Nevan Krogan uses large-scale genetics and biochemistry to define the interactions among genes and proteins that govern cell functions in health and disease. Combining bench work with computer science, his lab identifies molecular networks acting inside cells and shows how these networks respond to disease-causing mutations or infection by pathogens. Thanks to their ability to survey a cell’s complete set of genes and proteins, Krogan and his team generate novel mechanistic insights into cell biology, as well as potential targets for novel therapies. Krogan’s lab is applying this unbiased approach to a number of conditions, including infectious diseases, cancer, and heart disease.

Disease Areas

Cancer
Heart Disease
Infectious Diseases
Pain
Psychiatric Disorders
Tauopathies

Areas of Expertise

Computational Analysis
Functional Genomics
Proteomics
Gladstone_KroganEckhardt2018.jpg

Lab Focus

Understanding how biological networks change in response to a variety of conditions, including stress, genetic mutations, drug treatment, or infection by pathogens.
Developing new technologies and computational methods that serve our wide research interests, which range from genomic sequence, to biological mechanisms, to molecular structure, and, eventually to clinical translation.
Thinking outside the box, keeping our minds open to new approaches and solutions, embracing diversity, and collaborating with scientists across a wide spectrum of expertise, countries, and academic or industry affiliations.

Research Impact

The Krogan lab’s quantitative and unbiased approaches to molecular interaction mapping are disease-agnostic, and hold great promise for the discovery of new therapeutic targets through the identification of biological processes and mechanisms underlying disease. For instance, creating a large-scale protein-interaction map of Ebola virus with human cells led to the discovery of a small molecule that severely decreases virus replication in lab settings, and identified almost 200 additional potential host-directed drug targets. In collaboration with other Gladstone labs, Krogan and his team are currently also tackling cardiac diseases, tauopathies, and psychiatric diseases, and are developing new proteomics and functional genomics technologies.

 

Professional Titles

Senior Investigator, Gladstone Institute of Data Science and Biotechnology

Professor, Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research, UC San Francisco

Director, Quantitative Bioscience Institute (QBI)

Faculty, Cancer Genetics, Helen Diller Family Comprehensive Cancer Center

Adjunct Faculty, Buck Institute for Research on Aging

Joint Faculty, Sanford Burnham Prebys Medical Discovery Institute

Director, QB3@UCSF, California Institute for Quantitative Biosciences

Director, Thermo Fisher Scientific Proteomics Facility for Disease Target Discovery

Bio

Nevan Krogan is an expert in the field of systems biology and is known for extracting biological mechanism and insight from large-scale biological datasets. He has received numerous awards including being named a Searle Scholar and a Keck Distinguished Young Scholar, as well as being awarded the Roddenberry Prize in 2017. Krogan was also recently named one of the top 40 under 40 by the journal Cell. He is routinely an organizer of international conferences including meetings in Europe, Asia, and the USA. Krogan is also the director and co-director of several NIH-funded Center Grants, including the HARC Center (HIV Accessory and Regulatory Complexes), the Cancer Cell Map Initiative, the Host Pathogen Map Initiative, and the Psychiatric Cell Map Initiative.

Originally from Canada, Krogan earned a bachelor’s degree in chemistry and a master’s degree in biochemistry from the University of Regina, in the Canadian province of Saskatchewan. He earned a PhD in medical genetics from the University of Toronto and was an independent Sandler Fellow at UC San Francisco (UCSF) before being appointed UCSF faculty in 2007.

Why Are You Dedicated to Discovery

“Throughout my career, I have built tools to catalog the cross talk between proteins and genes in all types of cells; I am driven by desire to share this technology with others and apply it to a broad range of diseases.”

Nevan , PhD

Honors and Awards

2017 The Roddenberry Innovation Award, Roddenberry Foundation

2015-2016 Blavatnik National Award Finalist, Blavatnik Foundation

2014 Top 40 Under 40, Cell

2012 Alumni Crowning Achievement Award, University of Regina

2009 Searle Scholar, Searle Foundation

2009-2014 Keck Distinguished Young Scholar, W.M. Keck Foundation

2005 L.W. Macpherson Microbiology Award

2004 Hannah Farkas-Himsley and Alexander Memorial Award

2001 Canadian Institute of Health Research (CIHR) Doctoral Fellowship

1999 PGS-B Award, Natural Sciences and Engineering Research Council

1997 Society of Chemical Industry Merit Award

1995 Canadian Cancer Society Studentship

Publications

More Publications

Contact

Nevan

415.734.2583

Peggy
Visiting Staff
415.476.6109


Lab Members

Peggy , MA
Visiting Staff
Beatrice
Graduate Student
Jyoti , PhD
Scientist
Jeffrey , MBA
Visiting Staff
Mehdi , PhD
Visiting Postdoc
Merve , PhD
Visiting Postdoc
Zeynep , PhD
Postdoctoral Scholar
Gary
Visiting Researcher
Kuei-Ho , MS
Research Technologist II
Manon , PhD
Staff Research Scientist II
Jacqueline
Visiting Researcher
Helene
Visiting Scientist
John , MD, PhD
Visiting Scientist
David , PhD
Staff Research Scientist I
Jeffrey
Visiting Researcher
Kelsey
Graduate Student
Paige
Graduate Student
Joseph
Graduate Student
Ruth , PhD
Visiting Postdoc
Judd , PhD
Visiting Scientist
Yeonjoo
Visiting Researcher
Robyn , PhD
Visiting Scientist
Minkyu , PhD
Visiting Scientist
Dmitry , PhD
Visiting Postdoc
Qiongyu , PhD
Visiting Postdoc
Michael , MS
Senior Research Associate
Maya
Visiting Researcher
Monita , PhD
Visiting Postdoc
Zun Zar Chi
Graduate Student
Virginia
Visiting Staff
Kirsten , PhD
Visiting Scientist
Trupti
Visiting Researcher
Vincenzo
Visiting Staff
Benjamin , PhD
Visiting Scientist
Ernst
Research Assistant
Ujjwal , PhD
Visiting Scientist
Alicia , PhD
Visiting Scientist
Ajda
Visiting Researcher
Maliheh , PhD
Visiting Postdoc
Margaret
Visiting Staff
Erica , MS
Research Technologist II
Danielle , PhD
Visiting Scientist
Rigney , PhD
Visiting Postdoc
Beril , PhD
Visiting Postdoc