Vartak
Affiliate
Matt Ward
Rotation Student
Xiaofang Zhong, PhD
Visiting Postdoc
Yuan Zhou, MS
Bioinformatician I
Lorena Zuliani Alvarez, PhD
Affiliate